2. Gene
  3. SRSF3 - serine and arginine rich splicing factor 3 Gene

SRSF3 - serine and arginine rich splicing factor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富丝氨酸和精氨酸的剪接因子 3

种属: Homo sapiens

同用名: SFRS3; SRp20

基因 ID: 6428 | 基因类型: protein coding

关于 SRSF3

Cytogenetic location: 6p21.31-p21.2 Genomic coordinates (GRCh38): 6:36,594,362-36,605,600 (from NCBI)

This gene has 8 transcripts (splice variants), 319 orthologues, 8 paralogues and is associated with 50 phenotypes. Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是富含丝氨酸/精氨酸 (SR) 的 pre-mRNA 剪接因子家族的成员，它构成了剪接体的一部分。这些因子中的每一个都包含一个用于结合 RNA 的 RNA 识别基序 (RRM) 和一个用于结合其他蛋白质的 RS 结构域。 RS 结构域富含丝氨酸和精氨酸残基，可促进不同 SR 剪接因子之间的相互作用。除了对 mRNA 剪接至关重要外，SR 蛋白还显示参与 mRNA 从细胞核输出和翻译。已发现该基因的两种转录变体，一种是蛋白质编码的，另一种是非编码的。[RefSeq 提供，2010 年 9 月]

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

SRSF3 基因产物(1)

mRNA Protein Name
NM_003017.5 NP_003008.1 serine/arginine-rich splicing factor 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
26876937 GOA
NOT enables pre-mRNA binding IDA
IDA: 通过直接分析推断
32440474 GOA
enables primary miRNA binding IMP
IMP: 通过突变表型推断
33664453 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14559993 GOA
enables protein-RNA sequence-specific adaptor activity IDA
IDA: 通过直接分析推断
32440474 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA export from nucleus IDA
IDA: 通过直接分析推断
28984244 GOA
involved in primary miRNA processing IMP
IMP: 通过突变表型推断
33664453 GOA
involved in regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
26876937 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nuclear speck IDA
IDA: 通过直接分析推断
26876937 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRSF3 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 77)

  • 0
  • 100
  • 164 a.a.
蛋白主名 其他名称

serine/arginine-rich splicing factor 3

epididymis secretory sperm binding protein

SRSF3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SRSF3 P84103 PCDHB14 Homo sapiens Q9Y5E9
Validated Y2H
32296183
Intra SRSF3 P84103 SRSF8 Homo sapiens Q9BRL6-2
Validated Y2H
32296183
Intra SRSF3 P84103 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra SRSF3 P84103 RBM3 Homo sapiens P98179
Validated Y2H
32296183
Intra SRSF3 P84103 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
Intra SRSF3 P84103 NXF1 Homo sapiens Q9UBU9
Pull Down
17036044
Intra SRSF3 P84103 CIRBP Homo sapiens Q14011
Validated Y2H
32296183
Intra SRSF3 P84103 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra SRSF3 P84103 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
Intra SRSF3 P84103 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
Intra SRSF3 P84103 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra SRSF3 P84103 CNNM3 Homo sapiens Q8NE01
Validated Y2H
32296183
Intra SRSF3 P84103 CLK3 Homo sapiens P49761
Validated Y2H
32296183
Intra SRSF3 P84103 CLK3 Homo sapiens P49761
Y2H Array
32296183
Intra SRSF3 P84103 CLK3 Homo sapiens P49761
Y2H Prey Pooling
32296183
Intra SRSF3 P84103 CLK2 Homo sapiens P49760
Anti Tag CoIP
33961781
Intra SRSF3 P84103 PCBP2 Homo sapiens Q15366
Pull Down
17183366
Cross SRSF3 P84103 Srek1 Rattus norvegicus Q9JKL7
Anti Tag CoIP
14559993
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ocular Hypertension

Hypertension, Ocular

Intraocular Pressure Increase

Oh - [Ocular Hypertension]

Oht - [Ocular Hypertension]
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Intellectual Developmental Disorder, Autosomal Dominant 4

MRD4

Autosomal Dominant Non-Syndromic Intellectual Disability 4

Mental Retardation, Autosomal Dominant 4

Autosomal Dominant Intellectual Developmental Disorder 4
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-148660 SFI003 Inducer 99.75% 否
HY-RS13794 SRSF3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SRSF3 VGNC VGNC:77820
Rattus norvegicus SRSF3 RGD RGD:1309233
Canis familiaris SRSF3 VGNC VGNC:46819
Bos taurus SRSF3 VGNC VGNC:35301
Mus musculus SRSF3 MGD MGI:98285
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