2. Gene
  3. SNRPA - small nuclear ribonucleoprotein polypeptide A Gene

SNRPA - small nuclear ribonucleoprotein polypeptide A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：小核核糖核蛋白多肽 A

种属: Homo sapiens

同用名: U1A; Mud1; U1-A

基因 ID: 6626 | 基因类型: protein coding

关于 SNRPA

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,751,203-40,765,389 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 22.2), lymph node (RPKM 20.2) and 25 other tissues.

功能概要

由该基因编码的蛋白质与 U1 小核糖核蛋白的茎环 II 相关联，后者结合前体 mRNA 的 5' 剪接位点并且是剪接所必需的。编码的蛋白质通过二聚化对其自身前体 mRNA 的聚腺苷酸化抑制来自动调节自身，并且与剪接和聚腺苷酸化的偶联有关。[RefSeq 提供，2010 年 10 月]

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

SNRPA 基因产物(1)

mRNA Protein Name
NM_004596.5 NP_004587.1 U1 small nuclear ribonucleoprotein A
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding EXP
EXP: 通过实验结果推断
8609632 GOA
enables RNA binding IDA
IDA: 通过直接分析推断
19561594 GOA
enables U1 snRNA binding IDA
IDA: 通过直接分析推断
2147232 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9848648 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U1 snRNP IDA
IDA: 通过直接分析推断
21113136 GOA
part of U1 snRNP IPI
IPI: 通过物理相互作用推断
33677607 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: 通过物理相互作用推断
30975767 GOA
part of spliceosomal complex IDA
IDA: 通过直接分析推断
9731529 GOA
part of spliceosomal complex IPI
IPI: 通过物理相互作用推断
33677607 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNRPA 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (12 - 82)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (210 - 272)

