2. Gene
  3. LEPROTL1 - leptin receptor overlapping transcript like 1 Gene

LEPROTL1 - leptin receptor overlapping transcript like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：瘦素受体重叠转录物样 1

种属: Homo sapiens

同用名: Vps55; my047; HSPC112

基因 ID: 23484 | 基因类型: protein coding

关于 LEPROTL1

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,095,408-30,138,348 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues, 1 paralogue and is associated with 55 phenotypes. Ubiquitous expression in placenta (RPKM 29.1), lymph node (RPKM 17.8) and 24 other tissues.

功能概要

实现相同的蛋白质结合活性。预计通过多泡体分选途径和生长激素受体信号通路的负调节参与晚期内体到液泡的运输。预计是膜的组成部分。预计在内体中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and negative regulation of growth hormone receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]

LEPROTL1 基因产物(2)

mRNA Protein Name
NM_001128208.2 NP_001121680.1 leptin receptor overlapping transcript-like 1 isoform 2
NM_015344.3 NP_056159.2 leptin receptor overlapping transcript-like 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LEPROTL1 蛋白结构

Vps55

Vps55: Vacuolar protein sorting 55 (7 - 125)

  • 0
  • 100
  • 131 a.a.
蛋白主名 其他名称

leptin receptor overlapping transcript-like 1

endospanin-2

LEPROTL1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LEPROTL1 O95214 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra LEPROTL1 O95214 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra LEPROTL1 O95214 SLC25A46 Homo sapiens Q96AG3
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra LEPROTL1 O95214 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra LEPROTL1 O95214 CISD2 Homo sapiens Q8N5K1
Validated Y2H
32296183
Intra LEPROTL1 O95214 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 ORMDL1 Homo sapiens Q9P0S3
Validated Y2H
32296183
Intra LEPROTL1 O95214 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra LEPROTL1 O95214 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra LEPROTL1 O95214 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra LEPROTL1 O95214 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra LEPROTL1 O95214 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra LEPROTL1 O95214 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra LEPROTL1 O95214 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra LEPROTL1 O95214 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra LEPROTL1 O95214 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
Intra LEPROTL1 O95214 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM42 Homo sapiens Q69YG0
Validated Y2H
32296183
Intra LEPROTL1 O95214 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM50B Homo sapiens P56557
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 TMEM50B Homo sapiens P56557
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM50B Homo sapiens P56557
Y2H Array
32296183
Intra LEPROTL1 O95214 TGFA Homo sapiens P01135-2
Y2H Array
32296183
Intra LEPROTL1 O95214 TGFA Homo sapiens P01135-2
Validated Y2H
32296183
Intra LEPROTL1 O95214 TGFA Homo sapiens P01135-2
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 FMO1 Homo sapiens Q01740
Validated Y2H
32296183
Intra LEPROTL1 O95214 FMO1 Homo sapiens Q01740
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 FMO1 Homo sapiens Q01740
Y2H Array
32296183
Intra LEPROTL1 O95214 ZDHHC15 Homo sapiens Q96MV8
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 ZDHHC15 Homo sapiens Q96MV8
Validated Y2H
32296183
Intra LEPROTL1 O95214 ZDHHC15 Homo sapiens Q96MV8
Y2H Array
32296183
Intra LEPROTL1 O95214 PAQR8 Homo sapiens Q8TEZ7
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM50A Homo sapiens O95807
Validated Y2H
32296183
Intra LEPROTL1 O95214 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra LEPROTL1 O95214 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra LEPROTL1 O95214 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
Intra LEPROTL1 O95214 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 REEP6 Homo sapiens Q96HR9-2
Validated Y2H
32296183
Intra LEPROTL1 O95214 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra LEPROTL1 O95214 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra LEPROTL1 O95214 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra LEPROTL1 O95214 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra LEPROTL1 O95214 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra LEPROTL1 O95214 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra LEPROTL1 O95214 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 GJA8 Homo sapiens P48165
Validated Y2H
32296183
Intra LEPROTL1 O95214 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra LEPROTL1 O95214 CYP4F2 Homo sapiens P78329
Validated Y2H
32296183
Intra LEPROTL1 O95214 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra LEPROTL1 O95214 MSR1 Homo sapiens P21757
Y2H Array
31515488
Intra LEPROTL1 O95214 MSR1 Homo sapiens P21757
Validated Y2H
32296183
Intra LEPROTL1 O95214 MSR1 Homo sapiens P21757
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 MSR1 Homo sapiens P21757
Y2H Array
32296183
Intra LEPROTL1 O95214 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra LEPROTL1 O95214 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra LEPROTL1 O95214 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra LEPROTL1 O95214 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 EHHADH Homo sapiens Q08426
