1. Gene
  2. RNF5 - ring finger protein 5 Gene

RNF5 - ring finger protein 5 Gene

中文名称:无名指蛋白 5

种属: Homo sapiens

同用名: RMA1; RING5

基因 ID: 6048 | 基因类型: protein coding

关于 RNF5

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,178,405-32,180,793 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 185 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 45.9), small intestine (RPKM 33.9) and 25 other tissues.

功能概要

该基因编码的蛋白质包含一个无名指,这是一个已知参与蛋白质-蛋白质相互作用的基序。这种蛋白质是一种膜结合泛素连接酶。它可以通过靶向桩蛋白泛素化并改变桩蛋白在细胞质和细胞粘着斑中的分布和定位来调节细胞运动。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin Ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

RNF5 基因产物(1)

mRNA Protein Name
NM_006913.4 NP_008844.1 E3 ubiquitin-protein ligase RNF5
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12861019 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
24019521 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
19269966 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IMP
IMP: 通过突变表型推断
19269966 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
19285439 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
19269966 GOA
involved in protein catabolic process IMP
IMP: 通过突变表型推断
19285439 GOA
involved in ubiquitin-dependent protein catabolic process IGI
IGI: 通过遗传相互作用推断
24019521 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNF5 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (27 - 67)

  • 0
  • 100
  • 180 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF5

RING-type E3 ubiquitin transferase RNF5

RNF5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF5 Q99942 UBE2W Homo sapiens Q96FI0 25416956
种属内
RNF5 Q99942 UBE2W Homo sapiens Q96FI0 25416956
种属内
RNF5 Q99942 SLC38A7 Homo sapiens Q9NVC3 32296183
种属内
RNF5 Q99942 SLC38A7 Homo sapiens Q9NVC3 25416956
种属内
RNF5 Q99942 TMEM242 Homo sapiens Q9NWH2 25416956
种属内
RNF5 Q99942 ORMDL1 Homo sapiens Q9P0S3 32296183
种属内
RNF5 Q99942 UBE2E2 Homo sapiens Q96LR5 25416956
种属内
RNF5 Q99942 UBE2E2 Homo sapiens Q96LR5 25416956
种属内
RNF5 Q99942 UBE2E2 Homo sapiens Q96LR5 25416956
种属内
RNF5 Q99942 RNF185 Homo sapiens Q96GF1 25416956
种属内
RNF5 Q99942 RNF185 Homo sapiens Q96GF1 33961781
种属内
RNF5 Q99942 RNF185 Homo sapiens Q96GF1 25416956
种属内
RNF5 Q99942 RNF185 Homo sapiens Q96GF1 25416956
种属内
RNF5 Q99942 UBE2D2 Homo sapiens P62837
Y2H
14667819
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077 25416956
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077
Y2H
19549727
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077 25416956
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077 32296183
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077
Y2H
14667819
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077 25416956
种属内
RNF5 Q99942 UBE2D3 Homo sapiens P61077 19549727
种属内
RNF5 Q99942 UBE2E3 Homo sapiens Q969T4
Y2H
14667819
种属内
RNF5 Q99942 UBE2E3 Homo sapiens Q969T4 31515488
种属内
RNF5 Q99942 UBE2E3 Homo sapiens Q969T4 25416956
种属内
