2. Gene
  3. WTAP - WT1 associated protein Gene

WTAP - WT1 associated protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WT1 相关蛋白

种属: Homo sapiens

同用名: Mum2

基因 ID: 9589 | 基因类型: protein coding

关于 WTAP

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,726,693-159,756,319 (from NCBI)

This gene has 8 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in bone marrow (RPKM 44.8), lymph node (RPKM 20.4) and 25 other tissues.

功能概要

Wilms 肿瘤抑制基因 WT1 似乎在某些细胞基因的转录和转录后调节中发挥作用。该基因编码 WT1 相关蛋白，这是一种普遍表达的核蛋白。与 WT1 蛋白一样，该蛋白定位于整个核质以及斑点中，并与剪接因子部分共定位。该基因的可变剪接导致编码三种不同亚型的几种转录变体。[RefSeq 提供，2012 年 7 月]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]

WTAP 基因产物(6)

mRNA Protein Name
NM_001270531.2 NP_001257460.1 pre-mRNA-splicing regulator WTAP isoform 1
NM_001270532.2 NP_001257461.1 pre-mRNA-splicing regulator WTAP isoform 3
NM_001270533.2 NP_001257462.1 pre-mRNA-splicing regulator WTAP isoform 3
NM_004906.5 NP_004897.2 pre-mRNA-splicing regulator WTAP isoform 1
NM_152857.3 NP_690596.1 pre-mRNA-splicing regulator WTAP isoform 2
NM_152858.3 NP_690597.1 pre-mRNA-splicing regulator WTAP isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA processing IMP
IMP: 通过突变表型推断
24316715 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
24407421 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA N6-methyladenosine methyltransferase complex IDA
IDA: 通过直接分析推断
24316715 GOA
part of RNA N6-methyladenosine methyltransferase complex IPI
IPI: 通过物理相互作用推断
29507755 GOA
located in nuclear membrane IDA
IDA: 通过直接分析推断
10942595 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
24100041 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
24100041 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10942595 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pre-mRNA-splicing regulator WTAP

PNAS-132

WTAP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WTAP Q15007 ZNF572 Homo sapiens Q7Z3I7
Validated Y2H
32296183
种属内
WTAP Q15007 SLIRP Homo sapiens Q9GZT3
Anti Tag CoIP
29507755
种属内
WTAP Q15007 SLIRP Homo sapiens Q9GZT3
Validated Y2H
32296183
种属内
WTAP Q15007 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
种属内
WTAP Q15007 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
种属内
WTAP Q15007 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
种属内
WTAP Q15007 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
种属内
WTAP Q15007 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
种属内
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
种属内
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
种属内
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
种属内
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
种属内
WTAP Q15007 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
种属内
WTAP Q15007 ABHD15 Homo sapiens Q6UXT9
Validated Y2H
32296183
种属内
WTAP Q15007 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
WTAP Q15007 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
种属内
WTAP Q15007 TNIP1 Homo sapiens Q15025
Validated Y2H
32296183
种属内
WTAP Q15007 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
种属内
WTAP Q15007 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
种属内
WTAP Q15007 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
种属内
WTAP Q15007 ZNF239 Homo sapiens Q16600
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

WTAP 抗体

目录号 产品名 应用 反应物种
HY-P81912 WTAP Antibody (YA1657) WB, IHC-P, IP Human
HY-P83721 WTAP Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Wilms Tumor 5

Wilms Tumor

WT5

Wilms Tumor Susceptibility-5

Wilms Tumor And Radial Bilateral Aplasia

Nephroblastoma

Wilms' Tumor

Wilms Tumor, Susceptibility To

Wtsl

Bilateral Radial Aplasia With Wilms Tumor

Embryonal Adenosarcoma

Embryonal Nephroma

Kidney Wilms Tumor

Kidney, Adenomyosarcoma, Embryonal

Kidney, Carcinosarcoma, Embryonal

Kidney, Embryoma

Kidney, Embryonal Mixed Tumor

Nephroma

Renal Adenosarcoma

Renal Cancer, Wilms

Renal Wilms Tumor

Tumor, Wilms

Hereditary Susceptibility To Wilms Tumor 5
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15854 WTAP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus WTAP RGD RGD:1563824
Mus musculus WTAP MGD MGI:1926395
Macaca mulatta WTAP VGNC VGNC:83971
Felis catus WTAP VGNC VGNC:84872
Canis familiaris WTAP VGNC VGNC:54003
Bos taurus WTAP VGNC VGNC:103059
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z