2. Gene
  3. THRAP3 - thyroid hormone receptor associated protein 3 Gene

THRAP3 - thyroid hormone receptor associated protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：甲状腺激素受体相关蛋白 3

种属: Homo sapiens

同用名: BCLAF2; TRAP150

基因 ID: 9967 | 基因类型: protein coding

关于 THRAP3

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:36,207,637-36,305,357 (from NCBI)

This gene has 4 transcripts (splice variants), 282 orthologues, 2 paralogues and is associated with 70 phenotypes. Ubiquitous expression in lymph node (RPKM 27.3), thyroid (RPKM 26.7) and 25 other tissues.

功能概要

启用磷蛋白结合活性；甲状腺激素受体结合活性；和转录共激活因子活性。参与核转录的 mRNA 分解代谢过程；昼夜节律的正向调节； RNA 代谢过程的调控。在 RNA 聚合酶 II 的转录正调控上游或正调控内起作用。位于核斑点。介体复合体的一部分。与外显子-外显子连接复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphoprotein binding activity; Thyroid Hormone Receptor binding activity; and transcription coactivator activity. Involved in nuclear-transcribed mRNA catabolic process; positive regulation of circadian rhythm; and regulation of RNA metabolic process. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Part of mediator complex. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

THRAP3 基因产物(3)

mRNA Protein Name
NM_001321471.2 NP_001308400.1 thyroid hormone receptor-associated protein 3 isoform 1
NM_001321473.2 NP_001308402.1 thyroid hormone receptor-associated protein 3 isoform 2
NM_005119.4 NP_005110.2 thyroid hormone receptor-associated protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear thyroid hormone receptor binding IDA
IDA: 通过直接分析推断
10198638 GOA
enables phosphoprotein binding IDA
IDA: 通过直接分析推断
20932480 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18596238 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
12037571 GOA
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
10198638 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA stabilization IMP
IMP: 通过突变表型推断
18794151 GOA
involved in nuclear-transcribed mRNA catabolic process IDA
IDA: 通过直接分析推断
20123736 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10198638 GOA
involved in positive regulation of circadian rhythm IMP
IMP: 通过突变表型推断
24043798 GOA
involved in positive regulation of mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
20123736 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12037571 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
20932480 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of exon-exon junction complex IDA
IDA: 通过直接分析推断
20123736 GOA
part of mediator complex IDA
IDA: 通过直接分析推断
10198638 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
24100041 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
24100041 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10235267 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THRAP3 蛋白结构

THRAP3_BCLAF1

THRAP3_BCLAF1: THRAP3/BCLAF1 family (123 - 810)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 955 a.a.
蛋白主名 其他名称

thyroid hormone receptor-associated protein 3

BCLAF1 and THRAP3 family member 2

THRAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra THRAP3 Q9Y2W1 EIF4A3 Homo sapiens P38919
Anti Tag CoIP
20123736
Intra THRAP3 Q9Y2W1 SFPQ Homo sapiens P23246
Anti Bait CoIP
20932480
Intra THRAP3 Q9Y2W1 SFPQ Homo sapiens P23246
Anti Tag CoIP
20932480
Intra THRAP3 Q9Y2W1 NXF1 Homo sapiens Q9UBU9
Anti Tag CoIP
20123736
Intra THRAP3 Q9Y2W1 SNW1 Homo sapiens Q13573
Anti Bait CoIP
18794151
Intra THRAP3 Q9Y2W1 SNW1 Homo sapiens Q13573
Anti Tag CoIP
18794151
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 2

MRD2

Autosomal Dominant Non-Syndromic Intellectual Disability 2

Autosomal Dominant Intellectual Developmental Disorder 2

Mental Retardation, Autosomal Dominant 2
Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14500 THRAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta THRAP3 VGNC VGNC:100158
Canis familiaris THRAP3 VGNC VGNC:47354
Rattus norvegicus THRAP3 RGD RGD:1306129
Felis catus THRAP3 VGNC VGNC:66173
Bos taurus THRAP3 VGNC VGNC:35846
Mus musculus THRAP3 MGD MGI:2442637
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z