SNRPA - small nuclear ribonucleoprotein polypeptide A Gene

中文名称：小核核糖核蛋白多肽 A

种属: Homo sapiens

同用名: U1A; Mud1; U1-A

基因 ID: 6626 | 基因类型: protein coding

关于 SNRPA

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,751,203-40,765,389 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 22.2), lymph node (RPKM 20.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质与 U1 小核糖核蛋白的茎环 II 相关联，后者结合前体 mRNA 的 5' 剪接位点并且是剪接所必需的。编码的蛋白质通过二聚化对其自身前体 mRNA 的聚腺苷酸化抑制来自动调节自身，并且与剪接和聚腺苷酸化的偶联有关。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

SNRPA 基因产物(1)

mRNA	Protein	Name
NM_004596.5	NP_004587.1	U1 small nuclear ribonucleoprotein A

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	EXP EXP: 通过实验结果推断	8609632	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	19561594	GOA
enables U1 snRNA binding	IDA IDA: 通过直接分析推断	2147232	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9848648	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of U1 snRNP	IDA IDA: 通过直接分析推断	21113136	GOA
part of U1 snRNP	IPI IPI: 通过物理相互作用推断	33677607	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: 通过物理相互作用推断	30975767	GOA
part of spliceosomal complex	IDA IDA: 通过直接分析推断	9731529	GOA
part of spliceosomal complex	IPI IPI: 通过物理相互作用推断	33677607	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNRPA 蛋白结构

RRM_1

0
100
200
282 a.a.

