PCBP2 - poly(rC) binding protein 2 Gene

中文名称：聚 (rC) 结合蛋白 2

种属: Homo sapiens

同用名: HNRPE2; HNRNPE2; hnRNP-E2

关于 PCBP2

功能概要

该基因编码的蛋白质似乎是多功能的。与 PCBP-1 和 hnRNPK 一起，它是主要的细胞聚 (rC) 结合蛋白之一。编码的蛋白质包含三个可能参与 RNA 结合的 K 同源 (KH) 结构域。与 PCBP-1 一起，该蛋白还通过与 IRES 的茎环 IV 的序列特异性相互作用作为脊髓灰质炎病毒 RNA 的翻译共激活因子，通过与其 5'-末端三叶草结构结合促进脊髓灰质炎病毒 RNA 复制。它还涉及 15-脂氧合酶 mRNA、人乳头瘤病毒 16 型 L2 mRNA 和甲型肝炎病毒 RNA 的翻译控制。还建议编码的蛋白质在序列特异性 α-珠蛋白 mRNP 复合物的形成中发挥作用，该复合物与 α-珠蛋白 mRNA 稳定性相关。这种多外显子结构 mRNA 被认为是逆转录生成 PCBP-1，一种功能类似于 PCBP2 的无内含子基因。该基因和 PCBP-1 具有旁系同源基因 (PCBP3 和 PCBP4) ，这些基因被认为是整个基因复制事件的结果。该基因还有两个加工过的假基因 (PCBP2P1 和 PCBP2P2) 。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2018 年 1 月]

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. This gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2018]