CASC3 - CASC3 exon junction complex subunit Gene

中文名称：CASC3 外显子连接复合体亚基

种属: Homo sapiens

同用名: BTZ; MLN51

关于 CASC3

功能概要

该基因的产物是外显子连接复合体 (EJC) 的核心成分，EJC 是一种蛋白质复合体，沉积在外显子-外显子连接处的剪接 mRNA 上，并在无义介导的 mRNA 衰变 (NMD) 中发挥作用。编码的蛋白质结合 RNA 并与其他两个 EJC 核心组件相互作用。它主要位于细胞质中，但穿梭到细胞核中，在那里它定位于核斑点。[RefSeq 提供，2008 年 7 月]

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two Other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]