CBX5 - chromobox 5 Gene

中文名称：色盒 5

种属: Homo sapiens

同用名: HP1; HP1A; HEL25

基因 ID: 23468 | 基因类型: protein coding

关于 CBX5

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,230,942-54,280,122 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 15.3), thyroid (RPKM 14.2) and 25 other tissues.

功能概要

该基因编码一种高度保守的非组蛋白，它是异染色质蛋白家族的一员。该蛋白质富含异染色质并与着丝粒相关。该蛋白质具有一个 N 端染色质域，可通过甲基化赖氨酸残基与组蛋白结合，以及一个 C 端染色质阴影域 (CSD) ，负责同源二聚化以及与许多染色质相关非组蛋白的相互作用。编码产物通过与必需的着丝粒蛋白相互作用参与功能性着丝粒的形成。该基因在 3 号染色体上有一个假基因。已鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

CBX5 基因产物(3)

mRNA	Protein	Name
NM_001127321.1	NP_001120793.1	chromobox protein homolog 5
NM_001127322.1	NP_001120794.1	chromobox protein homolog 5
NM_012117.3	NP_036249.1	chromobox protein homolog 5

CBX5 蛋白结构

Chromo

Chromo_shadow

0
100
191 a.a.

蛋白主名

其他名称

chromobox protein homolog 5

HP1 alpha homolog

CBX5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	Anti Tag CoIP	20562864
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	Y2H	20562864
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	Anti Tag CoIP	19498464
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	TAP	24981860
Intra	CBX5	P45973	CHAF1A	Homo sapiens	Q13111	TAP	27705803
Intra	CBX5	P45973	LBR	Homo sapiens	Q14739	Pull Down	8663349
Intra	CBX5	P45973	MFSD10	Homo sapiens	Q14728	Y2H Array	32814053
Intra	CBX5	P45973	MFSD10	Homo sapiens	Q14728	Y2H Pooling	32814053
Intra	CBX5	P45973	MFSD10	Homo sapiens	Q14728	Validated Y2H	32814053
Intra	CBX5	P45973	ZNF280D	Homo sapiens	Q6N043-2	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	ZNF280D	Homo sapiens	Q6N043-2	Y2H Array	32296183
Intra	CBX5	P45973	ZNF280D	Homo sapiens	Q6N043-2	Validated Y2H	32296183
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	Anti Tag CoIP	19498464
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	Anti Tag CoIP	20562864
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	TAP	24981860
Intra	CBX5	P45973	POGZ	Homo sapiens	Q7Z3K3	TAP	27705803
Intra	CBX5	P45973	ADNP	Homo sapiens	Q9H2P0	TAP	27705803
Intra	CBX5	P45973	ADNP	Homo sapiens	Q9H2P0	Anti Tag CoIP	20562864
Intra	CBX5	P45973	ATG13	Homo sapiens	O75143-2	Validated Y2H	32814053
Intra	CBX5	P45973	ATG13	Homo sapiens	O75143-2	Y2H Array	32814053
Intra	CBX5	P45973	ATG13	Homo sapiens	O75143-2	Y2H Pooling	32814053
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95-3	Validated Y2H	32814053
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95-3	Y2H Array	32814053
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95-3	Y2H Pooling	32814053
Intra	CBX5	P45973	LAP3	Homo sapiens	P28838	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Y2H Pooling	32814053
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	TAP	24981860
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	TAP	27705803
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	20562864
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Validated Y2H	32814053
Intra	CBX5	P45973	NSL1	Homo sapiens	Q96IY1	Y2H Array	32814053
Intra	CBX5	P45973	PIGV	Homo sapiens	Q9NUD9	Validated Y2H	32814053
Intra	CBX5	P45973	PIGV	Homo sapiens	Q9NUD9	Y2H Array	32814053
Intra	CBX5	P45973	PIGV	Homo sapiens	Q9NUD9	Y2H Pooling	32814053
Intra	CBX5	P45973	ARFGAP3	Homo sapiens	Q9NP61	Validated Y2H	32814053
Intra	CBX5	P45973	ARFGAP3	Homo sapiens	Q9NP61	Y2H Array	32814053
Intra	CBX5	P45973	ARFGAP3	Homo sapiens	Q9NP61	Y2H Pooling	32814053
Intra	CBX5	P45973	H4C16	Homo sapiens	P62805	TAP	24981860
Intra	CBX5	P45973	H4C16	Homo sapiens	P62805	Crosslink	30021884
Intra	CBX5	P45973	H4C16	Homo sapiens	P62805	TAP	21888893
Intra	CBX5	P45973	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	20562864
Intra	CBX5	P45973	INCENP	Homo sapiens	Q9NQS7	Pull Down	21346195