蛋白主名

其他名称

U1 small nuclear ribonucleoprotein A

U1 small nuclear RNP-specific A

SNRPA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SNRPA	P09012	ENOX2	Homo sapiens	Q16206-2	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	ENOX2	Homo sapiens	Q16206-2	Y2H Array	25416956
种属内	SNRPA	P09012	NDUFAF3	Homo sapiens	Q9BU61-2	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	NDUFAF3	Homo sapiens	Q9BU61-2	Y2H Array	25416956
种属内	SNRPA	P09012	METTL13	Homo sapiens	Q8N6R0	Y2H Array	25416956
种属内	SNRPA	P09012	TIAL1	Homo sapiens	Q01085-2	Validated Y2H	32296183
种属内	SNRPA	P09012	U2AF2	Homo sapiens	P26368-2	Validated Y2H	32296183
种属内	SNRPA	P09012	U2AF2	Homo sapiens	P26368-2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	U2AF2	Homo sapiens	P26368-2	Y2H Array	32296183
种属内	SNRPA	P09012	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
种属内	SNRPA	P09012	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
种属内	SNRPA	P09012	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	PCBP3	Homo sapiens	P57721-2	Validated Y2H	32296183
种属内	SNRPA	P09012	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
种属内	SNRPA	P09012	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
种属内	SNRPA	P09012	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBPMS2	Homo sapiens	Q6ZRY4	Validated Y2H	32296183
种属内	SNRPA	P09012	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Array	32296183
种属内	SNRPA	P09012	RBPMS2	Homo sapiens	Q6ZRY4	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Validated Y2H	32296183
种属内	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	30886144
种属内	SNRPA	P09012	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
种属内	SNRPA	P09012	FUBP1	Homo sapiens	Q96AE4-2	Validated Y2H	32296183
种属内	SNRPA	P09012	FUBP1	Homo sapiens	Q96AE4-2	Y2H Array	32296183
种属内	SNRPA	P09012	FUBP1	Homo sapiens	Q96AE4-2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	PTBP2	Homo sapiens	Q9UKA9-2	Validated Y2H	32296183
种属内	SNRPA	P09012	MBNL2	Homo sapiens	Q5VZF2-2	Validated Y2H	32296183
种属内	SNRPA	P09012	MBNL2	Homo sapiens	Q5VZF2-2	Y2H Array	32296183
种属内	SNRPA	P09012	MBNL2	Homo sapiens	Q5VZF2-2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	TIA1	Homo sapiens	P31483	Anti Bait CoIP	12486009
种属内	SNRPA	P09012	TIA1	Homo sapiens	P31483	Pull Down	12486009
种属内	SNRPA	P09012	NDUFAF3	Homo sapiens	Q9BU61	Validated Y2H	32296183
种属内	SNRPA	P09012	DAZAP1	Homo sapiens	Q96EP5	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	DAZAP1	Homo sapiens	Q96EP5	Validated Y2H	32296183
种属内	SNRPA	P09012	DAZAP1	Homo sapiens	Q96EP5	Y2H Array	32296183
种属内	SNRPA	P09012	MRPL15	Homo sapiens	Q9P015	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	MRPL15	Homo sapiens	Q9P015	Validated Y2H	32296183
种属内	SNRPA	P09012	MRPL15	Homo sapiens	Q9P015	Y2H Array	32296183
种属内	SNRPA	P09012	LHX4	Homo sapiens	Q969G2	Validated Y2H	32296183
种属内	SNRPA	P09012	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
种属内	SNRPA	P09012	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBM3	Homo sapiens	P98179	Validated Y2H	25416956
种属内	SNRPA	P09012	RBM3	Homo sapiens	P98179	Validated Y2H	32296183
种属内	SNRPA	P09012	RBM3	Homo sapiens	P98179	Y2H Array	25416956
种属内	SNRPA	P09012	RBM3	Homo sapiens	P98179	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	RBM3	Homo sapiens	P98179	Y2H Array	29892012
种属内	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
种属内	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
种属内	SNRPA	P09012	RASAL3	Homo sapiens	Q86YV0	Validated Y2H	32296183
种属内	SNRPA	P09012	RASAL3	Homo sapiens	Q86YV0	Y2H Array	32296183
种属内	SNRPA	P09012	RASAL3	Homo sapiens	Q86YV0	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	DDX39B	Homo sapiens	Q13838	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	DDX39B	Homo sapiens	Q13838	Validated Y2H	32296183
种属内	SNRPA	P09012	PTBP1	Homo sapiens	P26599	Y2H Array	31515488
种属内	SNRPA	P09012	PTBP1	Homo sapiens	P26599	Validated Y2H	25416956
种属内	SNRPA	P09012	HNRNPU	Homo sapiens	Q00839	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	HNRNPU	Homo sapiens	Q00839	Crosslink	30021884
种属内	SNRPA	P09012	SFPQ	Homo sapiens	P23246	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	SFPQ	Homo sapiens	P23246	Anti Bait CoIP	9848648
种属内	SNRPA	P09012	CIRBP	Homo sapiens	Q14011	Validated Y2H	25416956
种属内	SNRPA	P09012	CIRBP	Homo sapiens	Q14011	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	CIRBP	Homo sapiens	Q14011	Y2H Array	25416956
种属内	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Y2H	22365833
种属内	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Validated Y2H	32296183
种属内	SNRPA	P09012	SNRPA1	Homo sapiens	P09661	Validated Y2H	25416956
种属内	SNRPA	P09012	GABPB1	Homo sapiens	Q06547	Y2H Array	25416956
种属内	SNRPA	P09012	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
种属内	SNRPA	P09012	RBM4B	Homo sapiens	Q9BQ04	Validated Y2H	32296183
种属内	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
种属内	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
种属内	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
种属内	SNRPA	P09012	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
种属内	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	LENG8	Homo sapiens	Q96PV6	Validated Y2H	25416956
种属内	SNRPA	P09012	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	SNRPA	P09012	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
种属内	SNRPA	P09012	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBM11	Homo sapiens	P57052	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBM11	Homo sapiens	P57052	Validated Y2H	32296183
种属内	SNRPA	P09012	RBM11	Homo sapiens	P57052	Y2H Array	32296183
种属内	SNRPA	P09012	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	SNRPA	P09012	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	SNRPA	P09012	U2AF2	Homo sapiens	P26368	Anti Tag CoIP	22365833
种属内	SNRPA	P09012	U2AF2	Homo sapiens	P26368	Validated Y2H	25416956
种属内	SNRPA	P09012	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	RBMX	Homo sapiens	P38159	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Validated Y2H	32296183
种属内	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H Array	32296183
种属内	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H	22365833
种属内	SNRPA	P09012	TRIR	Homo sapiens	Q9BQ61	Y2H Pooling	16189514
种属内	SNRPA	P09012	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	TNFAIP8L1	Homo sapiens	Q8WVP5	Validated Y2H	32296183
种属内	SNRPA	P09012	TNFAIP8L1	Homo sapiens	Q8WVP5	Y2H Array	32296183
种属内	SNRPA	P09012	CD2BP2	Homo sapiens	O95400	Anti Tag CoIP	35271311
种属内	SNRPA	P09012	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	RBMY1F	Homo sapiens	Q15415	Validated Y2H	32296183
种属内	SNRPA	P09012	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
种属内	SNRPA	P09012	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
种属内	SNRPA	P09012	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	OTX2	Homo sapiens	P32243-2	Validated Y2H	32296183
种属内	SNRPA	P09012	QKI	Homo sapiens	Q96PU8	Validated Y2H	25416956
种属内	SNRPA	P09012	QKI	Homo sapiens	Q96PU8	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	PCBP2	Homo sapiens	Q15366	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	PCBP2	Homo sapiens	Q15366	Y2H Array	25416956
种属内	SNRPA	P09012	PCBP1	Homo sapiens	Q15365	Validated Y2H	25416956
种属内	SNRPA	P09012	PCBP1	Homo sapiens	Q15365	Validated Y2H	32296183
种属内	SNRPA	P09012	PCBP1	Homo sapiens	Q15365	Y2H Prey Pooling	25416956
种属内	SNRPA	P09012	GIGYF1	Homo sapiens	O75420	Y2H Array	32296183
种属内	SNRPA	P09012	GIGYF1	Homo sapiens	O75420	Y2H Prey Pooling	32296183
种属内	SNRPA	P09012	ZCCHC13	Homo sapiens	Q8WW36	Validated Y2H	32296183
种属内	SNRPA	P09012	ZCCHC13	Homo sapiens	Q8WW36	Y2H Array	32296183
种属内	SNRPA	P09012	ZCCHC13	Homo sapiens	Q8WW36	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

