2. Gene
  3. EIF4A3 - eukaryotic translation initiation factor 4A3 Gene

EIF4A3 - eukaryotic translation initiation factor 4A3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 4A3

种属: Homo sapiens

同用名: Fal1; RCPS; DDX48; MUK34; NUK34; NMP265; eIF4AIII; eIF4A-III; eIF-4A-III

基因 ID: 9775 | 基因类型: protein coding

关于 EIF4A3

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:80,134,369-80,147,128 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues, 38 paralogues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 66.0), adrenal (RPKM 43.4) and 25 other tissues.

功能概要

该基因编码 DEAD box 蛋白家族的一个成员。以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程，例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码的蛋白质是核基质蛋白。其氨基酸序列与翻译起始因子 eIF4AI 和 eIF4AII (DEAD 盒蛋白家族的另外两个成员) 的氨基酸序列高度相似。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008]

EIF4A3 基因产物(2)

mRNA Protein Name
NM_001411099.1 NP_001398028.1 eukaryotic initiation factor 4A-III isoform 2
NM_014740.4 NP_055555.1 eukaryotic initiation factor 4A-III isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10523622 GOA
enables RNA helicase activity IDA
IDA: 通过直接分析推断
10523622 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
22961380 GOA
enables poly(A) binding IDA
IDA: 通过直接分析推断
10523622 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10523622 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in embryonic cranial skeleton morphogenesis IMP
IMP: 通过突变表型推断
24360810 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
29301961 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
10523622 GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
IMP: 通过突变表型推断
16209946 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
18423201 GOA
involved in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: 通过直接分析推断
19478851 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type catalytic step 1 spliceosome IDA
IDA: 通过直接分析推断
29301961 GOA
part of catalytic step 2 spliceosome IDA
IDA: 通过直接分析推断
11991638 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10523622 GOA
part of exon-exon junction complex IDA
IDA: 通过直接分析推断
16601204 GOA
part of exon-exon junction complex IPI
IPI: 通过物理相互作用推断
16931718 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29301961 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4A3 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (63 - 225)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (296 - 372)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
蛋白主名 其他名称

