ARFGAP3 - ADP ribosylation factor GTPase activating protein 3 Gene

中文名称：ADP 核糖基化因子 GTP 酶激活蛋白 3

种属: Homo sapiens

同用名: ARFGAP1

基因 ID: 26286 | 基因类型: protein coding

关于 ARFGAP3

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,796,502-42,857,273 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 28 paralogues. Ubiquitous expression in adrenal (RPKM 47.6), prostate (RPKM 36.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 GTP 酶激活蛋白 (GAP) ，它与高尔基体结合并调节蛋白质的早期分泌途径。编码的蛋白质促进 ADP-核糖基化因子 1 (ARF1) 结合的 GTP 的水解，这是外壳蛋白从高尔基体衍生的膜和囊泡中解离所必需的。外壳蛋白的解离是这些囊泡与目标隔室融合的先决条件。这种蛋白质的活性对磷脂敏感。已发现该基因编码不同异构体的多个转录变体。该基因最初被称为 ARFGAP1，但现在是一个相关但不同的基因的名称。[RefSeq 提供，2008 年 11 月]

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to Phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]

ARFGAP3 基因产物(2)

mRNA	Protein	Name
NM_001142293.2	NP_001135765.1	ADP-ribosylation factor GTPase-activating protein 3 isoform 2
NM_014570.5	NP_055385.3	ADP-ribosylation factor GTPase-activating protein 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activator activity	IDA IDA: 通过直接分析推断	11172815	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23275563	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in protein secretion	IEP IEP: 通过表达模式推断	11172815	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	11172815	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARFGAP3 蛋白结构

ArfGap

0
100
200
300
400
516 a.a.

蛋白主名

其他名称

ADP-ribosylation factor GTPase-activating protein 3

ADP-ribosylation factor GTPase activating protein 1

ARFGAP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARFGAP3	Q9NP61	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	BACE2	Homo sapiens	Q9Y5Z0	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	BACE2	Homo sapiens	Q9Y5Z0	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	BACE2	Homo sapiens	Q9Y5Z0	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	SYPL1	Homo sapiens	Q16563	Y2H Prey Pooling	32296183
种属内	ARFGAP3	Q9NP61	SYPL1	Homo sapiens	Q16563	Y2H Array	32296183
种属内	ARFGAP3	Q9NP61	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
种属内	ARFGAP3	Q9NP61	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
种属内	ARFGAP3	Q9NP61	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	CCT5	Homo sapiens	P48643	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	HTT	Homo sapiens	P42858	Lumier	23275563
种属内	ARFGAP3	Q9NP61	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	NEFL	Homo sapiens	P07196	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
种属内	ARFGAP3	Q9NP61	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
种属内	ARFGAP3	Q9NP61	PTGS1	Homo sapiens	P23219	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	PTGS1	Homo sapiens	P23219	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	PTGS1	Homo sapiens	P23219	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	TTR	Homo sapiens	P02766	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	TTR	Homo sapiens	P02766	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	CDH1	Homo sapiens	A5D8W4	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	CDH1	Homo sapiens	A5D8W4	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	CDH1	Homo sapiens	A5D8W4	Y2H Array	32814053
种属内	ARFGAP3	Q9NP61	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
种属内	ARFGAP3	Q9NP61	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
种属内	ARFGAP3	Q9NP61	PEX1	Homo sapiens	O43933	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Ceroid Lipofuscinosis, Neuronal, 4

Ceroid Lipofuscinosis, Neuronal, Parry Type	Cln4b Disease
Neuronal Ceroid Lipofuscinosis 4b	CLN4B
Autosomal Dominant Neuronal Ceroid Lipofuscinosis 4b	Ceroid Lipofuscinosis, Neuronal, 4b, Autosomal Dominant
Adult Neuronal Ceroid Lipofuscinosis	CLN4
Ceroid Lipofuscinosis, Neuronal, 4 , Autosomal Dominant	Neuronal Ceroid Lipofuscinosis 4
Neuronal Ceroid Lipofuscinosis 4 Parry Type	Adult Neuronal Ceroid Lipofuscinosis 4b
Kuf'S Disease Type B	Kuf'S Disease, Autosomal Dominant
Cln4 Disease	Parry Disease
Ceroid Lipofuscinosis, Neuronal 4	Ceroid Lipofuscinosis, Neuronal, 4b , Autosomal Dominant
Kufs Disease Autosomal Dominant	Neuronal Ceroid Lipofuscinosis Parry Type
Ceroid Lipofuscinosis, Neuronal, 4, Parry Type	Lipofuscinosis, Ceroid, Neuronal, Type 4, Parry Type

Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS	Hypotrichosis Lymphedema Telangiectasia Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome	Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Pelvic Organ Prolapse

Rectal Prolapse	Pelvic Organ Prolapse, Susceptibility To, 1
Pelvic Organ Prolapse, Susceptibility To	Prolapse Of Vagina And Rectum
Vaginal Prolapse	Pelvic Organ Prolapse 1
Procidentia, Rectum	Prolapse Of Rectal Mucosa
Procidentia Of Rectum	Rectal Mucosa Prolapse
Rectum Prolapse	Procidentia Rectum
Rp - [Rectal Prolapse]	Male Proctocele
Male Rectocele	Proctoptosis
Female Genital Prolapse	Female Prolapse
Incompetence Of Pelvic Fundus	Relaxation Of Perineum
Deficiency Of Perineum

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00901	ARFGAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ARFGAP3	VGNC	VGNC:38034
Rattus norvegicus	ARFGAP3	RGD	RGD:1560066
Bos taurus	ARFGAP3	VGNC	VGNC:26063
Mus musculus	ARFGAP3	MGD	MGI:1913501
Macaca mulatta	ARFGAP3	VGNC	VGNC:70002
Felis catus	ARFGAP3	VGNC	VGNC:68050

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARFGAP3 - ADP ribosylation factor GTPase activating protein 3 Gene

关于 ARFGAP3

功能概要

ARFGAP3 基因产物(2)

ARFGAP3 蛋白结构

ARFGAP3 蛋白互作信息

关联疾病

直系同源

热门区域

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ARFGAP3 - ADP ribosylation factor GTPase activating protein 3 Gene

关于 ARFGAP3

功能概要

ARFGAP3 基因产物(2)

ARFGAP3 蛋白结构

ARFGAP3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

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Q

S

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