FHL3 - four and a half LIM domains 3 Gene

中文名称：四个半 LIM 域 3

种属: Homo sapiens

同用名: SLIM2

关于 FHL3

功能概要

由该基因编码的蛋白质是包含四个半 LIM 结构域的蛋白质家族的成员，该结构域是高度保守的双锌指基序。编码的蛋白质已被证明与癌症发育调节因子 SMAD2、SMAD3 和 SMAD4、骨骼肌成肌蛋白 MyoD 和高亲和力 IgE β 链调节因子 MZF-1 相互作用。该蛋白可能参与肿瘤抑制、MyoD 表达抑制和 IgE 受体表达抑制。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the Cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]