SIN3A - SIN3 transcription regulator family member A Gene

中文名称：SIN3 转录调节因子家族成员 A

种属: Homo sapiens

同用名: WITKOS

基因 ID: 25942 | 基因类型: protein coding

关于 SIN3A

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,369,379-75,455,815 (from NCBI)

This gene has 21 transcripts (splice variants), 274 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 15.9), thyroid (RPKM 12.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种转录调节蛋白。它包含成对的两亲性螺旋 (PAH) 结构域，这对蛋白质-蛋白质相互作用很重要，并可能介导 Mad-Max 复合物的抑制作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]

SIN3A 基因产物(3)

mRNA	Protein	Name
NM_001145357.2	NP_001138829.1	paired amphipathic helix protein Sin3a
NM_001145358.2	NP_001138830.1	paired amphipathic helix protein Sin3a
NM_015477.3	NP_056292.1	paired amphipathic helix protein Sin3a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	22783022	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9651585	GOA
enables transcription corepressor activity	IMP IMP: 通过突变表型推断	22783022	GOA
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	22783022	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of innate immune response	IMP IMP: 通过突变表型推断	22783022	GOA
involved in heterochromatin formation	IMP IMP: 通过突变表型推断	22783022	GOA
involved in negative regulation of protein localization to nucleus	IMP IMP: 通过突变表型推断	22783022	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22783022	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: 通过突变表型推断	22783022	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	22783022	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of Sin3-type complex	IDA IDA: 通过直接分析推断	14966270	GOA
part of histone deacetylase complex	IDA IDA: 通过直接分析推断	9651585	GOA
located in nucleus	IDA IDA: 通过直接分析推断	22783022	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIN3A 蛋白结构

PAH

Sin3_corepress

0
200
400
600
800
1000
1200
1273 a.a.

蛋白主名

其他名称

paired amphipathic helix protein Sin3a

SIN3 homolog A, transcription regulator

SIN3A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SIN3A	Q96ST3	HDAC2	Homo sapiens	Q92769	Anti Bait CoIP	25314079
种属内	SIN3A	Q96ST3	HDAC2	Homo sapiens	Q92769	Pull Down	16254079
种属内	SIN3A	Q96ST3	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
种属内	SIN3A	Q96ST3	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	25314079
种属内	SIN3A	Q96ST3	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	21258344
种属内	SIN3A	Q96ST3	SKI	Homo sapiens	P12755	CoIP	14525983
种属内	SIN3A	Q96ST3	SKI	Homo sapiens	P12755	Pull Down	10049357
种属内	SIN3A	Q96ST3	SFPQ	Homo sapiens	P23246	Anti Bait CoIP	11259580
种属内	SIN3A	Q96ST3	HCFC1	Homo sapiens	P51610	Anti Bait CoIP	12670868
种属内	SIN3A	Q96ST3	HCFC1	Homo sapiens	P51610	Anti Tag CoIP	12670868
种属内	SIN3A	Q96ST3	HCFC1	Homo sapiens	P51610	Y2H	12670868
种属内	SIN3A	Q96ST3	HTT	Homo sapiens	P42858	Pull Down	10823891
种属内	SIN3A	Q96ST3	PA2G4	Homo sapiens	Q9UQ80	Pull Down	16254079

种属间: 跨种属相互作用 种属内: 同种属相互作用

SIN3A 抗体

目录号	产品名	应用	反应物种
HY-P83623	mSin3A Antibody (YA3368)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Witteveen-Kolk Syndrome

WITKOS	Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation
Sin3a-Related Intellectual Disability Syndrome

Chromosome 15q24 Deletion Syndrome

15q24 Microdeletion Syndrome	Del(15)(Q24)
Monosomy 15q24	15q24 Microdeletion
15q24 Deletion	Interstitial Deletion Of Chromosome 15q24

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Gene Duplication Disease

Gene Duplication Syndrome

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Uterine Corpus Endometrial Carcinoma

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Polymicrogyria

Pmg

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P3242A	Mad1 (6-21) TFA		/	否
HY-RS12925	SIN3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SIN3A	VGNC	VGNC:46177
Rattus norvegicus	SIN3A	RGD	RGD:1311598
Felis catus	SIN3A	VGNC	VGNC:65150
Macaca mulatta	SIN3A	VGNC	VGNC:77275
Mus musculus	SIN3A	MGD	MGI:107157
Bos taurus	SIN3A	VGNC	VGNC:34624

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