2. Gene
  3. LPAR3 - lysophosphatidic acid receptor 3 Gene

LPAR3 - lysophosphatidic acid receptor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酸受体 3

种属: Homo sapiens

同用名: EDG7; GPCR; LPA3; Edg-7; LP-A3; HOFNH30; RP4-678I3

基因 ID: 23566 | 基因类型: protein coding

关于 LPAR3

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,811,602-84,893,206 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 18 paralogues. Biased expression in prostate (RPKM 8.7), testis (RPKM 8.1) and 12 other tissues.

功能概要

该基因编码 G 蛋白偶联受体家族以及 EDG 蛋白家族的成员。这种蛋白质作为溶血磷脂酸的细胞受体起作用，并介导溶血磷脂酸诱发的钙动员。该受体主要与 G (q/11) α 蛋白结合。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]

LPAR3 基因产物(1)

mRNA Protein Name
NM_012152.3 NP_036284.1 lysophosphatidic acid receptor 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LPAR3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (48 - 293)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 3

LPA receptor 3

LPA receptor EDG7

LPA-3

calcium-mobilizing lysophosphatidic acid receptor LP-A3

endothelial cell differentiation gene 7

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7

lysophosphatidic acid receptor Edg-7

LPAR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LPAR3 Q9UBY5 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra LPAR3 Q9UBY5 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra LPAR3 Q9UBY5 RELL2 Homo sapiens Q8NC24
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 RELL2 Homo sapiens Q8NC24
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM41A Homo sapiens Q96HV5
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 TMEM41A Homo sapiens Q96HV5
Y2H Array
32296183
Intra LPAR3 Q9UBY5 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra LPAR3 Q9UBY5 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 SGMS2 Homo sapiens Q8NHU3
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 SGMS2 Homo sapiens Q8NHU3
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra LPAR3 Q9UBY5 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra LPAR3 Q9UBY5 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra LPAR3 Q9UBY5 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra LPAR3 Q9UBY5 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TFEC Homo sapiens O14948-3
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CLEC12B Homo sapiens Q2HXU8-2
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CLEC12B Homo sapiens Q2HXU8-2
Y2H Array
32296183
Intra LPAR3 Q9UBY5 MS4A4A Homo sapiens Q96JQ5
Y2H Array
32296183
Intra LPAR3 Q9UBY5 MS4A4A Homo sapiens Q96JQ5
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 KCNC1 Homo sapiens P48547
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 KCNC1 Homo sapiens P48547
Y2H Array
32296183
Intra LPAR3 Q9UBY5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra LPAR3 Q9UBY5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra LPAR3 Q9UBY5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra LPAR3 Q9UBY5 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra LPAR3 Q9UBY5 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra LPAR3 Q9UBY5 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 C16orf54 Homo sapiens Q6UWD8
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 C16orf54 Homo sapiens Q6UWD8
Y2H Array
32296183
Intra LPAR3 Q9UBY5 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CLDN9 Homo sapiens O95484
Y2H Array
32296183
Intra LPAR3 Q9UBY5 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra LPAR3 Q9UBY5 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra LPAR3 Q9UBY5 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra LPAR3 Q9UBY5 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra LPAR3 Q9UBY5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra LPAR3 Q9UBY5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra LPAR3 Q9UBY5 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra LPAR3 Q9UBY5 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra LPAR3 Q9UBY5 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra LPAR3 Q9UBY5 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM70 Homo sapiens Q9BUB7
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM70 Homo sapiens Q9BUB7
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 THAP4 Homo sapiens Q8WY91
Y2H Array
32296183
Intra LPAR3 Q9UBY5 THAP4 Homo sapiens Q8WY91
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra LPAR3 Q9UBY5 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 LEPROTL1 Homo sapiens O95214
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 LEPROTL1 Homo sapiens O95214
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CLDN2 Homo sapiens P57739
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CLDN2 Homo sapiens P57739
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra LPAR3 Q9UBY5 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra LPAR3 Q9UBY5 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra LPAR3 Q9UBY5 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Intra LPAR3 Q9UBY5 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM79 Homo sapiens Q9BSE2
Y2H Array
32296183
Intra LPAR3 Q9UBY5 TMEM79 Homo sapiens Q9BSE2
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson-Gilford Disease

Hutchinson Gilford Progeria Syndrome

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome
Trachea Carcinoma

Pancoast Tumor

Carcinoma Of The Trachea

Pancoast'S Tumor

Malignant Superior Sulcus Tumor

Malignant Superior Sulcus Tumour

Pancoast Tumour

Pancoast'S Syndrome

Pancoast'S Tumour

Pulmonary Sulcus Tumor

Pulmonary Sulcus Tumour

Superior Pulmonary Sulcus Syndrome

Pancoast Syndrome
Triple-Receptor Negative Breast Cancer
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Tracheal Cancer

Tracheal Carcinoma

Malignant Neoplasm Of Trachea

Tracheal Neoplasms

Pancoast Tumor

Pulmonary Sulcus Neoplasm

Pancoast Syndrome
Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15706 H2L 5765834 Antagonist 98.36% 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LPAR3 VGNC VGNC:63263
Macaca mulatta LPAR3 VGNC VGNC:74287
Canis familiaris LPAR3 VGNC VGNC:42744
Mus musculus LPAR3 MGD MGI:1929469
Bos taurus LPAR3 VGNC VGNC:30957
Rattus norvegicus LPAR3 RGD RGD:620565
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z