1. Gene
  2. TMBIM6 - transmembrane BAX inhibitor motif containing 6 Gene

TMBIM6 - transmembrane BAX inhibitor motif containing 6 Gene

中文名称:含跨膜 BAX 抑制剂基序 6

种属: Homo sapiens

同用名: BI-1; TEGT; BAXI1

基因 ID: 7009 | 基因类型: protein coding

关于 TMBIM6

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,741,557-49,764,934 (from NCBI)

This gene has 28 transcripts (splice variants), 251 orthologues and 5 paralogues. Ubiquitous expression in kidney (RPKM 392.9), liver (RPKM 352.7) and 25 other tissues.

功能概要

启用内切核糖核酸酶抑制剂活性和泛素蛋白连接酶结合活性。参与多个过程,包括 RNA 代谢过程的负调控;内在凋亡信号通路的负调节;和对 L-谷氨酸的反应。在钙离子转运到胞质溶胶的负调节上游或负调节内起作用。位于内质网膜和线粒体膜上。宫颈鳞状细胞癌和前列腺癌的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Enables endoribonuclease inhibitor activity and ubiquitin protein Ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process; negative regulation of intrinsic apoptotic signaling pathway; and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM6 基因产物(2)

mRNA Protein Name
NM_001098576.2 NP_001092046.1 bax inhibitor 1 isoform 2
NM_003217.3 NP_003208.2 bax inhibitor 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endoribonuclease inhibitor activity IDA
IDA: 通过直接分析推断
19328063 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
19328063 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9660918 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
21068390 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9660918 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
19328063 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
9660918 GOA
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
9660918 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMBIM6 蛋白结构

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (24 - 225)

