2. Gene
  3. XAB2 - XPA binding protein 2 Gene

XAB2 - XPA binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：XPA 结合蛋白 2

种属: Homo sapiens

同用名: HCNP; HCRN; SYF1; NTC90

基因 ID: 56949 | 基因类型: protein coding

关于 XAB2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:7,619,525-7,629,545 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.5), ovary (RPKM 19.8) and 25 other tissues.

功能概要

通过剪接体参与 mRNA 剪接；转录，DNA 模板；和转录偶联的核苷酸切除修复。位于核质中。 U2 型催化步骤 2 剪接体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in mRNA splicing, via spliceosome; transcription, DNA-templated; and transcription-coupled nucleotide-excision repair. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

XAB2 基因产物(1)

mRNA Protein Name
NM_020196.3 NP_064581.2 pre-mRNA-splicing factor SYF1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10944529 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IDA
IDA: 通过直接分析推断
10944529 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
involved in transcription-coupled nucleotide-excision repair IDA
IDA: 通过直接分析推断
10944529 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in nucleus IDA
IDA: 通过直接分析推断
28076346 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XAB2 蛋白结构

TPR_2

TPR_2: Tetratricopeptide repeat (257 - 284)

TPR_2

TPR_2: Tetratricopeptide repeat (434 - 462)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 855 a.a.
蛋白主名 其他名称

pre-mRNA-splicing factor SYF1

SYF1 homolog, RNA splicing factor

XAB2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra XAB2 Q9HCS7 ISY1 Homo sapiens Q9ULR0
Y2H Array
32296183
Intra XAB2 Q9HCS7 ISY1 Homo sapiens Q9ULR0
Y2H
22365833
Intra XAB2 Q9HCS7 ISY1 Homo sapiens Q9ULR0
Y2H Prey Pooling
32296183
Intra XAB2 Q9HCS7 ISY1 Homo sapiens Q9ULR0
Validated Y2H
32296183
Intra XAB2 Q9HCS7 XPA Homo sapiens P23025
Y2H
10944529
Intra XAB2 Q9HCS7 XPA Homo sapiens P23025
Pull Down
10944529
Intra XAB2 Q9HCS7 POLR2A Homo sapiens P24928
CoIP
10944529
Intra XAB2 Q9HCS7 DHX16 Homo sapiens O60231
Y2H
22365833
Intra XAB2 Q9HCS7 PPIE Homo sapiens Q9UNP9
Y2H Prey Pooling
32296183
Intra XAB2 Q9HCS7 PPIE Homo sapiens Q9UNP9
Y2H Prey Pooling
25416956
Intra XAB2 Q9HCS7 PPIE Homo sapiens Q9UNP9
Validated Y2H
32296183
Intra XAB2 Q9HCS7 PPIE Homo sapiens Q9UNP9
Y2H Array
25416956
Intra XAB2 Q9HCS7 PPIE Homo sapiens Q9UNP9
Y2H Array
32296183
Intra XAB2 Q9HCS7 IK Homo sapiens Q13123
Y2H
22365833
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs
Xeroderma Pigmentosum, Complementation Group A

Xeroderma Pigmentosum Group A

Xp1

Xeroderma Pigmentosum, Group A

XPA

Xeroderma Pigmentosum I

Xeroderma Pigmentosum Complementation Group A

Xp Group A

Xp, Group A

Xeroderma Pigmentosum 1

Xeroderma Pigmentosum, Type 1

XP-A
Uv-Sensitive Syndrome

Uvss

Uv Sensitive Syndrome

Ultraviolet Sensitive Syndrome
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
Choroid Plexus Meningioma

Choroid Meningioma

Meningioma Of The Choroid Plexus
De Sanctis-Cacchione Syndrome

Xerodermic Idiocy

Xeroderma Pigmentosum With Neurologic Manifestation

DSC

Xerodermic Idiocy Of De Sanctis And Cacchione
Xeroderma Pigmentosum, Complementation Group G

Xeroderma Pigmentosum, Group G

Xeroderma Pigmentosum Vii

Xp7

XPG

Xeroderma Pigmentosum Group G

Xp Group G

Xp, Group G

Xpgc

Xeroderma Pigmentosum, Group G/Cockayne Syndrome

Xeroderma Pigmentosum, Type 7

Xeroderma Pigmentosum Complementation Group G

XP-G

Xp-G/Cs

Xeroderma Pigmentosum Group G/Cockayne Syndrome
Cockayne Syndrome B

Cockayne Syndrome Type 2

Cockayne Syndrome, Type B

Cockayne Syndrome Type Ii

CSB

Cockayne Syndrome 2

Cockayne Syndrome Type B

Ckn2

Cockayne Syndrome, Type Ii
Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15863 XAB2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris XAB2 VGNC VGNC:48445
Felis catus XAB2 VGNC VGNC:67101
Mus musculus XAB2 MGD MGI:1914689
Bos taurus XAB2 VGNC VGNC:36981
Macaca mulatta XAB2 VGNC VGNC:78943
Rattus norvegicus XAB2 RGD RGD:621217
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