SNRPA1 - small nuclear ribonucleoprotein polypeptide A' Gene

中文名称：小核核糖核蛋白多肽 A'

种属: Homo sapiens

同用名: Lea1; U2A'

基因 ID: 6627 | 基因类型: protein coding

关于 SNRPA1

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:101,281,510-101,295,248 (from NCBI)

This gene has 15 transcripts (splice variants), 231 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 26.0), testis (RPKM 22.8) and 25 other tissues.

功能概要

启用 RNA 结合活性。通过剪接体和精子发生参与 mRNA 剪接。位于核斑点。部分 U2 型催化步骤 2 剪接体和 U2 型预催化剪接体。与结缔组织病有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in connective tissue disease. [provided by Alliance of Genome Resources, Apr 2022]

SNRPA1 基因产物(1)

mRNA	Protein	Name
NM_003090.4	NP_003081.2	U2 small nuclear ribonucleoprotein A'

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9716128	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	28076346	GOA
involved in spermatogenesis	IGI IGI: 通过遗传相互作用推断	27035939	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of U2-type catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: 通过直接分析推断	32494006	GOA
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28076346	GOA
part of spliceosomal complex	IDA IDA: 通过直接分析推断	9731529	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNRPA1 蛋白结构

LRR_9

0
100
200
255 a.a.

蛋白主名

其他名称

U2 small nuclear ribonucleoprotein A'

U2 small nuclear ribonucleoprotein polypeptide A'

SNRPA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SNRPA1	P09661	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	ZGPAT	Homo sapiens	Q8N5A5-2	Validated Y2H	32296183
Intra	SNRPA1	P09661	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	32296183
Intra	SNRPA1	P09661	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	28514442
Intra	SNRPA1	P09661	SNRPB2	Homo sapiens	P08579	Anti Tag CoIP	22365833
Intra	SNRPA1	P09661	IKZF1	Homo sapiens	Q13422-7	Validated Y2H	32296183
Intra	SNRPA1	P09661	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	SNRPA1	P09661	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	28514442
Intra	SNRPA1	P09661	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SNRPA1	P09661	ISY1	Homo sapiens	Q9ULR0	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	XAB2	Homo sapiens	Q9HCS7	Crosslink	25599396
Intra	SNRPA1	P09661	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	28514442
Intra	SNRPA1	P09661	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	33961781
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	25416956
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	SNRPA1	P09661	SNRPA	Homo sapiens	P09012	Y2H Array	32296183
Intra	SNRPA1	P09661	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SNRPA1	P09661	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SNRPA1	P09661	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Primary Optic Atrophy

Galloway-Mowat Syndrome 1

Galloway Syndrome	Nephrosis-Neuronal Dysmigration Syndrome
Nephrosis-Microcephaly Syndrome	Camos
Scar5	GAMOS1
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Microcephaly, Hiatal Hernia And Nephrotic Syndrome
Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities	Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly
Scar5, Formerly	Spinocerebellar Ataxia Autosomal Recessive 5
Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities	Camos Syndrome
Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome	Galloway-Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 5	Galloway Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 5

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13501	SNRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SNRPA1	RGD	RGD:2320494
Felis catus	SNRPA1	VGNC	VGNC:80840
Canis familiaris	SNRPA1	VGNC	VGNC:46610
Mus musculus	SNRPA1	MGD	MGI:1916231
Macaca mulatta	SNRPA1	VGNC	VGNC:77675
Bos taurus	SNRPA1	VGNC	VGNC:35075

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SNRPA1 - small nuclear ribonucleoprotein polypeptide A' Gene

关于 SNRPA1

功能概要

SNRPA1 基因产物(1)

SNRPA1 蛋白结构

SNRPA1 蛋白互作信息

关联疾病

直系同源

热门区域

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SNRPA1 - small nuclear ribonucleoprotein polypeptide A' Gene

关于 SNRPA1

功能概要

SNRPA1 基因产物(1)

SNRPA1 蛋白结构

SNRPA1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z