2. Gene
  3. SKI - SKI proto-oncogene Gene

SKI - SKI proto-oncogene Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SKI 原癌基因

种属: Homo sapiens

同用名: SGS; SKV

基因 ID: 6497 | 基因类型: protein coding

关于 SKI

Cytogenetic location: 1p36.33-p36.32 Genomic coordinates (GRCh38): 1:2,228,319-2,310,213 (from NCBI)

This gene has 5 transcripts (splice variants), 199 orthologues, 3 paralogues and is associated with 67 phenotypes. Ubiquitous expression in lung (RPKM 8.9), fat (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码禽肉瘤病毒 (v-ski) 癌基因的核原癌基因蛋白同系物。它作为 TGF-β 信号传导的阻遏物发挥作用，并可能在神经管发育和肌肉分化中发挥作用。[RefSeq 提供，2009 年 10 月]

This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]

SKI 基因产物(1)

mRNA Protein Name
NM_003036.4 NP_003027.1 ski oncogene
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
12435627 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
17469184 GOA
enables SMAD binding IPI
IPI: 通过物理相互作用推断
15107821 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8514802 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8514802 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
11441023 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12874272 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
17510063 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
12419246 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in myotube differentiation IDA
IDA: 通过直接分析推断
19008232 GOA
involved in negative regulation of BMP signaling pathway IDA
IDA: 通过直接分析推断
14699069 GOA
involved in negative regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
17054724 GOA
involved in negative regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
12874272 GOA
acts upstream of or within negative regulation of Schwann cell proliferation IGI
IGI: 通过遗传相互作用推断
15312649 GOA
involved in negative regulation of activin receptor signaling pathway IDA
IDA: 通过直接分析推断
14699069 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11430826 GOA
involved in negative regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
14699069 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
17469184 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12435627 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
12874272 GOA
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
15312649 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
17054724 GOA
involved in positive regulation of DNA binding IDA
IDA: 通过直接分析推断
15107821 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
11430826 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21600873 GOA
located in nuclear body IDA
IDA: 通过直接分析推断
12874272 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10049357 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23610558 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SKI 蛋白结构

Ski_Sno

Ski_Sno: SKI/SNO/DAC family (81 - 190)

c-SKI_SMAD_bind

c-SKI_SMAD_bind: c-SKI Smad4 binding domain (217 - 312)

  • 0
  • 200
  • 400
  • 600
  • 728 a.a.
蛋白主名 其他名称

ski oncogene

Sloan-Kettering Institute proto-oncogene

SKI 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SKI P12755 SMAD2 Homo sapiens Q15796
Anti Bait CoIP
26977879
种属内
SKI P12755 SMAD2 Homo sapiens Q15796
Density Sedimentation
19032343
种属内
SKI P12755 SMAD2 Homo sapiens Q15796
Anti Tag CoIP
19032343
种属内
SKI P12755 SMAD2 Homo sapiens Q15796
TAP
19032343
种属内
SKI P12755 SMAD2 Homo sapiens Q15796
PLA
22442258
种属内
SKI P12755 SMAD2 Homo sapiens Q15796
Anti Bait CoIP
19032343
种属内
SKI P12755 ARK2C Homo sapiens Q6ZSG1
Anti Tag CoIP
23610558
种属内
SKI P12755 SMAD3 Homo sapiens P84022
PLA
22442258
种属内
SKI P12755 SMAD3 Homo sapiens P84022
Anti Bait CoIP
19032343
种属内
SKI P12755 SMAD3 Homo sapiens P84022
Density Sedimentation
19032343
种属内
SKI P12755 SMAD3 Homo sapiens P84022
CoIP
14525983
种属内
SKI P12755 SMAD3 Homo sapiens P84022
CoIP
12857746
种属内
SKI P12755 SMAD3 Homo sapiens P84022
Anti Tag CoIP
19032343
种属内
SKI P12755 SMAD3 Homo sapiens P84022
TAP
19032343
种属内
SKI P12755 SIN3A Homo sapiens Q96ST3
Anti Bait CoIP
10049357
种属内
SKI P12755 NCOR1 Homo sapiens O75376
Anti Bait CoIP
10049357
种属内
SKI P12755 NCOR1 Homo sapiens O75376
TAP
19032343
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
Anti Bait CoIP
26977879
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
Anti Bait CoIP
19032343
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
Density Sedimentation
19032343
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
CoIP
14525983
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
19032343
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
TAP
19032343
种属内
SKI P12755 SMAD4 Homo sapiens Q13485
Y2H
15231748
种属间
SKI P12755 Ncor1 Mus musculus Q60974
Y2H
10049357
种属间
SKI P12755 Ncor1 Mus musculus Q60974
Anti Tag CoIP
10049357
种属间
SKI P12755 Ncor1 Mus musculus Q60974
Pull Down
10049357
种属间
SKI P12755 Satb2 Mus musculus Q8VI24
Anti Bait CoIP
22334647
种属间
SKI P12755 Fam89b Mus musculus Q9QUI1
Y2H
12646588
种属间
SKI P12755 Fam89b Mus musculus Q9QUI1
Anti Bait CoIP
12646588
种属间
SKI P12755 Fam89b Mus musculus Q9QUI1
Pull Down
12646588
种属间
SKI P12755 Fam89b Mus musculus Q9QUI1
Anti Tag CoIP
12646588
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Shprintzen-Goldberg Craniosynostosis Syndrome