  • 0
  • 100
  • 200
  • 282 a.a.
蛋白主名 其他名称

U1 small nuclear ribonucleoprotein A

U1 small nuclear RNP-specific A

SNRPA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SNRPA P09012 ENOX2 Homo sapiens Q16206-2
Y2H Prey Pooling
25416956
Intra SNRPA P09012 ENOX2 Homo sapiens Q16206-2
Y2H Array
25416956
Intra SNRPA P09012 NDUFAF3 Homo sapiens Q9BU61-2
Y2H Prey Pooling
25416956
Intra SNRPA P09012 NDUFAF3 Homo sapiens Q9BU61-2
Y2H Array
25416956
Intra SNRPA P09012 METTL13 Homo sapiens Q8N6R0
Y2H Array
25416956
Intra SNRPA P09012 TIAL1 Homo sapiens Q01085-2
Validated Y2H
32296183
Intra SNRPA P09012 U2AF2 Homo sapiens P26368-2
Validated Y2H
32296183
Intra SNRPA P09012 U2AF2 Homo sapiens P26368-2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 U2AF2 Homo sapiens P26368-2
Y2H Array
32296183
Intra SNRPA P09012 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra SNRPA P09012 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra SNRPA P09012 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 PCBP3 Homo sapiens P57721-2
Validated Y2H
32296183
Intra SNRPA P09012 CHTOP Homo sapiens Q9Y3Y2-3
Validated Y2H
32296183
Intra SNRPA P09012 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Array
32296183
Intra SNRPA P09012 CHTOP Homo sapiens Q9Y3Y2-3
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBPMS2 Homo sapiens Q6ZRY4
Validated Y2H
32296183
Intra SNRPA P09012 RBPMS2 Homo sapiens Q6ZRY4
Y2H Array
32296183
Intra SNRPA P09012 RBPMS2 Homo sapiens Q6ZRY4
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Validated Y2H
32296183
Intra SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
30886144
Intra SNRPA P09012 RBMY1A1 Homo sapiens P0DJD3-2
Y2H Array
32296183
Intra SNRPA P09012 FUBP1 Homo sapiens Q96AE4-2
Validated Y2H
32296183
Intra SNRPA P09012 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
Intra SNRPA P09012 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 PTBP2 Homo sapiens Q9UKA9-2
Validated Y2H
32296183
Intra SNRPA P09012 MBNL2 Homo sapiens Q5VZF2-2
Validated Y2H
32296183
Intra SNRPA P09012 MBNL2 Homo sapiens Q5VZF2-2
Y2H Array
32296183
Intra SNRPA P09012 MBNL2 Homo sapiens Q5VZF2-2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 TIA1 Homo sapiens P31483
Anti Bait CoIP
12486009
Intra SNRPA P09012 TIA1 Homo sapiens P31483
Pull Down
12486009
Intra SNRPA P09012 NDUFAF3 Homo sapiens Q9BU61
Validated Y2H
32296183
Intra SNRPA P09012 DAZAP1 Homo sapiens Q96EP5
Y2H Prey Pooling
32296183
Intra SNRPA P09012 DAZAP1 Homo sapiens Q96EP5
Validated Y2H
32296183
Intra SNRPA P09012 DAZAP1 Homo sapiens Q96EP5
Y2H Array
32296183
Intra SNRPA P09012 MRPL15 Homo sapiens Q9P015
Y2H Prey Pooling
32296183
Intra SNRPA P09012 MRPL15 Homo sapiens Q9P015
Validated Y2H
32296183
Intra SNRPA P09012 MRPL15 Homo sapiens Q9P015
Y2H Array
32296183
Intra SNRPA P09012 LHX4 Homo sapiens Q969G2
Validated Y2H
32296183
Intra SNRPA P09012 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra SNRPA P09012 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBM3 Homo sapiens P98179
Validated Y2H
25416956
Intra SNRPA P09012 RBM3 Homo sapiens P98179
Validated Y2H
32296183
Intra SNRPA P09012 RBM3 Homo sapiens P98179
Y2H Array
25416956
Intra SNRPA P09012 RBM3 Homo sapiens P98179
Y2H Prey Pooling
25416956
Intra SNRPA P09012 RBM3 Homo sapiens P98179
Y2H Array
29892012
Intra SNRPA P09012 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
Intra SNRPA P09012 HNRNPK Homo sapiens P61978
Validated Y2H
25416956
Intra SNRPA P09012 HNRNPK Homo sapiens P61978
Anti Tag CoIP
35271311
Intra SNRPA P09012 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra SNRPA P09012 RASAL3 Homo sapiens Q86YV0
Validated Y2H
32296183
Intra SNRPA P09012 RASAL3 Homo sapiens Q86YV0
Y2H Array
32296183
Intra SNRPA P09012 RASAL3 Homo sapiens Q86YV0
Y2H Prey Pooling
32296183
Intra SNRPA P09012 DDX39B Homo sapiens Q13838
Anti Tag CoIP
35271311
Intra SNRPA P09012 DDX39B Homo sapiens Q13838
Validated Y2H
32296183
Intra SNRPA P09012 PTBP1 Homo sapiens P26599
Y2H Array
31515488
Intra SNRPA P09012 PTBP1 Homo sapiens P26599
Validated Y2H
25416956
Intra SNRPA P09012 HNRNPU Homo sapiens Q00839
Anti Tag CoIP
35271311
Intra SNRPA P09012 HNRNPU Homo sapiens Q00839
Crosslink
30021884
Intra SNRPA P09012 SFPQ Homo sapiens P23246
Anti Tag CoIP
35271311
Intra SNRPA P09012 SFPQ Homo sapiens P23246
Anti Bait CoIP
9848648
Intra SNRPA P09012 CIRBP Homo sapiens Q14011
Validated Y2H
25416956
Intra SNRPA P09012 CIRBP Homo sapiens Q14011
Y2H Prey Pooling
25416956
Intra SNRPA P09012 CIRBP Homo sapiens Q14011
Y2H Array
25416956
Intra SNRPA P09012 SNRPA1 Homo sapiens P09661
Y2H
22365833
Intra SNRPA P09012 SNRPA1 Homo sapiens P09661
Anti Tag CoIP
35271311
Intra SNRPA P09012 SNRPA1 Homo sapiens P09661
Validated Y2H
32296183
Intra SNRPA P09012 SNRPA1 Homo sapiens P09661
Validated Y2H
25416956
Intra SNRPA P09012 GABPB1 Homo sapiens Q06547
Y2H Array
25416956
Intra SNRPA P09012 HNRNPK Homo sapiens P61978-2
Validated Y2H
32296183
Intra SNRPA P09012 RBM4B Homo sapiens Q9BQ04
Validated Y2H
32296183
Intra SNRPA P09012 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra SNRPA P09012 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra SNRPA P09012 TRIM27 Homo sapiens P14373
Validated Y2H
32296183
Intra SNRPA P09012 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra SNRPA P09012 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra SNRPA P09012 LENG8 Homo sapiens Q96PV6
Y2H Prey Pooling
25416956
Intra SNRPA P09012 LENG8 Homo sapiens Q96PV6
Anti Tag CoIP
35271311
Intra SNRPA P09012 LENG8 Homo sapiens Q96PV6
Validated Y2H
25416956
Intra SNRPA P09012 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra SNRPA P09012 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra SNRPA P09012 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBM11 Homo sapiens P57052
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBM11 Homo sapiens P57052
Validated Y2H
32296183
Intra SNRPA P09012 RBM11 Homo sapiens P57052
Y2H Array
32296183
Intra SNRPA P09012 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra SNRPA P09012 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra SNRPA P09012 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra SNRPA P09012 U2AF2 Homo sapiens P26368
Anti Tag CoIP
22365833
Intra SNRPA P09012 U2AF2 Homo sapiens P26368
Validated Y2H
25416956
Intra SNRPA P09012 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra SNRPA P09012 RBMX Homo sapiens P38159
Y2H Prey Pooling
25416956
Intra SNRPA P09012 RBMX Homo sapiens P38159
Anti Tag CoIP
35271311
Intra SNRPA P09012 TRIR Homo sapiens Q9BQ61
Validated Y2H
32296183
Intra SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H Prey Pooling
32296183
Intra SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H Array
32296183
Intra SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H
22365833
Intra SNRPA P09012 TRIR Homo sapiens Q9BQ61
Y2H Pooling
16189514
Intra SNRPA P09012 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Prey Pooling
32296183
Intra SNRPA P09012 TNFAIP8L1 Homo sapiens Q8WVP5
Validated Y2H
32296183
Intra SNRPA P09012 TNFAIP8L1 Homo sapiens Q8WVP5
Y2H Array
32296183
Intra SNRPA P09012 CD2BP2 Homo sapiens O95400
Anti Tag CoIP
35271311
Intra SNRPA P09012 RBMY1F Homo sapiens Q15415
Y2H Prey Pooling
32296183
Intra SNRPA P09012 RBMY1F Homo sapiens Q15415
Validated Y2H
32296183
Intra SNRPA P09012 RBMY1F Homo sapiens Q15415
Y2H Array
32296183
Intra SNRPA P09012 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Intra SNRPA P09012 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra SNRPA P09012 OTX2 Homo sapiens P32243-2
Validated Y2H
32296183
Intra SNRPA P09012 QKI Homo sapiens Q96PU8
Validated Y2H
25416956
Intra SNRPA P09012 QKI Homo sapiens Q96PU8
Y2H Prey Pooling
25416956
Intra SNRPA P09012 PCBP2 Homo sapiens Q15366
Y2H Prey Pooling
25416956
Intra SNRPA P09012 PCBP2 Homo sapiens Q15366
Y2H Array
25416956
Intra SNRPA P09012 PCBP1 Homo sapiens Q15365
Validated Y2H
25416956
Intra SNRPA P09012 PCBP1 Homo sapiens Q15365
Validated Y2H
32296183
Intra SNRPA P09012 PCBP1 Homo sapiens Q15365
Y2H Prey Pooling
25416956
Intra SNRPA P09012 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra SNRPA P09012 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Intra SNRPA P09012 ZCCHC13 Homo sapiens Q8WW36
Validated Y2H
32296183
Intra SNRPA P09012 ZCCHC13 Homo sapiens Q8WW36
Y2H Array
32296183
Intra SNRPA P09012 ZCCHC13 Homo sapiens Q8WW36
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mixed Connective Tissue Disease