RNF5 Q99942 UBE2E3 Homo sapiens Q969T4 19549727
种属内
RNF5 Q99942 ABHD16A Homo sapiens O95870 25416956
种属内
RNF5 Q99942 ABHD16A Homo sapiens O95870 25416956
种属内
RNF5 Q99942 CFTR Homo sapiens P13569 16901789
种属内
RNF5 Q99942 SLC1A5 Homo sapiens Q15758 25759021
种属内
RNF5 Q99942 SLC1A5 Homo sapiens Q15758 25759021
种属内
RNF5 Q99942 UBE2K Homo sapiens P61086 32814053
种属内
RNF5 Q99942 UBE2K Homo sapiens P61086 25416956
种属内
RNF5 Q99942 UBE2K Homo sapiens P61086 32814053
种属内
RNF5 Q99942 UBE2K Homo sapiens P61086 32814053
种属内
RNF5 Q99942 UBE2K Homo sapiens P61086 25416956
种属内
RNF5 Q99942 PXN Homo sapiens P49023 12861019
种属内
RNF5 Q99942 PXN Homo sapiens P49023 12861019
种属内
RNF5 Q99942 RABAC1 Homo sapiens Q9UI14 32296183
种属内
RNF5 Q99942 UBE2W Homo sapiens Q96B02 25416956
种属内
RNF5 Q99942 UBE2W Homo sapiens Q96B02 19549727
种属内
RNF5 Q99942 SLC38A2 Homo sapiens Q96QD8 25759021
种属内
RNF5 Q99942 SLC38A2 Homo sapiens Q96QD8 25759021
种属内
RNF5 Q99942 UBE2D1 Homo sapiens P51668 19549727
种属内
RNF5 Q99942 UBE2D1 Homo sapiens P51668 25416956
种属内
RNF5 Q99942 UBE2D1 Homo sapiens P51668
Y2H
19549727
种属内
RNF5 Q99942 UBE2D1 Homo sapiens P51668 25416956
种属内
RNF5 Q99942 SLC1A1 Homo sapiens P43005 25416956
种属内
RNF5 Q99942 SLC1A1 Homo sapiens P43005 25416956
种属内
RNF5 Q99942 UBE2D4 Homo sapiens Q9Y2X8 32296183
种属内
RNF5 Q99942 UBE2D4 Homo sapiens Q9Y2X8 25416956
种属内
RNF5 Q99942 UBTD1 Homo sapiens Q9HAC8 32296183
种属内
RNF5 Q99942 OPTN Homo sapiens Q96CV9 32814053
种属内
RNF5 Q99942 OPTN Homo sapiens Q96CV9 32814053
种属内
RNF5 Q99942 OPTN Homo sapiens Q96CV9 32814053
种属内
RNF5 Q99942 YIPF2 Homo sapiens Q9BWQ6 25416956
种属内
RNF5 Q99942 YIPF2 Homo sapiens Q9BWQ6 32296183
种属内
RNF5 Q99942 YIPF2 Homo sapiens Q9BWQ6 25416956
种属内
RNF5 Q99942 YIPF4 Homo sapiens Q9BSR8 32296183
种属内
RNF5 Q99942 YIPF1 Homo sapiens Q9Y548 32296183
种属内
RNF5 Q99942 INSIG2 Homo sapiens Q9Y5U4 32296183
种属内
RNF5 Q99942 INSIG2 Homo sapiens Q9Y5U4 25416956
种属内
RNF5 Q99942 CYB561 Homo sapiens P49447 25416956
种属内
RNF5 Q99942 CYB561 Homo sapiens P49447 25416956
种属内
RNF5 Q99942 CYB561 Homo sapiens P49447 25416956
种属内
RNF5 Q99942 SEC22A Homo sapiens Q96IW7 25416956
种属内
RNF5 Q99942 SEC22A Homo sapiens Q96IW7 25416956
种属内
RNF5 Q99942 RHBDD1 Homo sapiens Q8TEB9 33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Inflammatory Bowel Disease 7

IBD7

Herpes Simplex Virus Keratitis

Dendritic Keratitis

Keratitis, Dendritic

Keratitis, Herpetic

Phosphoglycerate Dehydrogenase Deficiency

Phgdh Deficiency

3-Phosphoglycerate Dehydrogenase Deficiency

PHGDHD

3-Pgdh Deficiency

3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form

Phgdh Deficiency, Infantile/Juvenile Form

Deficiency, Phosphoglycerate Dehydrogenase

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RNF5 VGNC VGNC:76706
Bos taurus RNF5 VGNC VGNC:34070
Felis catus RNF5 VGNC VGNC:64705
Canis familiaris RNF5 VGNC VGNC:45673
Rattus norvegicus RNF5 RGD RGD:1588458
Mus musculus RNF5 MGD MGI:1860076
Others RNF5 NCBI