  • 0
  • 100
  • 200
  • 237 a.a.
蛋白主名 其他名称

bax inhibitor 1

testis enhanced gene transcript

TMBIM6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMBIM6 P55061 CD300LG Homo sapiens Q6UXG3
Validated Y2H
32296183
种属内
TMBIM6 P55061 CD300LG Homo sapiens Q6UXG3
Y2H Array
32296183
种属内
TMBIM6 P55061 CD300LG Homo sapiens Q6UXG3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 JSRP1 Homo sapiens Q96MG2
Validated Y2H
32296183
种属内
TMBIM6 P55061 JSRP1 Homo sapiens Q96MG2
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 JSRP1 Homo sapiens Q96MG2
Y2H Array
32296183
种属内
TMBIM6 P55061 REEP2 Homo sapiens Q9BRK0
Validated Y2H
32296183
种属内
TMBIM6 P55061 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
种属内
TMBIM6 P55061 TMUB1 Homo sapiens Q9BVT8
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 TMUB1 Homo sapiens Q9BVT8
Validated Y2H
32296183
种属内
TMBIM6 P55061 TMUB1 Homo sapiens Q9BVT8
Y2H Array
32296183
种属内
TMBIM6 P55061 GPHB5 Homo sapiens Q86YW7
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GPHB5 Homo sapiens Q86YW7
Validated Y2H
32296183
种属内
TMBIM6 P55061 GPHB5 Homo sapiens Q86YW7
Y2H Array
32296183
种属内
TMBIM6 P55061 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
种属内
TMBIM6 P55061 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
种属内
TMBIM6 P55061 GPR151 Homo sapiens Q8TDV0
Validated Y2H
32296183
种属内
TMBIM6 P55061 GPR151 Homo sapiens Q8TDV0
Y2H Array
32296183
种属内
TMBIM6 P55061 GPR151 Homo sapiens Q8TDV0
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ATP13A1 Homo sapiens Q9HD20-3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ATP13A1 Homo sapiens Q9HD20-3
Y2H Array
32296183
种属内
TMBIM6 P55061 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
种属内
TMBIM6 P55061 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
种属内
TMBIM6 P55061 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
种属内
TMBIM6 P55061 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 PIANP Homo sapiens Q8IYJ0
Y2H Array
32296183
种属内
TMBIM6 P55061 PIANP Homo sapiens Q8IYJ0
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 PIANP Homo sapiens Q8IYJ0
Validated Y2H
32296183
种属内
TMBIM6 P55061 KCNA10 Homo sapiens Q16322
Validated Y2H
32296183
种属内
TMBIM6 P55061 KCNA10 Homo sapiens Q16322
Y2H Array
32296183
种属内
TMBIM6 P55061 KCNA10 Homo sapiens Q16322
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
种属内
TMBIM6 P55061 ODF4 Homo sapiens Q2M2E3
Validated Y2H
32296183
种属内
TMBIM6 P55061 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 MS4A3 Homo sapiens Q96HJ5
Validated Y2H
32296183
种属内
TMBIM6 P55061 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
种属内
TMBIM6 P55061 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
种属内
TMBIM6 P55061 PI16 Homo sapiens Q6UXB8
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 PI16 Homo sapiens Q6UXB8
Validated Y2H
32296183
种属内
TMBIM6 P55061 PI16 Homo sapiens Q6UXB8
Y2H Array
32296183
种属内
TMBIM6 P55061 HJV Homo sapiens Q6ZVN8-3
Validated Y2H
32296183
种属内
TMBIM6 P55061 HJV Homo sapiens Q6ZVN8-3
Y2H Array
32296183
种属内
TMBIM6 P55061 HJV Homo sapiens Q6ZVN8-3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 KCNC1 Homo sapiens P48547
Y2H Array
32296183
种属内
TMBIM6 P55061 KCNC1 Homo sapiens P48547
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GJB4 Homo sapiens Q9NTQ9
Validated Y2H
32296183
种属内
TMBIM6 P55061 GJB4 Homo sapiens Q9NTQ9
Y2H Array
32296183
种属内
TMBIM6 P55061 GJB4 Homo sapiens Q9NTQ9
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SLC12A7 Homo sapiens Q9Y666-2
Validated Y2H
32296183
种属内
TMBIM6 P55061 SLC12A7 Homo sapiens Q9Y666-2
Y2H Array
32296183
种属内
TMBIM6 P55061 SLC12A7 Homo sapiens Q9Y666-2
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 UGT2B11 Homo sapiens O75310
Y2H Array
32296183
种属内
TMBIM6 P55061 UGT2B11 Homo sapiens O75310
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 RHBDL2 Homo sapiens Q9NX52-3
Validated Y2H
32296183
种属内
TMBIM6 P55061 RHBDL2 Homo sapiens Q9NX52-3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 RHBDL2 Homo sapiens Q9NX52-3
Y2H Array
32296183
种属内
TMBIM6 P55061 FGFBP2 Homo sapiens Q9BYJ0
Validated Y2H
32296183
种属内
TMBIM6 P55061 FGFBP2 Homo sapiens Q9BYJ0
Y2H Array
32296183
种属内
TMBIM6 P55061 FGFBP2 Homo sapiens Q9BYJ0
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 STEAP1B Homo sapiens Q6NZ63
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 STEAP1B Homo sapiens Q6NZ63
Validated Y2H
32296183
种属内
TMBIM6 P55061 STEAP1B Homo sapiens Q6NZ63
Y2H Array
32296183
种属内
TMBIM6 P55061 SLAMF6 Homo sapiens Q96DU3
Validated Y2H
32296183
种属内
TMBIM6 P55061 SLAMF6 Homo sapiens Q96DU3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SLAMF6 Homo sapiens Q96DU3
Y2H Array
32296183
种属内
TMBIM6 P55061 TREML1 Homo sapiens Q86YW5
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 TREML1 Homo sapiens Q86YW5
Y2H Array
32296183
种属内
TMBIM6 P55061 TREML1 Homo sapiens Q86YW5
Validated Y2H
32296183
种属内
TMBIM6 P55061 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
种属内
TMBIM6 P55061 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
种属内
TMBIM6 P55061 ENPP4 Homo sapiens Q9Y6X5
Validated Y2H
32296183
种属内
TMBIM6 P55061 ENPP4 Homo sapiens Q9Y6X5
Y2H Array
32296183
种属内
TMBIM6 P55061 ENPP4 Homo sapiens Q9Y6X5
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GJA8 Homo sapiens P48165
Y2H Array
32296183
种属内
TMBIM6 P55061 IER3 Homo sapiens P46695
Y2H Array
32296183
种属内
TMBIM6 P55061 IER3 Homo sapiens P46695
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ADIPOR2 Homo sapiens Q86V24
Validated Y2H
32296183
种属内
TMBIM6 P55061 ADIPOR2 Homo sapiens Q86V24
