2. Immunology/Inflammation PI3K/Akt/mTOR
  3. SphK Akt mTOR
  4. SKI-349

SKI-349 是一种鞘氨醇激酶 1/2 (SPHK1/2) 和微管聚合 (MDA) 的双重靶向抑制剂。SKI-349 具有抗癌活性。SKI-349 能抑制肝细胞活力、侵袭和 AKT/mTOR 信号通路。

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SKI-349 Chemical Structure

SKI-349 Chemical Structure

CAS No. : 727686-80-8

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规格 价格 是否有货 数量
5 mg ￥1000
In-stock
10 mg ￥1600
In-stock
25 mg ￥3200
In-stock
50 mg ￥5000
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

SKI-349 相关抗体

Top Publications Citing Use of Products

查看 SphK 亚型特异性产品:

查看所有亚型
SphK1 SphK2

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CCRF-CEM IC50
10 nM
Compound: 5p
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
Antiproliferative activity against human CEM cells after 2 days by coulter counter method
[PMID: 19663386]
FM3A IC50
71 nM
Compound: 5p
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
Antiproliferative activity against mouse FM3A cells after 2 days by coulter counter method
[PMID: 19663386]
HeLa IC50
52 nM
Compound: 5p
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
Antiproliferative activity against human HeLa cells after 2 days by coulter counter method
[PMID: 19663386]
HL-60 IC50
22 nM
Compound: SKI-349
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32736077]
L1210 IC50
38 nM
Compound: 5p
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
Antiproliferative activity against mouse L1210 cells after 2 days by coulter counter method
[PMID: 19663386]
MOLT-4 IC50
37 nM
Compound: 5p
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
Antiproliferative activity against human MOLT4 cells after 2 days by coulter counter method
[PMID: 19663386]
分子量

385.44

Formula

C19H19N3O4S
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (324.30 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5944 mL 12.9722 mL 25.9444 mL
5 mM 0.5189 mL 2.5944 mL 5.1889 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SKI-349 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5944 mL 12.9722 mL 25.9444 mL 64.8609 mL
5 mM 0.5189 mL 2.5944 mL 5.1889 mL 12.9722 mL
10 mM 0.2594 mL 1.2972 mL 2.5944 mL 6.4861 mL
15 mM 0.1730 mL 0.8648 mL 1.7296 mL 4.3241 mL
20 mM 0.1297 mL 0.6486 mL 1.2972 mL 3.2430 mL
25 mM 0.1038 mL 0.5189 mL 1.0378 mL 2.5944 mL
30 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1620 mL
40 mM 0.0649 mL 0.3243 mL 0.6486 mL 1.6215 mL
50 mM 0.0519 mL 0.2594 mL 0.5189 mL 1.2972 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0810 mL
80 mM 0.0324 mL 0.1622 mL 0.3243 mL 0.8108 mL
100 mM 0.0259 mL 0.1297 mL 0.2594 mL 0.6486 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKI-349727686-80-8SKI349SKI 349SphKAktmTORSphingosine kinasePKBProtein kinase BMammalian target of RapamycinHepatocellular carcinoma (HCC)liver cellsanticancerAKT/mTORInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-162143
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