DHX16 - DEAH-box helicase 16 Gene

中文名称：DEAH 盒解旋酶 16

种属: Homo sapiens

同用名: DBP2; PRP8; Prp2; DDX16; NMOAS; PRPF2; PRO2014

关于 DHX16

功能概要

以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码一个 DEAD box 蛋白，它是参与细胞周期进程的裂殖酵母 Prp8 蛋白的功能同系物。该基因被映射到染色体 6p21.3 上的 MHC 区域，该区域与许多恶性、遗传和自身免疫性疾病基因相关联。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2018 年 5 月]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]