PRMT5 - protein arginine methyltransferase 5 Gene

中文名称：蛋白质精氨酸甲基转移酶 5

种属: Homo sapiens

同用名: HSL7; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5

关于 PRMT5

功能概要

该基因编码一种属于甲基转移酶家族的酶。在包括组蛋白、转录延伸因子和肿瘤抑制因子 p53 在内的靶蛋白中，编码的蛋白质催化甲基转移到氨基酸精氨酸。该基因在多个细胞过程中发挥作用，包括转录调节和小核糖核蛋白的组装。该基因的假基因已在 4 号染色体上定义。可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2015 年 9 月]

This gene encodes an Enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]