1. Gene
  2. NDUFAB1 - NADH:ubiquinone oxidoreductase subunit AB1 Gene

NDUFAB1 - NADH:ubiquinone oxidoreductase subunit AB1 Gene

中文名称:NADH:泛醌氧化还原酶亚基 AB1

种属: Homo sapiens

同用名: ACP; ACP1; SDAP; FASN2A

基因 ID: 4706 | 基因类型: protein coding

关于 NDUFAB1

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,581,014-23,596,316 (from NCBI)

This gene has 5 transcripts (splice variants), 236 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 68.8), colon (RPKM 46.1) and 25 other tissues.

功能概要

预测具有酰基结合活性;酰基载体活性;和脂肪酸结合活性。参与线粒体呼吸链复合物 I 组装和蛋白质脂化。位于线粒体和核质中。线粒体呼吸链复合体 I 的一部分。与线粒体大核糖体亚基共定位。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]

NDUFAB1 基因产物(1)

mRNA Protein Name
NM_005003.3 NP_004994.1 acyl carrier protein, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mitochondrial large ribosomal subunit binding IDA
IDA: 通过直接分析推断
28892042 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23157686 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in [2Fe-2S] cluster assembly IDA
IDA: 通过直接分析推断
31664822 GOA
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: 通过突变表型推断
27626371 GOA
involved in protein lipoylation IMP
IMP: 通过突变表型推断
21846720 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of mitochondrial [2Fe-2S] assembly complex IDA
IDA: 通过直接分析推断
31101807 GOA
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28844695 GOA
part of respiratory chain complex I IDA
IDA: 通过直接分析推断
12611891 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NDUFAB1 蛋白结构

PP-binding

PP-binding: Phosphopantetheine attachment site (92 - 148)

  • 0
  • 100
  • 156 a.a.
蛋白主名 其他名称

acyl carrier protein, mitochondrial

CI-SDAP

NDUFAB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NDUFAB1 O14561 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
32296183
Intra NDUFAB1 O14561 BEX5 Homo sapiens Q5H9J7
Validated Y2H
32296183
Intra NDUFAB1 O14561 BEX5 Homo sapiens Q5H9J7
Y2H Array
32296183
Intra NDUFAB1 O14561 BEX5 Homo sapiens Q5H9J7
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 SLIRP Homo sapiens Q9GZT3
Validated Y2H
32296183
Intra NDUFAB1 O14561 SLIRP Homo sapiens Q9GZT3
GMS
28892042
Intra NDUFAB1 O14561 CNTF Homo sapiens P26441
Validated Y2H
32296183
Intra NDUFAB1 O14561 CNTF Homo sapiens P26441
Y2H Array
32296183
Intra NDUFAB1 O14561 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra NDUFAB1 O14561 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra NDUFAB1 O14561 NRF1 Homo sapiens Q16656-4
Validated Y2H
32296183
Intra NDUFAB1 O14561 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra NDUFAB1 O14561 NOXA1 Homo sapiens Q86UR1-2
Validated Y2H
32296183
Intra NDUFAB1 O14561 TOX2 Homo sapiens Q96NM4-3
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 TOX2 Homo sapiens Q96NM4-3
Validated Y2H
32296183
Intra NDUFAB1 O14561 TOX2 Homo sapiens Q96NM4-3
Y2H Array
32296183
Intra NDUFAB1 O14561 ZNF19 Homo sapiens P17023
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 ZNF19 Homo sapiens P17023
Validated Y2H
32296183
Intra NDUFAB1 O14561 ZNF19 Homo sapiens P17023
Y2H Array
32296183
Intra NDUFAB1 O14561 BBC3 Homo sapiens Q96PG8
Validated Y2H
32296183
Intra NDUFAB1 O14561 ZNF829 Homo sapiens Q3KNS6-3
Y2H Array
32296183
Intra NDUFAB1 O14561 ZNF829 Homo sapiens Q3KNS6-3
Validated Y2H
32296183
Intra NDUFAB1 O14561 ZNF829 Homo sapiens Q3KNS6-3
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 VAC14 Homo sapiens Q08AM6
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 VAC14 Homo sapiens Q08AM6
Validated Y2H
32296183
Intra NDUFAB1 O14561 VAC14 Homo sapiens Q08AM6
Y2H Array
32296183
Intra NDUFAB1 O14561 FEM1A Homo sapiens Q9BSK4
Validated Y2H
32296183
Intra NDUFAB1 O14561 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra NDUFAB1 O14561 PSMC3 Homo sapiens P17980
Y2H Array
32296183
Intra NDUFAB1 O14561 PSMC3 Homo sapiens P17980
Validated Y2H
32296183
Intra NDUFAB1 O14561 PSMC3 Homo sapiens P17980
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 POP5 Homo sapiens Q969H6
Validated Y2H
32296183
Intra NDUFAB1 O14561 TLX3 Homo sapiens O43711
Validated Y2H
32296183
Intra NDUFAB1 O14561 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
Intra NDUFAB1 O14561 OIP5 Homo sapiens O43482
Validated Y2H
32296183
Intra NDUFAB1 O14561 PPP1R16A Homo sapiens Q96I34
Validated Y2H
32296183
Intra NDUFAB1 O14561 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra NDUFAB1 O14561 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra NDUFAB1 O14561 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra NDUFAB1 O14561 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra NDUFAB1 O14561 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra NDUFAB1 O14561 HINFP Homo sapiens Q9BQA5
Validated Y2H
32296183
Intra NDUFAB1 O14561 HINFP Homo sapiens Q9BQA5
Y2H Array
32296183
Intra NDUFAB1 O14561 HINFP Homo sapiens Q9BQA5
Y2H Prey Pooling
32296183
Intra NDUFAB1 O14561 MORN3 Homo sapiens Q6PF18
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Gonococcal Prostatitis

Gonococcal Prostatitis

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Leigh Syndrome

Leigh Disease

Infantile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

LS

Sne

Leigh'S Disease

Leigh Syndrome Due To Mitochondrial Complex I Deficiency

Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

Subacute Necrotizing Encephalomyelopathy

Necrotizing Encephalopathy Infantile Subacute Of Leigh

Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

Infantile Necrotizing Encephalomyelopathy

Juvenile Subacute Necrotizing Encephalomyelopathy

Leigh'S Necrotizing Encephalopathy

Subacute Necrotizing Encephalopathy

Juvenile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

Leigh Syndrome Due To Mitochondrial Complex V Deficiency

Encephalopathy, Subacute Necrotizing, Infantile

Encephalopathy, Subacute Necrotizing, Juvenile

Maternally Inherited Leigh Syndrome

Subacute Necrotising Encephalomyelopathy

Subacute Necrotising Encephalopathy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus NDUFAB1 VGNC VGNC:31952
Rattus norvegicus NDUFAB1 RGD RGD:1305619
Mus musculus NDUFAB1 MGD MGI:1917566