EIF4A3 - eukaryotic translation initiation factor 4A3 Gene

中文名称：真核翻译起始因子 4A3

种属: Homo sapiens

同用名: Fal1; RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII; eIF4A-III; eIF-4A-III

基因 ID: 9775 | 基因类型: protein coding

关于 EIF4A3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,134,369-80,147,128 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues, 38 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 66.0), adrenal (RPKM 43.4) and 25 other tissues.

功能概要

该基因编码 DEAD box 蛋白家族的一个成员。以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码的蛋白质是核基质蛋白。其氨基酸序列与翻译起始因子 eIF4AI 和 eIF4AII (DEAD 盒蛋白家族的另外两个成员) 的氨基酸序列高度相似。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two Other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

EIF4A3 基因产物(2)

mRNA	Protein	Name
NM_001411099.1	NP_001398028.1	eukaryotic initiation factor 4A-III isoform 2
NM_014740.4	NP_055555.1	eukaryotic initiation factor 4A-III isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	10523622	GOA
enables RNA helicase activity	IDA IDA: 通过直接分析推断	10523622	GOA
enables mRNA binding	IDA IDA: 通过直接分析推断	22961380	GOA
enables poly(A) binding	IDA IDA: 通过直接分析推断	10523622	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10523622	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in embryonic cranial skeleton morphogenesis	IMP IMP: 通过突变表型推断	24360810	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	29301961	GOA
involved in negative regulation of translation	IDA IDA: 通过直接分析推断	10523622	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: 通过突变表型推断	16209946	GOA
involved in positive regulation of translation	IMP IMP: 通过突变表型推断	18423201	GOA
involved in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: 通过直接分析推断	19478851	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of U2-type catalytic step 1 spliceosome	IDA IDA: 通过直接分析推断	29301961	GOA
part of catalytic step 2 spliceosome	IDA IDA: 通过直接分析推断	11991638	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10523622	GOA
part of exon-exon junction complex	IDA IDA: 通过直接分析推断	16601204	GOA
part of exon-exon junction complex	IPI IPI: 通过物理相互作用推断	16931718	GOA
located in nucleus	IDA IDA: 通过直接分析推断	29301961	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4A3 蛋白结构

DEAD

Helicase_C

0
100
200
300
411 a.a.

