YWHAZ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Gene

中文名称：酪氨酸 3-单加氧酶/色氨酸 5-单加氧酶激活蛋白 zeta

种属: Homo sapiens

同用名: HEL4; YWHAD; KCIP-1; HEL-S-3; POPCHAS; HEL-S-93; 14-3-3-zeta

关于 YWHAZ

功能概要

该基因产物属于 14-3-3 蛋白家族，通过与含磷酸丝氨酸的蛋白结合来介导信号转导。这种高度保守的蛋白质家族存在于植物和哺乳动物中，并且这种蛋白质与小鼠、大鼠和绵羊的直系同源物具有 99% 的相同性。编码的蛋白质与 IRS1 蛋白质相互作用，表明其在调节胰岛素敏感性方面发挥作用。已经为该基因鉴定了几种 5' UTR 不同但编码相同蛋白质的转录物变体。[RefSeq 提供，2008 年 10 月]

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating Insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]