eukaryotic initiation factor 4A-III

ATP-dependent RNA helicase DDX48

EIF4A3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EIF4A3 P38919 PAX4 Homo sapiens Q3KNR5
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 PAX4 Homo sapiens Q3KNR5
Validated Y2H
32296183
Intra EIF4A3 P38919 PAX4 Homo sapiens Q3KNR5
Y2H Array
32296183
Intra EIF4A3 P38919 CNKSR3 Homo sapiens Q6P9H4
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 CNKSR3 Homo sapiens Q6P9H4
Validated Y2H
32296183
Intra EIF4A3 P38919 CNKSR3 Homo sapiens Q6P9H4
Y2H Array
32296183
Intra EIF4A3 P38919 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra EIF4A3 P38919 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra EIF4A3 P38919 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra EIF4A3 P38919 CARD9 Homo sapiens Q9H257-2
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra EIF4A3 P38919 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra EIF4A3 P38919 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra EIF4A3 P38919 VRTN Homo sapiens Q9H8Y1
Validated Y2H
32296183
Intra EIF4A3 P38919 VRTN Homo sapiens Q9H8Y1
Y2H Array
32296183
Intra EIF4A3 P38919 VRTN Homo sapiens Q9H8Y1
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra EIF4A3 P38919 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra EIF4A3 P38919 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 ZXDB Homo sapiens P98169
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 ZXDB Homo sapiens P98169
Validated Y2H
32296183
Intra EIF4A3 P38919 ZXDB Homo sapiens P98169
Y2H Array
32296183
Intra EIF4A3 P38919 NOM1 Homo sapiens Q5C9Z4
Anti Tag CoIP
35271311
Intra EIF4A3 P38919 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra EIF4A3 P38919 MEOX1 Homo sapiens P50221
Validated Y2H
32296183
Intra EIF4A3 P38919 CASC3 Homo sapiens O15234
TAP
16170325
Intra EIF4A3 P38919 CASC3 Homo sapiens O15234
Pull Down
14973490
Intra EIF4A3 P38919 CASC3 Homo sapiens O15234
Anti Tag CoIP
16209946
Intra EIF4A3 P38919 CASC3 Homo sapiens O15234
Anti Tag CoIP
16601204
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Crosslink
23084401
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Tag CoIP
19478851
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Tag CoIP
14730019
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Tag CoIP
16601204
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Bait CoIP
23084401
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
GMS
23084401
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Tag CoIP
23084401
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
TAP
18066079
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Bait CoIP
19410547
Intra EIF4A3 P38919 MAGOH Homo sapiens P61326
Anti Tag CoIP
16209946
Intra EIF4A3 P38919 POLR2G Homo sapiens P62487
Validated Y2H
32296183
Intra EIF4A3 P38919 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra EIF4A3 P38919 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 PRMT5 Homo sapiens O14744
Y2H Array
32296183
Intra EIF4A3 P38919 PRMT5 Homo sapiens O14744
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 THRAP3 Homo sapiens Q9Y2W1
Anti Tag CoIP
23084401
Intra EIF4A3 P38919 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 PSMA1 Homo sapiens P25786
Y2H Array
32296183
Intra EIF4A3 P38919 DDX56 Homo sapiens Q9NY93
Y2H Array
32296183
Intra EIF4A3 P38919 DDX56 Homo sapiens Q9NY93
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 DDX56 Homo sapiens Q9NY93
Validated Y2H
32296183
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
Anti Bait CoIP
19410547
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
Anti Bait CoIP
23084401
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
GMS
23084401
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
CoIP
15361857
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
Anti Tag CoIP
23084401
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
Anti Tag CoIP
16601204
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
Anti Tag CoIP
16209946
Intra EIF4A3 P38919 UPF3B Homo sapiens Q9BZI7
Anti Tag CoIP
19478851
Intra EIF4A3 P38919 CWC22 Homo sapiens Q9HCG8
Pull Down
23236153
Intra EIF4A3 P38919 CWC22 Homo sapiens Q9HCG8
Anti Tag CoIP
23084401
Intra EIF4A3 P38919 CWC22 Homo sapiens Q9HCG8
Anti Tag CoIP
23236153
Intra EIF4A3 P38919 CWC22 Homo sapiens Q9HCG8
Anti Tag CoIP
22365833
Intra EIF4A3 P38919 CWC22 Homo sapiens Q9HCG8
BRET
29997244
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
Anti Bait CoIP
23084401
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
Crosslink
23084401
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
Anti Tag CoIP
16209946
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
GMS
23084401
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
Anti Tag CoIP
23084401
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
Anti Bait CoIP
19410547
Intra EIF4A3 P38919 RBM8A Homo sapiens Q9Y5S9
Anti Tag CoIP
16601204
Intra EIF4A3 P38919 CDCA7L Homo sapiens Q96GN5
Y2H Array
25416956
Intra EIF4A3 P38919 CDCA7L Homo sapiens Q96GN5
Y2H Prey Pooling
25416956
Intra EIF4A3 P38919 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra EIF4A3 P38919 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra EIF4A3 P38919 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra EIF4A3 P38919 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
Intra EIF4A3 P38919 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
Intra EIF4A3 P38919 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra EIF4A3 P38919 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra EIF4A3 P38919 EHMT2 Homo sapiens Q96KQ7
Y2H Array
32296183
Intra EIF4A3 P38919 EHMT2 Homo sapiens Q96KQ7
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 EHMT2 Homo sapiens Q96KQ7
Validated Y2H
32296183
Intra EIF4A3 P38919 CCDC174 Homo sapiens Q6PII3
Validated Y2H
32296183
Intra EIF4A3 P38919 CCDC174 Homo sapiens Q6PII3
Anti Tag CoIP
35271311
Intra EIF4A3 P38919 CCDC174 Homo sapiens Q6PII3
Y2H Array
32296183
Intra EIF4A3 P38919 CCDC174 Homo sapiens Q6PII3
Y2H Pooling
16189514
Intra EIF4A3 P38919 CCDC174 Homo sapiens Q6PII3
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 DRG2 Homo sapiens P55039
Y2H Array
32296183
Intra EIF4A3 P38919 DRG2 Homo sapiens P55039
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 DRG2 Homo sapiens P55039
Validated Y2H
32296183
Intra EIF4A3 P38919 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra EIF4A3 P38919 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra EIF4A3 P38919 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra EIF4A3 P38919 PDCD4 Homo sapiens Q53EL6
Validated Y2H
32296183
Intra EIF4A3 P38919 PDCD4 Homo sapiens Q53EL6
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Robin Sequence With Cleft Mandible And Limb Anomalies

