2. Protein Tyrosine Kinase/RTK
  3. Src Bcr-Abl
  4. Bosutinib hydrate

Bosutinib hydrate  (Synonyms: SKI-606 hydrate)

目录号: HY-10158A 纯度: 99.87%
COA 产品使用指南

摩尔计算器

Bosutinib (hydrate) 是一种口服Src/Abl酪氨酸激酶抑制剂，IC50分别为1.2 nM和1 nM。

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Bosutinib hydrate Chemical Structure

Bosutinib hydrate Chemical Structure

CAS No. : 918639-08-4

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规格 价格 是否有货 数量
5 mg ￥2812
In-stock
10 mg ￥4500
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

Other Forms of Bosutinib hydrate:

Bosutinib hydrate 相关抗体

Top Publications Citing Use of Products

查看 Src 亚型特异性产品:

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Lck Fyn Blk

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bosutinib (hydrate) is an oral Src/Abl tyrosine kinase inhibito with IC50 of 1.2 nM and 1 nM, respectively[1].

IC50 & Target

IC50: 314 nmol/L (Csk, Src family protein tyrosine kinases); IC50: 2.4 nmol/L(Abl kinase).
体外研究
(In Vitro)

Bosutinib (hydrate) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bosutinib hydrate 相关抗体:

Cell Proliferation Assay[2]

Cell Line: The leukemic Bcr-Abl+ cell lines (KCL22, K562, KU812, and Lama84)
Concentration: 0.1 μmol/L
Incubation Time: 72 h
Result: Inhibited several human CML derived cell lines with IC50 values ranging from 1 to 20 nmol/L.
体内研究
(In Vivo)

Bosutinib (hydrate) (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily) has activity against human KU812 xenografts in nude mice. Bosutinib (hydrate) (150 mg/kg; once daily, 5 days weekly) has activity against syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KU812CM L xenograft model[2]
Dosage: 75 mg/kg twice daily or 150 mg/kg once daily
Administration: Bosutinib (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily)
Result: Had the therapeutic activity and produced a dose- and schedule-dependent weight loss.
Animal Model: Syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts[2]
Dosage: 150 mg/kg
Administration: Bosutinib (150 mg/kg; once daily, 5 days weekly)
Result: Decreased the rate of tumor growth and prolonged event-free survival of mice.
Clinical Trial
分子量

548.46

Formula

C26H31Cl2N5O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (182.33 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 1 mg/mL (1.82 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8233 mL 9.1164 mL 18.2329 mL
5 mM 0.3647 mL 1.8233 mL 3.6466 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Bosutinib hydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.8233 mL 9.1164 mL 18.2329 mL 45.5822 mL
DMSO 5 mM 0.3647 mL 1.8233 mL 3.6466 mL 9.1164 mL
10 mM 0.1823 mL 0.9116 mL 1.8233 mL 4.5582 mL
15 mM 0.1216 mL 0.6078 mL 1.2155 mL 3.0388 mL
20 mM 0.0912 mL 0.4558 mL 0.9116 mL 2.2791 mL
25 mM 0.0729 mL 0.3647 mL 0.7293 mL 1.8233 mL
30 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5194 mL
40 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1396 mL
50 mM 0.0365 mL 0.1823 mL 0.3647 mL 0.9116 mL
60 mM 0.0304 mL 0.1519 mL 0.3039 mL 0.7597 mL
80 mM 0.0228 mL 0.1140 mL 0.2279 mL 0.5698 mL
100 mM 0.0182 mL 0.0912 mL 0.1823 mL 0.4558 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bosutinib918639-08-4SKI-606SKI606SKI 606SrcBcr-AblOralSrc/Abl tyrosine kinase inhibitorcancerInhibitorinhibitorinhibit

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目录号：
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