CLK2 - CDC like kinase 2 Gene

中文名称：CDC 样激酶 2

种属: Homo sapiens

关于 CLK2

功能概要

该基因编码一种双特异性蛋白激酶，可磷酸化丝氨酸/苏氨酸和含酪氨酸的底物。这种蛋白质的活性调节剪接体复合物中富含丝氨酸和精氨酸 (SR) 的蛋白质，从而影响选择性转录剪接。该位点与 19 号染色体上的 PAFAH1B3 (血小板活化因子乙酰水解酶 1b，催化亚基 3 (29kDa) ) 基因之间存在染色体易位，导致融合蛋白的产生。请注意，该基因不同于 TELO2 基因 (GeneID:9894) ，后者共享 CLK2 别名，但编码一种参与端粒长度调节的蛋白质。该基因在 7 号染色体上有一个假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 6 月]

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]