蛋白主名

其他名称

eukaryotic initiation factor 4A-III

ATP-dependent RNA helicase DDX48

EIF4A3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EIF4A3	P38919	PAX4	Homo sapiens	Q3KNR5	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	PAX4	Homo sapiens	Q3KNR5	Validated Y2H	32296183
种属内	EIF4A3	P38919	PAX4	Homo sapiens	Q3KNR5	Y2H Array	32296183
种属内	EIF4A3	P38919	CNKSR3	Homo sapiens	Q6P9H4	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	CNKSR3	Homo sapiens	Q6P9H4	Validated Y2H	32296183
种属内	EIF4A3	P38919	CNKSR3	Homo sapiens	Q6P9H4	Y2H Array	32296183
种属内	EIF4A3	P38919	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
种属内	EIF4A3	P38919	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
种属内	EIF4A3	P38919	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
种属内	EIF4A3	P38919	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
种属内	EIF4A3	P38919	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
种属内	EIF4A3	P38919	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
种属内	EIF4A3	P38919	VRTN	Homo sapiens	Q9H8Y1	Validated Y2H	32296183
种属内	EIF4A3	P38919	VRTN	Homo sapiens	Q9H8Y1	Y2H Array	32296183
种属内	EIF4A3	P38919	VRTN	Homo sapiens	Q9H8Y1	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	EIF4A3	P38919	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	EIF4A3	P38919	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	ZXDB	Homo sapiens	P98169	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	ZXDB	Homo sapiens	P98169	Validated Y2H	32296183
种属内	EIF4A3	P38919	ZXDB	Homo sapiens	P98169	Y2H Array	32296183
种属内	EIF4A3	P38919	NOM1	Homo sapiens	Q5C9Z4	Anti Tag CoIP	35271311
种属内	EIF4A3	P38919	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
种属内	EIF4A3	P38919	MEOX1	Homo sapiens	P50221	Validated Y2H	32296183
种属内	EIF4A3	P38919	CASC3	Homo sapiens	O15234	TAP	16170325
种属内	EIF4A3	P38919	CASC3	Homo sapiens	O15234	Pull Down	14973490
种属内	EIF4A3	P38919	CASC3	Homo sapiens	O15234	Anti Tag CoIP	16209946
种属内	EIF4A3	P38919	CASC3	Homo sapiens	O15234	Anti Tag CoIP	16601204
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Crosslink	23084401
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	19478851
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	14730019
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	16601204
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Bait CoIP	23084401
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	GMS	23084401
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	23084401
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	TAP	18066079
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Bait CoIP	19410547
种属内	EIF4A3	P38919	MAGOH	Homo sapiens	P61326	Anti Tag CoIP	16209946
种属内	EIF4A3	P38919	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
种属内	EIF4A3	P38919	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
种属内	EIF4A3	P38919	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	PRMT5	Homo sapiens	O14744	Y2H Array	32296183
种属内	EIF4A3	P38919	PRMT5	Homo sapiens	O14744	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	THRAP3	Homo sapiens	Q9Y2W1	Anti Tag CoIP	23084401
种属内	EIF4A3	P38919	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
种属内	EIF4A3	P38919	DDX56	Homo sapiens	Q9NY93	Y2H Array	32296183
种属内	EIF4A3	P38919	DDX56	Homo sapiens	Q9NY93	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	DDX56	Homo sapiens	Q9NY93	Validated Y2H	32296183
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Bait CoIP	19410547
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Bait CoIP	23084401
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	GMS	23084401
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	CoIP	15361857
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	23084401
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	16601204
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	16209946
种属内	EIF4A3	P38919	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	19478851
种属内	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Pull Down	23236153
种属内	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Anti Tag CoIP	23084401
种属内	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Anti Tag CoIP	23236153
种属内	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	Anti Tag CoIP	22365833
种属内	EIF4A3	P38919	CWC22	Homo sapiens	Q9HCG8	BRET	29997244
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Bait CoIP	23084401
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Crosslink	23084401
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	16209946
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	GMS	23084401
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	23084401
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Bait CoIP	19410547
种属内	EIF4A3	P38919	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	16601204
种属内	EIF4A3	P38919	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
种属内	EIF4A3	P38919	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
种属内	EIF4A3	P38919	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
种属内	EIF4A3	P38919	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
种属内	EIF4A3	P38919	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
种属内	EIF4A3	P38919	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	32296183
种属内	EIF4A3	P38919	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	32296183
种属内	EIF4A3	P38919	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	EIF4A3	P38919	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	EIF4A3	P38919	EHMT2	Homo sapiens	Q96KQ7	Y2H Array	32296183
种属内	EIF4A3	P38919	EHMT2	Homo sapiens	Q96KQ7	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	EHMT2	Homo sapiens	Q96KQ7	Validated Y2H	32296183
种属内	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Validated Y2H	32296183
种属内	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Anti Tag CoIP	35271311
种属内	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Y2H Array	32296183
种属内	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Y2H Pooling	16189514
种属内	EIF4A3	P38919	CCDC174	Homo sapiens	Q6PII3	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	DRG2	Homo sapiens	P55039	Y2H Array	32296183
种属内	EIF4A3	P38919	DRG2	Homo sapiens	P55039	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	DRG2	Homo sapiens	P55039	Validated Y2H	32296183
种属内	EIF4A3	P38919	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	EIF4A3	P38919	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
种属内	EIF4A3	P38919	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	EIF4A3	P38919	PDCD4	Homo sapiens	Q53EL6	Validated Y2H	32296183
种属内	EIF4A3	P38919	PDCD4	Homo sapiens	Q53EL6	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

EIF4A3 抗体

目录号	产品名	应用	反应物种
HY-P82077	eIF4A3 Antibody (YA1822)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Robin Sequence With Cleft Mandible And Limb Anomalies

