1. Gene
  2. TMEM108 - transmembrane protein 108 Gene

TMEM108 - transmembrane protein 108 Gene

中文名称:跨膜蛋白 108

种属: Homo sapiens

同用名: RTLN; CT124

基因 ID: 66000 | 基因类型: protein coding

关于 TMEM108

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,038,391-133,397,775 (from NCBI)

This gene has 11 transcripts (splice variants) and 181 orthologues. Broad expression in brain (RPKM 3.1), testis (RPKM 2.8) and 19 other tissues.

功能概要

预计参与多个过程,包括细胞对脑源性神经营养因子刺激的反应;神经系统发育;和信号转导的调节。预计位于体树突隔间。预计在轴突中活跃;核内体;和突触后密度。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in axon; endosome; and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]

TMEM108 基因产物(3)

mRNA Protein Name
NM_001136469.3 NP_001129941.1 transmembrane protein 108 isoform 1 precursor
NM_001282865.2 NP_001269794.1 transmembrane protein 108 isoform 2 precursor
NM_023943.4 NP_076432.1 transmembrane protein 108 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

transmembrane protein 108

cancer/testis antigen 124

TMEM108 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMEM108 Q6UXF1 FKBP7 Homo sapiens Q9Y680 32296183
种属内
TMEM108 Q6UXF1 FHL3 Homo sapiens Q13643 32296183
种属内
TMEM108 Q6UXF1 FHL3 Homo sapiens Q13643 32296183
种属内
TMEM108 Q6UXF1 SGTB Homo sapiens Q96EQ0 32296183
种属内
TMEM108 Q6UXF1 SGTB Homo sapiens Q96EQ0 32296183
种属内
TMEM108 Q6UXF1 SGTB Homo sapiens Q96EQ0 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease 18

AD18

Alzheimer'S Disease 18

Alzheimer Disease 18, Late-Onset

Alzheimer Disease 18, Susceptibility To

Alzheimer'S Disease 18, Late Onset

Alzheimer Disease 18 Late-Onset

Alzheimer Disease, Susceptibility To, Type 18

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TMEM108 VGNC VGNC:47449
Mus musculus TMEM108 MGD MGI:1932411
Felis catus TMEM108 VGNC VGNC:66258
Macaca mulatta TMEM108 VGNC VGNC:79714
Bos taurus TMEM108 VGNC VGNC:35948
Rattus norvegicus TMEM108 RGD RGD:1311530