SNRPA 抗体

目录号	产品名	应用	反应物种
HY-P82015	U1A Antibody (YA1760)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Mixed Connective Tissue Disease

Sharp Syndrome	Mctd
Connective Tissue Disease Overlap Syndrome	Mixed Collagen Vascular Disease
Mctd - [Mixed Connective Tissue Disease]

Premature Ovarian Failure 18

POF18	Primary Ovarian Insufficiency 18
Ovarian Failure, Premature, Type 18

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Mucopolysaccharidosis, Type Iiia

Mucopolysaccharidosis Type Iiia	MPS3A
Mps Iiia	Sanfilippo Syndrome A
Heparan Sulfate Sulfatase Deficiency	Sulfamidase Deficiency
Heparan Sulfamidase Deficiency	Mpsiiia
Mucopolysaccharidosis Type 3a	Sanfilippo Syndrome Type A
Mucopolysaccharidosis Iii-A	Heparane Sulfamidase Deficiency
Mps 3a	Mucopoly-Saccharidosis Type 3a
Mps Iii-A	Mucopolysaccharidosis 3a
Mucopolysaccharidosis Iii

Mucopolysaccharidosis Iii

Sanfilippo Syndrome	Mucopolysaccharidosis Type Iii
Mucopolysaccharidosis Type 3	Mps Iii
Mpsiii	Sanfilippo Disease
Heparan Sulfate Sulfatase Deficiency	Mucopolysaccharidosis, Mps-Iii
N-Sulphoglucosamine Sulphohydrolase Deficiency	Naglu Deficiency
Sanfilippo'S Syndrome	Mucopoly-Saccharidosis Type 3
Mps3	Sanfilippos Syndrome
Mucopolysaccharidosis Type Iiia	Mps Iii B

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13500	SNRPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13501	SNRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	SNRPA	VGNC	VGNC:97639
Macaca mulatta	SNRPA	VGNC	VGNC:77674
Bos taurus	SNRPA	VGNC	VGNC:35074
Mus musculus	SNRPA	MGD	MGI:1855690
Rattus norvegicus	SNRPA	RGD	RGD:1307416
Others	SNRPA	NCBI

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