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95	Y2H	21516116
Intra	CBX5	P45973	NSD3	Homo sapiens	Q9BZ95	Lumier	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Validated Y2H	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Array	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Anti Tag CoIP	20562864
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Pooling	32814053
Intra	CBX5	P45973	SUV39H1	Homo sapiens	O43463	Y2H Array	32296183
Intra	CBX5	P45973	H3-4	Homo sapiens	Q16695	TAP	21888893
Intra	CBX5	P45973	ATRX	Homo sapiens	P46100	Anti Bait CoIP	10699177
Intra	CBX5	P45973	MYC	Homo sapiens	P01106	Y2H Pooling	32814053
Intra	CBX5	P45973	MYC	Homo sapiens	P01106	Validated Y2H	32814053
Intra	CBX5	P45973	MYC	Homo sapiens	P01106	Y2H Array	32814053
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Anti Tag CoIP	23542155
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	TAP	27705803
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32296183
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Anti Tag CoIP	20562864
Intra	CBX5	P45973	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
Intra	CBX5	P45973	SP100	Homo sapiens	P23497-2	BFG-2H	27107012
Intra	CBX5	P45973	SP100	Homo sapiens	P23497-2	Validated Y2H	27107012
Intra	CBX5	P45973	DDX19B	Homo sapiens	Q9UMR2	Y2H Array	32814053
Intra	CBX5	P45973	DDX19B	Homo sapiens	Q9UMR2	Validated Y2H	32814053
Intra	CBX5	P45973	DDX19B	Homo sapiens	Q9UMR2	Y2H Pooling	32814053
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Prey Pooling	32296183
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Anti Tag CoIP	20562864
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	TAP	27705803
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Array	31515488
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Pooling	16189514
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Validated Y2H	32296183
Intra	CBX5	P45973	PRR14	Homo sapiens	Q9BWN1	Y2H Array	32296183
Intra	CBX5	P45973	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Array	32814053
Intra	CBX5	P45973	TRAF3IP3	Homo sapiens	Q9Y228	Y2H Pooling	32814053
Intra	CBX5	P45973	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32814053
Intra	CBX5	P45973	SENP7	Homo sapiens	Q9BQF6	Anti Tag CoIP	20562864
Intra	CBX5	P45973	SENP7	Homo sapiens	Q9BQF6	TAP	27705803
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	TAP	24981860
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	TAP	27705803
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	TAP	21888893
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	Anti Tag CoIP	20562864
Intra	CBX5	P45973	TRIM28	Homo sapiens	Q13263	Anti Tag CoIP	19498464
Intra	CBX5	P45973	PPARA	Homo sapiens	Q07869	Y2H Array	32814053
Intra	CBX5	P45973	PPARA	Homo sapiens	Q07869	Validated Y2H	32814053
Intra	CBX5	P45973	PPARA	Homo sapiens	Q07869	Y2H Pooling	32814053
Intra	CBX5	P45973	H3C1	Homo sapiens	P68431	Pull Down	16415788
Intra	CBX5	P45973	H3C1	Homo sapiens	P68431	Protein Array	20871592
Intra	CBX5	P45973	MBD1	Homo sapiens	Q9UIS9	Anti Bait CoIP	12711603
Intra	CBX5	P45973	MBD1	Homo sapiens	Q9UIS9	Pull Down	12711603
Intra	CBX5	P45973	MBD1	Homo sapiens	Q9UIS9	Confocal	12711603
Intra	CBX5	P45973	ZNF280C	Homo sapiens	Q8ND82	Validated Y2H	32296183
Cross	CBX5	P45973	legAS4	Legionella pneumophila subsp. pneumophila	Q5ZUS4	Y2H	23797873
Cross	CBX5	P45973	legAS4	Legionella pneumophila subsp. pneumophila	Q5ZUS4	Anti Bait CoIP	23797873
Intra	CBX5	P45973	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	CBX5	P45973	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	CBX5	P45973	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053
Intra	CBX5	P45973	SGO1	Homo sapiens	Q5FBB7	TAP	24981860
Intra	CBX5	P45973	SGO1	Homo sapiens	Q5FBB7	Anti Tag CoIP	20562864