Validated Y2H
32296183
Intra LEPROTL1 O95214 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra LEPROTL1 O95214 STING1 Homo sapiens Q86WV6
Validated Y2H
32296183
Intra LEPROTL1 O95214 STING1 Homo sapiens Q86WV6
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 STING1 Homo sapiens Q86WV6
Y2H Array
32296183
Intra LEPROTL1 O95214 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra LEPROTL1 O95214 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra LEPROTL1 O95214 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra LEPROTL1 O95214 RBFA Homo sapiens Q8N0V3
Validated Y2H
32296183
Intra LEPROTL1 O95214 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra LEPROTL1 O95214 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra LEPROTL1 O95214 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra LEPROTL1 O95214 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra LEPROTL1 O95214 CD300C Homo sapiens Q08708
Validated Y2H
32296183
Intra LEPROTL1 O95214 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra LEPROTL1 O95214 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Intra LEPROTL1 O95214 SLC7A1 Homo sapiens P30825
Validated Y2H
32296183
Intra LEPROTL1 O95214 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra LEPROTL1 O95214 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra LEPROTL1 O95214 EMP1 Homo sapiens P54849
Y2H Array
32296183
Intra LEPROTL1 O95214 JPH1 Homo sapiens Q9HDC5
Validated Y2H
32296183
Intra LEPROTL1 O95214 JPH1 Homo sapiens Q9HDC5
Y2H Array
32296183
Intra LEPROTL1 O95214 JPH1 Homo sapiens Q9HDC5
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 EDA Homo sapiens Q92838
Y2H Array
31515488
Intra LEPROTL1 O95214 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 EDA Homo sapiens Q92838
Validated Y2H
32296183
Intra LEPROTL1 O95214 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra LEPROTL1 O95214 LMBR1 Homo sapiens Q8WVP7
Validated Y2H
32296183
Intra LEPROTL1 O95214 LMBR1 Homo sapiens Q8WVP7
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 LMBR1 Homo sapiens Q8WVP7
Y2H Array
32296183
Intra LEPROTL1 O95214 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra LEPROTL1 O95214 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra LEPROTL1 O95214 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra LEPROTL1 O95214 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra LEPROTL1 O95214 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra LEPROTL1 O95214 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra LEPROTL1 O95214 TMEM11 Homo sapiens P17152
Validated Y2H
32296183
Intra LEPROTL1 O95214 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
32296183
Intra LEPROTL1 O95214 SYNDIG1 Homo sapiens Q9H7V2
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 SYNDIG1 Homo sapiens Q9H7V2
Y2H Array
32296183
Intra LEPROTL1 O95214 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra LEPROTL1 O95214 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra LEPROTL1 O95214 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra LEPROTL1 O95214 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra LEPROTL1 O95214 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra LEPROTL1 O95214 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra LEPROTL1 O95214 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 GJA5 Homo sapiens P36382
Validated Y2H
32296183
Intra LEPROTL1 O95214 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra LEPROTL1 O95214 KLRG1 Homo sapiens Q96E93
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 KLRG1 Homo sapiens Q96E93
Validated Y2H
32296183
Intra LEPROTL1 O95214 KLRG1 Homo sapiens Q96E93
Y2H Array
32296183
Intra LEPROTL1 O95214 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra LEPROTL1 O95214 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra LEPROTL1 O95214 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra LEPROTL1 O95214 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra LEPROTL1 O95214 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra LEPROTL1 O95214 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra LEPROTL1 O95214 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra LEPROTL1 O95214 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra LEPROTL1 O95214 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rectal Benign Neoplasm

Neoplasm Of Rectum

Rectal Tumor

Rectum Neoplasm

Neoplasm Of The Rectum

Rectal Neoplasms

Primary Rectal Cancer

Rectal Ampulla Cancer

Cancer Of The Rectum

Carcinoma Of Rectum

Primary Malignant Neoplasm Of Rectum

Rectal Cancer

Rectal Carcinoma
Esophagus Adenocarcinoma

Esophageal Adenocarcinoma

Oesophageal Adenocarcinoma

Adenocarcinoma Of Esophagus

Adenocarcinoma Of The Esophagus
Rectum Adenocarcinoma

Rectal Adenocarcinoma

Adenocarcinoma Of Rectum
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07596 LEPROTL1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LEPROTL1 VGNC VGNC:30845
Rattus norvegicus LEPROTL1 RGD RGD:1307168
Macaca mulatta LEPROTL1 VGNC VGNC:74252
Felis catus LEPROTL1 VGNC VGNC:78521
Mus musculus LEPROTL1 MGD MGI:1915442
Canis familiaris LEPROTL1 VGNC VGNC:42640
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