Sharp Syndrome

Mctd

Connective Tissue Disease Overlap Syndrome

Mixed Collagen Vascular Disease

Mctd - [Mixed Connective Tissue Disease]
Premature Ovarian Failure 18

POF18

Primary Ovarian Insufficiency 18

Ovarian Failure, Premature, Type 18
Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Mucopolysaccharidosis, Type Iiia

Mucopolysaccharidosis Type Iiia

MPS3A

Mps Iiia

Sanfilippo Syndrome A

Heparan Sulfate Sulfatase Deficiency

Sulfamidase Deficiency

Heparan Sulfamidase Deficiency

Mpsiiia

Mucopolysaccharidosis Type 3a

Sanfilippo Syndrome Type A

Mucopolysaccharidosis Iii-A

Heparane Sulfamidase Deficiency

Mps 3a

Mucopoly-Saccharidosis Type 3a

Mps Iii-A

Mucopolysaccharidosis 3a

Mucopolysaccharidosis Iii
Mucopolysaccharidosis Iii

Sanfilippo Syndrome

Mucopolysaccharidosis Type Iii

Mucopolysaccharidosis Type 3

Mps Iii

Mpsiii

Sanfilippo Disease

Heparan Sulfate Sulfatase Deficiency

Mucopolysaccharidosis, Mps-Iii

N-Sulphoglucosamine Sulphohydrolase Deficiency

Naglu Deficiency

Sanfilippo'S Syndrome

Mucopoly-Saccharidosis Type 3

Mps3

Sanfilippos Syndrome

Mucopolysaccharidosis Type Iiia

Mps Iii B
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13500 SNRPA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13501 SNRPA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SNRPA VGNC VGNC:97639
Macaca mulatta SNRPA VGNC VGNC:77674
Bos taurus SNRPA VGNC VGNC:35074
Mus musculus SNRPA MGD MGI:1855690
Rattus norvegicus SNRPA RGD RGD:1307416
Others SNRPA NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z