Shprintzen-Goldberg Syndrome

Marfanoid Craniosynostosis Syndrome

SGS

Craniosynostosis With Arachnodactyly And Abdominal Hernias

Marfanoid-Craniosynostosis Syndrome

Marfanoid Disorder With Craniosynostosis, Type I

Marfanoid Disorder With Craniosynostosis Type 1

Shprintzen-Goldberg Marfanoid Syndrome

Marfanoid Disorder With Craniosynostosis Type I
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Liver Angiosarcoma

Angiosarcoma Of Liver

Angiosarcoma Of The Liver

Hemangiosarcoma Of The Liver

Primary Angiosarcoma Of Liver

Kupffer Cell Sarcoma Of Liver

Kupffer Cell Sarcoma Of Unspecified Site
Obstructive Nephropathy

Con

Congenital Obstructive Nephropathy

Nephropathy Obstructive
Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis
Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye
Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment

Ncrna Disease

Non-Syndromic Congenital Retinal Non-Attachment

Pfvs

Phpv

Persistent Fetal Vasculature Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10158 Bosutinib 99.96% 是
HY-10158A Bosutinib hydrate Inhibitor 99.87% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-109082 Cevidoplenib Inhibitor 99.58% Phase 2
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13822 SKI II 99.78% 否
HY-12892 SKI-178 98.91% 否
HY-18366A RU-SKI 43 hydrochloride Inhibitor 99.55% 否
HY-109082A Cevidoplenib dimesylate Inhibitor 98.96% 否
HY-115735 SKI-I 99.14% 否
HY-161440 SIK-IN-1 Inhibitor 98.12% 否
HY-18366 RU-SKI 43 Inhibitor / 否
HY-10158S Bosutinib-d8 ≥99.0% 否
HY-12895 SKI V 98.95% 否
HY-106588 Heptaplatin / 否
HY-117563 CAY10621 Inhibitor / 否
HY-161441 SIK-IN-2 Inhibitor / 否
HY-161442 SIK-IN-3 Inhibitor / 否
HY-162143 SKI-349 Inhibitor 99.58% 否
HY-19325 SKI2852 Inhibitor / 否
HY-N12455 Comosone II / 否
HY-RS12969 SKI Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117982 SKI2496 / 否
HY-W714171 Propoxycarbazone sodium / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SKI MGD MGI:98310
Felis catus SKI VGNC VGNC:80357
Canis familiaris SKI VGNC VGNC:46198
Macaca mulatta SKI VGNC VGNC:77374
Bos taurus SKI VGNC VGNC:34647
Rattus norvegicus SKI RGD RGD:1565591
Macaca fascicularis SKI NCBI NCBI:102144358
Others SKI NCBI
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