2. Gene
  3. SFPQ - splicing factor proline and glutamine rich Gene

SFPQ - splicing factor proline and glutamine rich Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富脯氨酸和谷氨酰胺的剪接因子

种属: Homo sapiens

同用名: PSF; POMP100; PPP1R140

基因 ID: 6421 | 基因类型: protein coding

关于 SFPQ

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,176,380-35,193,145 (from NCBI)

This gene has 11 transcripts (splice variants), 216 orthologues, 7 paralogues and is associated with 60 phenotypes. Ubiquitous expression in bone marrow (RPKM 84.2), skin (RPKM 34.9) and 25 other tissues.

功能概要

启用 DNA 结合活性；组蛋白脱乙酰酶结合活性；和蛋白质同二聚化活性。通过剪接体参与多个过程，包括选择性 mRNA 剪接；正向调节氧化应激诱导的内在凋亡信号通路； RNA 聚合酶 II 对转录的调控。通过同源重组作用于双链断裂修复的上游或内部。位于染色质；核基质；和副啄木鸟。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within double-strand break repair via homologous recombination. Located in chromatin; nuclear matrix; and paraspeckles. [provided by Alliance of Genome Resources, Apr 2022]

SFPQ 基因产物(1)

mRNA Protein Name
NM_005066.3 NP_005057.1 splicing factor, proline- and glutamine-rich
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
25765647 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
16731528 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9848648 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
25765647 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of innate immune response IDA
IDA: 通过直接分析推断
28712728 GOA
involved in alternative mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
19874820 GOA
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
20813759 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16731528 GOA
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15790595 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22783022 GOA
involved in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
15790595 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25765647 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
16731528 GOA
located in nuclear matrix IDA
IDA: 通过直接分析推断
19874820 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
19874820 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15790595 GOA
located in paraspeckles IDA
IDA: 通过直接分析推断
19874820 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SFPQ 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (299 - 363)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (374 - 433)

NOPS

NOPS: NOPS (NUC059) domain (444 - 495)

  • 0
  • 200
  • 400
  • 600
  • 707 a.a.
蛋白主名 其他名称

splicing factor, proline- and glutamine-rich

100 kDa DNA-pairing protein

SFPQ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SFPQ P23246 PTK6 Homo sapiens Q13882
Pull Down
19439179
种属内
SFPQ P23246 PTK6 Homo sapiens Q13882
Anti Bait CoIP
19439179
种属内
SFPQ P23246 PSPC1 Homo sapiens Q8WXF1
Anti Tag CoIP
33961781
种属内
SFPQ P23246 PSPC1 Homo sapiens Q8WXF1
Confocal
16148043
种属内
SFPQ P23246 SIN3A Homo sapiens Q96ST3
Pull Down
11259580
种属内
SFPQ P23246 NONO Homo sapiens Q15233
PLA
25959826
种属内
SFPQ P23246 PTBP1 Homo sapiens P26599
CoIP
10653975
种属内
SFPQ P23246 THRAP3 Homo sapiens Q9Y2W1
Anti Tag CoIP
20932480
种属内
SFPQ P23246 FMR1 Homo sapiens Q06787
Y2H Pooling
21653829
种属内
SFPQ P23246 SNRPA Homo sapiens P09012
Pull Down
9848648
种属内
SFPQ P23246 SNRPA Homo sapiens P09012
Solution Sedimentation
9848648
种属间
SFPQ P23246 EBNA-LP Epstein-Barr virus Q8AZK7
Anti Bait CoIP
18457437
种属间: 跨种属相互作用 种属内: 同种属相互作用

SFPQ 抗体

目录号 产品名 应用 反应物种
HY-P82195 SFPQ Antibody (YA1940) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Renal Cell Carcinoma, Xp11-Associated

RCCX1

Mit Family Translocation Renal Cell Carcinoma

Renal Cell Carcinoma, Papillary, 1

Carcinoma Associated With Mitf/Tfe Translocation

Translocation Renal Cell Carcinoma

Renal Cell Carcinoma Xp11-Associated

Renal Cell Carcinoma Papillary 1

Carcinoma, Renal Cell, Xp11-Associated
Perivascular Epithelioid Cell Tumor

Pecoma

Perivascular Epithelioid Cell Neoplasms

Neoplasm With Perivascular Epithelioid Cell Differentiation
Dyslexia
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Alveolar Soft Part Sarcoma

ASPS

Alveolar Soft-Part Sarcoma

Sarcoma, Alveolar Soft Part

Alveolar Soft Tissue Sarcoma

Sarcoma Alveolar Soft Part

Adult Alveolar Soft-Part Sarcoma

Childhood Alveolar Soft-Part Sarcoma
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Pick Disease Of Brain

Pick Disease

Pick'S Disease

Pick Disease Of The Brain

Lobar Atrophy Of Brain

Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions

Behavioral Variant Of Frontotemporal Dementia

Dementia In Pick'S Disease

Lobar Atrophy Of The Brain

Bvftd

Bv-Ftd

PIDB

Picks Disease
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12770 SFPQ Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SFPQ VGNC VGNC:103706
Felis catus SFPQ VGNC VGNC:107619
Rattus norvegicus SFPQ RGD RGD:727923
Bos taurus SFPQ VGNC VGNC:34518
Mus musculus SFPQ MGD MGI:1918764
Macaca mulatta SFPQ VGNC VGNC:77184
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z