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Reynolds Syndrome

Primary Biliary Cirrhosis, Scleroderma, Raynaud Disease, And Telangiectasia	Primary Biliary Cirrhosis And Systemic Scleroderma
REYNS	Primary Biliary Cirrhosis Scleroderma Raynaud Disease And Telangiectasia

Hutchinson-Gilford Progeria Syndrome

Progeria	HGPS
Hutchinson-Gilford Syndrome	Hutchinson-Gilford Progeria
Hutchinson Gilford Syndrome	Hutchinson Gilford Progeria Syndrome
Hutchinson-Gilford Disease	Progeria Of Childhood
Hutchinson-Gilford-Progeria Syndrome

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Hyperoxaluria, Primary, Type I

Primary Hyperoxaluria Type 1	HP1
Glycolic Aciduria	Alanine-Glyoxylate Aminotransferase Deficiency
Hepatic Agt Deficiency	Oxalosis I
Primary Hyperoxaluria, Type I	Serine:Pyruvate Aminotransferase Deficiency
Hyperoxaluria, Primary, Type 1	Peroxisomal Alanine-Glyoxylate Aminotransferase Deficiency
Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency	Serine Pyruvate Aminotransferase Deficiency
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Oxalosis 1
Hyperoxaluria Primary 1	Hyperoxaluria Primary Type I
Ph1	Primary Hyperoxaluria Type I
Oxalosis Type 1	2-Oxoglutarate Glyoxylate Carboligase Deficiency

Primary Hyperoxaluria

Hyperoxaluria	Hyperoxaluria, Primary
Oxalosis	Primary Oxalosis
Congenital Oxaluria	D-Glycerate Dehydrogenase Deficiency
Glyceric Aciduria	Glycolic Aciduria
Hepatic Agt Deficiency	Oxaluria, Primary
Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency	Primary Oxaluria
Hyperoxaluria Primary	Primary Hyperoxaluria Type 2
Primary Hyperoxaluria, Type I

Alpha Thalassemia-X-Linked Intellectual Disability Syndrome

Atr-X Syndrome	Atr, Nondeletion Type
Alpha-Thalassemia X-Linked Intellectual Disability Syndrome	Atrx Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type	Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked
X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome	Xlmr Hypotonic Face Syndrome
Alpha Thalassemia X-Linked Intellectual Disability Syndrome	Alpha Thalassemia X-Linked Mental Retardation Syndrome
Alpha Thalassemia/Mental Retardation, X-Linked	Alpha-Thalassemia X-Linked Mental Retardation Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type	X-Linked Alpha-Thalassemia/Mental Retardation Syndrome
Xlmr-Hypotonic Face Syndrome	Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked

White-Sutton Syndrome

WHSUS	Mrd37
Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome	Mental Retardation, Autosomal Dominant 37
Autosomal Dominant Mental Retardation 37	Pogz-Related Intellectual Disability Syndrome

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-142952	UNC6864 (Kei)	Inhibitor	/	否
HY-142953	UNC6349 (Ket2)	Inhibitor	/	否
HY-142954	UNC6212 (Kme2)	Inhibitor	/	否
HY-RS02012	CBX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CBX5	VGNC	VGNC:70559
Rattus norvegicus	CBX5	RGD	RGD:1306619
Bos taurus	CBX5	VGNC	VGNC:26818
Canis familiaris	CBX5	VGNC	VGNC:38767
Mus musculus	CBX5	MGD	MGI:109372

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