2. Gene
  3. HOXB6 - homeobox B6 Gene

HOXB6 - homeobox B6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：同源框 B6

种属: Homo sapiens

同用名: HOX2; HU-2; HOX2B; Hox-2.2

基因 ID: 3216 | 基因类型: protein coding

关于 HOXB6

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,595,751-48,604,986 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 42 paralogues. Biased expression in kidney (RPKM 11.8), colon (RPKM 5.2) and 9 other tissues.

功能概要

该基因是 Antp 同源框家族的成员，编码具有同源框 DNA 结合域的蛋白质。它包含在位于 17 号染色体上的同源框 B 基因簇中。编码的蛋白质作为一种序列特异性转录因子起作用，参与发育，包括肺和皮肤的发育，并且已定位于细胞核和细胞质。该基因表达的改变或其蛋白质亚细胞定位的变化与某些急性髓性白血病和结直肠癌病例有关。[RefSeq 提供，2008 年 7 月]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal Cancer. [provided by RefSeq, Jul 2008]

HOXB6 基因产物(2)

mRNA Protein Name
NM_001369397.2 NP_001356326.1 homeobox protein Hox-B6
NM_018952.5 NP_061825.2 homeobox protein Hox-B6
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HOXB6 蛋白结构

Homeobox

Homeobox: Homeobox domain (147 - 203)

  • 0
  • 100
  • 200
  • 224 a.a.
蛋白主名 其他名称

homeobox protein Hox-B6

homeo box 2B

HOXB6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HOXB6 P17509 TEKT5 Homo sapiens Q96M29
Validated Y2H
32296183
种属内
HOXB6 P17509 NEK6 Homo sapiens Q9HC98-4
Validated Y2H
32296183
种属内
HOXB6 P17509 SRPK2 Homo sapiens P78362
Validated Y2H
32296183
种属内
HOXB6 P17509 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Prey Pooling
25416956
种属内
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
种属内
HOXB6 P17509 CLK3 Homo sapiens P49761
Validated Y2H
32296183
种属内
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Array
25416956
种属内
HOXB6 P17509 CLK3 Homo sapiens P49761
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypospadias

Hypospadias Familial

Familial Hypospadias
Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome

Hfgs

Hfg Syndrome

Hfu Syndrome

HFG

Hfu

Hand Foot Uterus Syndrome

Hand Foot Genital Syndrome
Barrett Esophagus

Barrett'S Esophagus

Barrett Esophagus/Esophageal Adenocarcinoma

Barrett Metaplasia

Barrett'S Ulcer Of Esophagus

Ulcerative Esophagitis

Barrett'S Esophagus With Esophagitis

Barrett'S Oesophagus

Barretts Syndrome

Barrett Syndrome

BE

Peptic Ulcer Of Esophagus

Adenocarcinoma Of Esophagus
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06310 HOXB6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HOXB6 RGD RGD:1562142
Bos taurus HOXB6 VGNC VGNC:106770
Macaca mulatta HOXB6 VGNC VGNC:104620
Mus musculus HOXB6 MGD MGI:96187
Canis familiaris HOXB6 VGNC VGNC:41752
Felis catus HOXB6 VGNC VGNC:99081
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