1. Gene
  2. LNX2 - ligand of numb-protein X 2 Gene

LNX2 - ligand of numb-protein X 2 Gene

中文名称:num-protein X 2 的配体

种属: Homo sapiens

同用名: PDZRN1

基因 ID: 222484 | 基因类型: protein coding

关于 LNX2

Cytogenetic location: 13q12.2 Genomic coordinates (GRCh38): 13:27,545,913-27,621,107 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 9.5), small intestine (RPKM 7.4) and 25 other tissues.

功能概要

预计会启用泛素蛋白转移酶活性。预测参与蛋白质泛素化。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

LNX2 基因产物(1)

mRNA Protein Name
NM_153371.4 NP_699202.1 ligand of Numb protein X 2

LNX2 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (50 - 86)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (235 - 315)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (339 - 418)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (469 - 544)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (603 - 682)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
蛋白主名 其他名称

ligand of Numb protein X 2

PDZ domain containing ring finger 1

LNX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LNX2 Q8N448 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra LNX2 Q8N448 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra LNX2 Q8N448 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra LNX2 Q8N448 SCLY Homo sapiens Q96I15
Y2H
21516116
Intra LNX2 Q8N448 PEG10 Homo sapiens Q86TG7
Y2H
21516116
Intra LNX2 Q8N448 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra LNX2 Q8N448 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra LNX2 Q8N448 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra LNX2 Q8N448 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra LNX2 Q8N448 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra LNX2 Q8N448 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra LNX2 Q8N448 ATP5F1B Homo sapiens P06576
Y2H Array
29892012
Intra LNX2 Q8N448 ATP5F1B Homo sapiens P06576
Y2H Array
31515488
Cross LNX2 Q8N448 Hoxa1 Mus musculus P09022
Y2H
23088713
Cross LNX2 Q8N448 Hoxa1 Mus musculus P09022
Pull Down
23088713
Intra LNX2 Q8N448 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra LNX2 Q8N448 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra LNX2 Q8N448 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra LNX2 Q8N448 MYLIP Homo sapiens Q8WY64
Y2H Array
31515488
Intra LNX2 Q8N448 PAAT Homo sapiens Q9H8K7
Y2H Array
31515488
Intra LNX2 Q8N448 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra LNX2 Q8N448 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra LNX2 Q8N448 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra LNX2 Q8N448 PTCD3 Homo sapiens Q96EY7
Y2H
21516116
Intra LNX2 Q8N448 FHL3 Homo sapiens Q13643
Validated Y2H
27107012
Intra LNX2 Q8N448 IP6K2 Homo sapiens Q9UHH9
Y2H
21516116
Intra LNX2 Q8N448 OPTN Homo sapiens Q96CV9
Y2H
21516116
Intra LNX2 Q8N448 PHYKPL Homo sapiens Q8IUZ5
Y2H Array
31515488
Intra LNX2 Q8N448 CBX5 Homo sapiens P45973
Y2H Array
32814053
Intra LNX2 Q8N448 CBX5 Homo sapiens P45973
Y2H Pooling
32814053
Intra LNX2 Q8N448 CBX5 Homo sapiens P45973
Validated Y2H
32814053
Cross LNX2 Q8N448 tax Human T-cell leukemia virus P03410
Y2H Pooling
22458338
Cross LNX2 Q8N448 tax Human T-cell leukemia virus P03410
Y2H Array
22458338
Cross LNX2 Q8N448 rex_htl1c Human T-cell leukemia virus 1 P0C206
Y2H Pooling
22458338
Cross LNX2 Q8N448 rex_htl1c Human T-cell leukemia virus 1 P0C206
Y2H Array
22458338
Cross LNX2 Q8N448 tax Human T-cell leukemia virus 1 P14079
Y2H Array
22458338
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Q Fever

Infection Due To Coxiella Burnetii

Quadrilateral Fever

Query Fever

Nine Mile Fever

Coxiella Burnetii Fever

Q Fever Pneumonia

Coxiellosis

Pneumonia In Q Fever

Australian Q Fever

Balkan Grippe

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia

XLN

SCNX

Severe Congenital Neutropenia X-Linked

Neutropenia, Congenital, Severe, X-Linked

Hyperekplexia

Hereditary Hyperekplexia

Kok Disease

Congenital Stiff Man Syndrome

Familial Startle Disease

Sthe

Stiff-Baby Syndrome

Hereditary Hyperexplexia

Startle Disease

Exaggerated Startle Reaction

Hyperexplexia Hereditary

Startle Disease, Familial

Startle Reaction, Exaggerated

Stiff-Man Syndrome, Congenital

Stiff-Person Syndrome, Congenital

Congenital Stiff-Man Syndrome

Congenital Stiff-Person Syndrome

Familial Hyperekplexia

Startle Syndrome

Stiff Baby Syndrome

Hyperekplexia, Hereditary

Stiff-Person Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LNX2 RGD RGD:1308222
Macaca mulatta LNX2 VGNC VGNC:106268
Felis catus LNX2 VGNC VGNC:63254
Bos taurus LNX2 VGNC VGNC:30946
Canis familiaris LNX2 VGNC VGNC:42732
Mus musculus LNX2 MGD MGI:2155959