Richieri Costa Pereira Syndrome

Richieri Costa-Pereira Syndrome

Richieri-Costa-Pereira Syndrome

RCPS

Richieri-Costa And Pereira Form Of Acrofacial Dysostosis

Short Stature, Robin Sequence, Cleft Mandible, Pre/Postaxial Hand Anomalies, And Clubfoot

Short Stature-Pierre Robin Sequence-Cleft Mandible-Hand Anomalies Clubfoot Syndrome

Short Stature-Pierre Robin Syndrome-Cleft Mandible-Hand Anomalies Clubfoot Syndrome

Richieri-Costa And Pereira Syndrome
Mandibulofacial Dysostosis, Guion-Almeida Type

Mandibulofacial Dysostosis With Microcephaly

Mandibulofacial Dysostosis-Microcephaly Syndrome

MFDGA

MFDM

Mfdm Syndrome

Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate

Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate

Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome

Dysostosis, Mandibulofacial, Guion-Almeida Type
Acrofacial Dysostosis 1, Nager Type

Nager Syndrome

Nager Acrofacial Dysostosis

AFD1

Preaxial Acrofacial Dysostosis

Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies

Afd, Nager Type

Nager Acrofacial Dysostosis Syndrome

Nafd

Acrofacial Dysostosis, Nager Type

Afd

Preaxial Manibulofacial Dysostosis

Split Hand Deformity-Mandibulofacial Dysostosis

Preaxial Mandibulofacial Dysostosis

Mandibulofacial Dysostosis With Preaxial Limb Anomalies

Preaxial Acrodysostosis

Afd Nager Type

Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies
Acrofacial Dysostosis
Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome

Oculootofacial Dysplasia

BMKS

Oofd

Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance

Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome

Choanal Atresia Deafness Cardiac Defects Dysmorphism

Oculo-Oto-Facial Dysplasia
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder
Thrombocytopenia-Absent Radius Syndrome

Tar Syndrome

Radial Aplasia-Thrombocytopenia Syndrome

Absent Radii And Thrombocytopenia

TAR

Chromosome 1q21.1 Deletion Syndrome, 200-Kb

Thrombocytopenia Absent Radius Syndrome

Thrombocytopenia Absent Radii

Chromosome 1q21.1 Deletion Syndrome

Thrombocytopenia With Absent Radii Syndrome

Radial Aplasia-Amegakaryocytic Thrombocytopenia
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101785 eIF4A3-IN-2 Inhibitor 99.70% 否
HY-101513 eIF4A3-IN-1 Inhibitor 99.96% 否
HY-33838 eIF4A3-IN-8 Inhibitor 99.98% 否
HY-148450 eIF4A3-IN-16 Inhibitor 98.37% 否
HY-43913 (R)-eIF4A3-IN-2 ≥95.0% 否
HY-148446 eIF4A3-IN-12 Inhibitor 99.70% 否
HY-148452 eIF4A3-IN-18 Inhibitor 99.58% 否
HY-148444 eIF4A3-IN-10 Inhibitor 97.87% 否
HY-145309 eIF4E-IN-3 Inhibitor / 否
HY-148443 eIF4A3-IN-9 Inhibitor 99.71% 否
HY-148445 eIF4A3-IN-11 Inhibitor 99.24% 否
HY-148447 eIF4A3-IN-13 Inhibitor 99.92% 否
HY-148448 eIF4A3-IN-14 Inhibitor 99.81% 否
HY-148449 eIF4A3-IN-15 Inhibitor / 否
HY-148451 eIF4A3-IN-17 Inhibitor 99.56% 否
HY-139872 eIF4A3-IN-4 Inhibitor / 否
HY-145359 eIF4A3-IN-5 Inhibitor / 否
HY-145360 eIF4A3-IN-6 Inhibitor / 否
HY-145361 eIF4A3-IN-7 Inhibitor / 否
HY-RS04272 EIF4A3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04276 EIF4E3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04279 EIF4EBP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04283 EIF4G3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus EIF4A3 MGD MGI:1923731
Macaca mulatta EIF4A3 VGNC VGNC:99146
Rattus norvegicus EIF4A3 RGD RGD:1591139
Bos taurus EIF4A3 VGNC VGNC:28406
Canis familiaris EIF4A3 VGNC VGNC:40281
Felis catus EIF4A3 VGNC VGNC:61789
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