Richieri Costa Pereira Syndrome	Richieri Costa-Pereira Syndrome
Richieri-Costa-Pereira Syndrome	RCPS
Richieri-Costa And Pereira Form Of Acrofacial Dysostosis	Short Stature, Robin Sequence, Cleft Mandible, Pre/Postaxial Hand Anomalies, And Clubfoot
Short Stature-Pierre Robin Sequence-Cleft Mandible-Hand Anomalies Clubfoot Syndrome	Short Stature-Pierre Robin Syndrome-Cleft Mandible-Hand Anomalies Clubfoot Syndrome
Richieri-Costa And Pereira Syndrome

Mandibulofacial Dysostosis, Guion-Almeida Type

Mandibulofacial Dysostosis With Microcephaly	Mandibulofacial Dysostosis-Microcephaly Syndrome
MFDGA	MFDM
Mfdm Syndrome	Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate
Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate	Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome
Dysostosis, Mandibulofacial, Guion-Almeida Type

Acrofacial Dysostosis 1, Nager Type

Nager Syndrome	Nager Acrofacial Dysostosis
AFD1	Preaxial Acrofacial Dysostosis
Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies	Afd, Nager Type
Nager Acrofacial Dysostosis Syndrome	Nafd
Acrofacial Dysostosis, Nager Type	Afd
Preaxial Manibulofacial Dysostosis	Split Hand Deformity-Mandibulofacial Dysostosis
Preaxial Mandibulofacial Dysostosis	Mandibulofacial Dysostosis With Preaxial Limb Anomalies
Preaxial Acrodysostosis	Afd Nager Type
Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies

Acrofacial Dysostosis

Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome	Oculootofacial Dysplasia
BMKS	Oofd
Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance	Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome
Choanal Atresia Deafness Cardiac Defects Dysmorphism	Oculo-Oto-Facial Dysplasia

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Thrombocytopenia-Absent Radius Syndrome

Tar Syndrome	Radial Aplasia-Thrombocytopenia Syndrome
Absent Radii And Thrombocytopenia	TAR
Chromosome 1q21.1 Deletion Syndrome, 200-Kb	Thrombocytopenia Absent Radius Syndrome
Thrombocytopenia Absent Radii	Chromosome 1q21.1 Deletion Syndrome
Thrombocytopenia With Absent Radii Syndrome	Radial Aplasia-Amegakaryocytic Thrombocytopenia

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101785	eIF4A3-IN-2	Inhibitor	99.70%	否
HY-101513	eIF4A3-IN-1	Inhibitor	99.96%	否
HY-33838	eIF4A3-IN-8	Inhibitor	99.98%	否
HY-43913	(R)-eIF4A3-IN-2		≥95.0%	否
HY-148446	eIF4A3-IN-12	Inhibitor	99.70%	否
HY-148450	eIF4A3-IN-16	Inhibitor	98.37%	否
HY-139872	eIF4A3-IN-4	Inhibitor	/	否
HY-145309	eIF4E-IN-3	Inhibitor	/	否
HY-148443	eIF4A3-IN-9	Inhibitor	99.71%	否
HY-148444	eIF4A3-IN-10	Inhibitor	97.87%	否
HY-148445	eIF4A3-IN-11	Inhibitor	99.24%	否
HY-148447	eIF4A3-IN-13	Inhibitor	99.92%	否
HY-148448	eIF4A3-IN-14	Inhibitor	99.81%	否
HY-148449	eIF4A3-IN-15	Inhibitor	/	否
HY-148451	eIF4A3-IN-17	Inhibitor	99.56%	否
HY-148452	eIF4A3-IN-18	Inhibitor	99.58%	否
HY-145359	eIF4A3-IN-5	Inhibitor	/	否
HY-145360	eIF4A3-IN-6	Inhibitor	/	否
HY-145361	eIF4A3-IN-7	Inhibitor	/	否
HY-RS04272	EIF4A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04276	EIF4E3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04279	EIF4EBP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04283	EIF4G3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	EIF4A3	MGD	MGI:1923731
Macaca mulatta	EIF4A3	VGNC	VGNC:99146
Rattus norvegicus	EIF4A3	RGD	RGD:1591139
Bos taurus	EIF4A3	VGNC	VGNC:28406
Canis familiaris	EIF4A3	VGNC	VGNC:40281
Felis catus	EIF4A3	VGNC	VGNC:61789

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