1. Gene
  2. LIME1 - Lck interacting transmembrane adaptor 1 Gene

LIME1 - Lck interacting transmembrane adaptor 1 Gene

中文名称:Lck 交互跨膜适配器 1

种属: Homo sapiens

同用名: LIME; dJ583P15.4

基因 ID: 54923 | 基因类型: protein coding

关于 LIME1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,735,701-63,739,103 (from NCBI)

This gene has 10 transcripts (splice variants), 76 orthologues and 2 paralogues. Broad expression in kidney (RPKM 23.8), liver (RPKM 18.5) and 21 other tissues.

功能概要

该基因编码跨膜衔接蛋白,该蛋白分别通过与 Src 家族激酶 Lck 和 Lyn 的关联,将 T 和 B 细胞受体刺激与下游信号通路联系起来。该基因的可变剪接导致多个转录变体。[RefSeq 提供,2015 年 3 月]

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

LIME1 基因产物(3)

mRNA Protein Name
NM_001305654.2 NP_001292583.1 lck-interacting transmembrane adapter 1 isoform 2 precursor
NM_001305655.2 NP_001292584.1 lck-interacting transmembrane adapter 1 isoform 2 precursor
NM_017806.4 NP_060276.2 lck-interacting transmembrane adapter 1 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LIME1 蛋白结构

LIME1

LIME1: Lck-interacting transmembrane adapter 1 (27 - 259)

  • 0
  • 100
  • 200
  • 295 a.a.
蛋白主名 其他名称

lck-interacting transmembrane adapter 1

lck-interacting membrane protein

LIME1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LIME1 Q9H400 PNPO Homo sapiens Q9NVS9
Validated Y2H
32296183
Intra LIME1 Q9H400 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra LIME1 Q9H400 NDRG4 Homo sapiens Q9ULP0-2
Validated Y2H
32296183
Intra LIME1 Q9H400 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra LIME1 Q9H400 MAN2B2 Homo sapiens Q9Y2E5
Validated Y2H
32296183
Intra LIME1 Q9H400 ARFGAP3 Homo sapiens Q9NP61
Validated Y2H
32296183
Intra LIME1 Q9H400 TRAF7 Homo sapiens Q6Q0C0
Anti Tag CoIP
33961781
Intra LIME1 Q9H400 CLN6 Homo sapiens Q9NWW5
Validated Y2H
32296183
Intra LIME1 Q9H400 CIAO2A Homo sapiens Q9H5X1
Validated Y2H
32296183
Intra LIME1 Q9H400 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LIME1 RGD RGD:1562795
Mus musculus LIME1 MGD MGI:1919949