2. Gene
  3. RNF185 - ring finger protein 185 Gene

RNF185 - ring finger protein 185 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 185

种属: Homo sapiens

基因 ID: 91445 | 基因类型: protein coding

关于 RNF185

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,160,182-31,207,019 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 37.5), prostate (RPKM 19.7) and 25 other tissues.

功能概要

启用泛素结合活动；泛素蛋白连接酶活性；和泛素样蛋白结合酶结合活性。参与 ERAD 通路的正调控；蛋白质自身泛素化；和泛素依赖性 ERAD 通路。位于内质网。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin binding activity; ubiquitin protein Ligase activity; and ubiquitin-like protein conjugating Enzyme binding activity. Involved in positive regulation of ERAD pathway; protein autoubiquitination; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

RNF185 基因产物(2)

mRNA Protein Name
NM_001135825.2 NP_001129297.1 E3 ubiquitin-protein ligase RNF185 isoform 2
NM_152267.4 NP_689480.2 E3 ubiquitin-protein ligase RNF185 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19549727 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
24019521 GOA
enables ubiquitin binding IDA
IDA: 通过直接分析推断
27485036 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
24019521 GOA
enables ubiquitin-like protein conjugating enzyme binding IPI
IPI: 通过物理相互作用推断
24019521 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERAD pathway IGI
IGI: 通过遗传相互作用推断
24019521 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
28273161 GOA
involved in positive regulation of ERAD pathway IMP
IMP: 通过突变表型推断
27485036 GOA
involved in positive regulation of innate immune response IDA
IDA: 通过直接分析推断
28273161 GOA
involved in positive regulation of type I interferon-mediated signaling pathway IDA
IDA: 通过直接分析推断
28273161 GOA
involved in protein K27-linked ubiquitination IDA
IDA: 通过直接分析推断
28273161 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
24019521 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
24019521 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24019521 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF185 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (39 - 79)

  • 0
  • 100
  • 192 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF185

BSK65-MONO1

RNF185 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RNF185 Q96GF1 TMBIM6 Homo sapiens P55061
Anti Tag CoIP
28514442
Intra RNF185 Q96GF1 TMBIM6 Homo sapiens P55061
Anti Tag CoIP
33961781
Intra RNF185 Q96GF1 UBE2E2 Homo sapiens Q96LR5
Y2H Array
19549727
Intra RNF185 Q96GF1 UBE2E2 Homo sapiens Q96LR5
Validated Y2H
32296183
Intra RNF185 Q96GF1 CMTM5 Homo sapiens Q96DZ9
Validated Y2H
25416956
Intra RNF185 Q96GF1 ARL6IP5 Homo sapiens O75915
Validated Y2H
25416956
Intra RNF185 Q96GF1 ARL6IP5 Homo sapiens O75915
Y2H Prey Pooling
25416956
Intra RNF185 Q96GF1 ARL6IP5 Homo sapiens O75915
Y2H Array
25416956
Intra RNF185 Q96GF1 UBE2D2 Homo sapiens P62837
Y2H Array
19549727
Intra RNF185 Q96GF1 UBE2E3 Homo sapiens Q969T4
Y2H Array
25416956
Intra RNF185 Q96GF1 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra RNF185 Q96GF1 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra RNF185 Q96GF1 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra RNF185 Q96GF1 UBE2D4 Homo sapiens Q9Y2X8
Validated Y2H
32296183
Intra RNF185 Q96GF1 YIPF2 Homo sapiens Q9BWQ6
Y2H Prey Pooling
25416956
Intra RNF185 Q96GF1 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra RNF185 Q96GF1 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
25416956
Intra RNF185 Q96GF1 YIPF4 Homo sapiens Q9BSR8
Y2H Prey Pooling
25416956
Intra RNF185 Q96GF1 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12069 RNF185 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RNF185 VGNC VGNC:64686
Rattus norvegicus RNF185 RGD RGD:1564777
Mus musculus RNF185 MGD MGI:1922078
Macaca mulatta RNF185 VGNC VGNC:76841
Bos taurus RNF185 VGNC VGNC:34042
Canis familiaris RNF185 VGNC VGNC:45648
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