2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 信号通路化合物库系列
  6. PI3K/Akt/mTOR 化合物库
PI3K/Akt/mTOR 化合物库 - PI3K/Akt/mTOR Compound Library

Cat. No.: HY-L015

PI3K/Akt/mTOR 信号通路控制着很多和肿瘤发生发展相关的细胞进程，包括细胞凋亡、转录、翻译、代谢、血管生成和细胞周期进程等。这一信号通路的主要节点都在多数人类肿瘤中被激活。该信号通路激活的机制包括 PI3K 上游的酪氨酸激酶受体被激活，编码 PI3K 催化亚基 p110α 的基因 PIK3CA 突变或扩增，抑癌基因 PTEN 的突变或缺失，Akt1 的突变或扩增等。一旦这条信号通路被激活，信号通过 Akt 激活下游一系列底物，包括参与蛋白合成的 mTOR 靶点。因此，抑制该信号通路是癌症预防和/或治疗的有效途径。最近，一些 mTOR 抑制剂已经被批准用对多种癌症的治疗，还有多种新型的 PI3K/Akt/mTOR 抑制剂处于临床研究中。

MCE 收录了 616 个靶向 PI3K/Akt/mTOR 信号通路的小分子化合物，是抗肿瘤药物开发的有用工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE PI3K/Akt/mTOR 化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，597 个产品以 10 mM 浓度提供，18 个产品以 2 mM 浓度提供，1 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 616 small molecule inhibitors used for PI3K/Akt/mTOR pathway research.

•   Targets such as Akt, AMPK, DNA-PK, PDK-1, mTOR, PI3K, PTEN, etc.

•   A valuable tool for studying PI3K/Akt/mTOR-related survival, proliferation, and apoptosis of cells and related diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by the FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Rich documentation with structure, IC50, and summary.

•   NMR and HPLC validated to ensure high purity.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 616 PI3K/Akt/mTOR pathway related compounds supplied as pre-dissolved Solutions or Solid
Solution: 597 compounds supplied in 10 mM solution, 18 compounds supplied in 2 mM solution, 1 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

PI3K (205)

Akt (143)

mTOR (108)

AMPK (78)

GSK-3 (75)

PI4K (15)

PDK-1 (14)

PTEN (7)

MELK (4)

PIN1 (4)

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  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
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联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    PI3K/Akt/mTOR Compound Library
    目录号：
    HY-L015
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