SLIRP - SRA stem-loop interacting RNA binding protein Gene

中文名称：SRA 茎环相互作用 RNA 结合蛋白

种属: Homo sapiens

同用名: DC50; PD04872; C14orf156

基因 ID: 81892 | 基因类型: protein coding

关于 SLIRP

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,708,071-77,717,598 (from NCBI)

This gene has 12 transcripts (splice variants), 173 orthologues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 31.5), kidney (RPKM 28.3) and 25 other tissues.

功能概要

类固醇受体 RNA 激活剂 (SRA，或 SRA1；MIM 603819) 是一种复杂的 RNA 分子，包含多个稳定的茎环结构，在核受体的共激活中发挥作用。 SLIRP 与 SRA (STR7) 的茎环结构 7 相互作用并调节核受体反式激活 (Hatchell 等人，2006 [PubMed 16762838]) 。[OMIM 提供，2008 年 3 月]

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).[supplied by OMIM, Mar 2008]

SLIRP 基因产物(3)

mRNA	Protein	Name
NM_001267863.1	NP_001254792.1	SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 2 precursor
NM_001267864.1	NP_001254793.1	SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 3 precursor
NM_031210.6	NP_112487.1	SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	22045337	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLIRP 蛋白结构

RRM_1

0
100
109 a.a.

蛋白主名

其他名称

SRA stem-loop-interacting RNA-binding protein, mitochondrial

SLIRP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SLIRP	Q9GZT3	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	SLIRP	Q9GZT3	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	SLIRP	Q9GZT3	LRPPRC	Homo sapiens	P42704	Anti Tag CoIP	33961781
Intra	SLIRP	Q9GZT3	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	AMOT	Homo sapiens	A2BDD9	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	AMOT	Homo sapiens	A2BDD9	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	SLIRP	Q9GZT3	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	SLIRP	Q9GZT3	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	STK40	Homo sapiens	Q8N2I9	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	STK40	Homo sapiens	Q8N2I9	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	SLIRP	Q9GZT3	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	SLIRP	Q9GZT3	WTAP	Homo sapiens	Q15007	Y2H Array	32296183
Intra	SLIRP	Q9GZT3	WTAP	Homo sapiens	Q15007	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SLIRP	Q9GZT3	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SLIRP	Q9GZT3	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mitochondrial Encephalomyopathy

Mitochondrial Encephalomyopathies

Encephalomyopathy, Mitochondrial

Mitochondrial Complex Iv Deficiency, Nuclear Type 5

Leigh Syndrome, French Canadian Type	Mitochondrial Complex V Deficiency Nuclear Type 4
Cytochrome C Oxidase Deficiency, French Canadian Type	Lsfc
Cox Deficiency, French Canadian Type	MC5DN4
MC4DN5	Cox Deficiency, Saguenay-Lac-Saint-Jean Type
Leigh Syndrome, Saguenay-Lac-Saint-Jean Type	Mitochondrial Complex V Deficiency, Nuclear Type 4
French Canadian Leigh Disease	Leigh Syndrome, French-Canadian Type
Leigh Syndrome , French Canadian Type	Mitochondrial Complex V Deficiency, Atp5a1 Type
French Canadian Type Cox Deficiency	French Canadian Type Cytochrome C Oxidase Deficiency
French Canadian Type Leigh Syndrome	Saguenay Lac Saint Jean Type Cox Deficiency
Saguenay Lac Saint Jean Type Leigh Syndrome	Cox Deficiency, Saguenay Lac Saint Jean Type
Leigh Syndrome, Saguenay Lac Saint Jean Type	Mitochondrial Complex V Deficiency, Nuclear Type 4
Mitochondrial Complex V Deficiency Atp5a1 Type	Mitochondrial Complex V Deficiency Type 4
Mitochondrial Complex V Deficiency, Nuclear, Type 4

Chromosome 13q14 Deletion Syndrome

Chromosome 13q Deletion Syndrome	Deletion 13q14
Chromosome 13q Deletion	13q Deletion
13q Monosomy	Deletion 13q
Monosomy 13q	Monosomy 13q14
Del(13)(Q14)

Leigh Syndrome

Leigh Disease	Infantile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency	LS
Sne	Leigh'S Disease
Leigh Syndrome Due To Mitochondrial Complex I Deficiency	Necrotizing Encephalopathy, Infantile Subacute, Of Leigh
Subacute Necrotizing Encephalomyelopathy	Necrotizing Encephalopathy Infantile Subacute Of Leigh
Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency	Infantile Necrotizing Encephalomyelopathy
Juvenile Subacute Necrotizing Encephalomyelopathy	Leigh'S Necrotizing Encephalopathy
Subacute Necrotizing Encephalopathy	Juvenile Subacute Necrotizing Encephalopathy
Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency	Leigh Syndrome Due To Mitochondrial Complex V Deficiency
Encephalopathy, Subacute Necrotizing, Infantile	Encephalopathy, Subacute Necrotizing, Juvenile
Maternally Inherited Leigh Syndrome	Subacute Necrotising Encephalomyelopathy
Subacute Necrotising Encephalopathy

Spastic Ataxia

Spax	Ataxia, Spastic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13369	SLIRP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	SLIRP	VGNC	VGNC:51688
Bos taurus	SLIRP	VGNC	VGNC:55144
Macaca mulatta	SLIRP	VGNC	VGNC:99241
Mus musculus	SLIRP	MGD	MGI:1916394
Rattus norvegicus	SLIRP	RGD	RGD:1585290

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