Y2H Array
32296183
种属内
TMBIM6 P55061 ADIPOR2 Homo sapiens Q86V24
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 CLDN22 Homo sapiens Q8N7P3
Validated Y2H
32296183
种属内
TMBIM6 P55061 CLDN22 Homo sapiens Q8N7P3
Y2H Array
32296183
种属内
TMBIM6 P55061 CLDN22 Homo sapiens Q8N7P3
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GPR42 Homo sapiens O15529
Y2H Array
32296183
种属内
TMBIM6 P55061 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
TMBIM6 P55061 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
种属内
TMBIM6 P55061 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 TEX29 Homo sapiens Q8N6K0
Validated Y2H
32296183
种属内
TMBIM6 P55061 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
种属内
TMBIM6 P55061 SYT9 Homo sapiens Q86SS6
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SYT9 Homo sapiens Q86SS6
Validated Y2H
32296183
种属内
TMBIM6 P55061 SYT9 Homo sapiens Q86SS6
Y2H Array
32296183
种属内
TMBIM6 P55061 COBLL1 Homo sapiens A0A7P0TAB9
Y2H Array
32296183
种属内
TMBIM6 P55061 RNF185 Homo sapiens Q96GF1
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 RNF185 Homo sapiens Q96GF1
Validated Y2H
32296183
种属内
TMBIM6 P55061 RNF185 Homo sapiens Q96GF1
Y2H Array
32296183
种属内
TMBIM6 P55061 CD99L2 Homo sapiens Q8TCZ2
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 CD99L2 Homo sapiens Q8TCZ2
Validated Y2H
32296183
种属内
TMBIM6 P55061 CD99L2 Homo sapiens Q8TCZ2
Y2H Array
32296183
种属内
TMBIM6 P55061 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
种属内
TMBIM6 P55061 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
种属内
TMBIM6 P55061 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 HERPUD2 Homo sapiens Q9BSE4
Validated Y2H
32296183
种属内
TMBIM6 P55061 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
种属内
TMBIM6 P55061 LRRC59 Homo sapiens Q96AG4
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 LRRC59 Homo sapiens Q96AG4
Y2H Array
32296183
种属内
TMBIM6 P55061 LRRC59 Homo sapiens Q96AG4
Validated Y2H
32296183
种属内
TMBIM6 P55061 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
种属内
TMBIM6 P55061 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
种属内
TMBIM6 P55061 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 CDC7 Homo sapiens O00311
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 CDC7 Homo sapiens O00311
Y2H Array
32296183
种属内
TMBIM6 P55061 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
种属内
TMBIM6 P55061 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
种属内
TMBIM6 P55061 GZMK Homo sapiens P49863
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GZMK Homo sapiens P49863
Y2H Array
32296183
种属内
TMBIM6 P55061 EBP Homo sapiens Q15125
Validated Y2H
32296183
种属内
TMBIM6 P55061 EBP Homo sapiens Q15125
Y2H Array
32296183
种属内
TMBIM6 P55061 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 PVR Homo sapiens P15151
Y2H Array
32296183
种属内
TMBIM6 P55061 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
种属内
TMBIM6 P55061 ESAM Homo sapiens Q96AP7
Validated Y2H
32296183
种属内
TMBIM6 P55061 ESAM Homo sapiens Q96AP7
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ESAM Homo sapiens Q96AP7
Y2H Array
32296183
种属内
TMBIM6 P55061 TNFRSF17 Homo sapiens Q02223
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 TNFRSF17 Homo sapiens Q02223
Validated Y2H
32296183
种属内
TMBIM6 P55061 TNFRSF17 Homo sapiens Q02223
Y2H Array
32296183
种属内
TMBIM6 P55061 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
种属内
TMBIM6 P55061 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 MMGT1 Homo sapiens Q8N4V1
Validated Y2H
32296183
种属内
TMBIM6 P55061 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
种属内
TMBIM6 P55061 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
种属内
TMBIM6 P55061 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
种属内
TMBIM6 P55061 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
TMBIM6 P55061 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SIT1 Homo sapiens Q9Y3P8
Y2H Array
32296183
种属内
TMBIM6 P55061 SIT1 Homo sapiens Q9Y3P8
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 SIT1 Homo sapiens Q9Y3P8
Validated Y2H
32296183
种属内
TMBIM6 P55061 GYPA Homo sapiens P02724
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GYPA Homo sapiens P02724
Y2H Array
32296183
种属内
TMBIM6 P55061 SLC41A3 Homo sapiens Q96GZ6
Validated Y2H
32296183
种属内
TMBIM6 P55061 SLC41A3 Homo sapiens Q96GZ6
Y2H Array
32296183
种属内
TMBIM6 P55061 SLC41A3 Homo sapiens Q96GZ6
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 GJA5 Homo sapiens P36382
Y2H Array
32296183
种属内
TMBIM6 P55061 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 CD79A Homo sapiens P11912
Y2H Array
32296183
种属内
TMBIM6 P55061 SOAT2 Homo sapiens O75908
Y2H Array
32296183
种属内
TMBIM6 P55061 SOAT2 Homo sapiens O75908
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ERP29 Homo sapiens P30040
Y2H Prey Pooling
32296183
种属内
TMBIM6 P55061 ERP29 Homo sapiens P30040
Y2H Array
32296183
种属内
TMBIM6 P55061 HTR2C Homo sapiens P28335
Y2H Array
32296183
种属内
TMBIM6 P55061 HTR2C Homo sapiens P28335
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Congestive Splenomegaly
Hypoglycemia, Leucine-Induced

Leucine-Sensitive Hypoglycemia Of Infancy

Leucine-Induced Hypoglycemia

LIH

Hypoglycemia Of Infancy, Leucine-Sensitive

Familial Infantile Hypoglycemia Precipitated By Leucine

Hypoglycemia Leucine Induced

Hypoglycemia Leucine-Induced

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TMBIM6 VGNC VGNC:66233
Canis familiaris TMBIM6 VGNC VGNC:47419
Macaca mulatta TMBIM6 VGNC VGNC:107118
Bos taurus TMBIM6 VGNC VGNC:35916
Rattus norvegicus TMBIM6 RGD RGD:3842
Mus musculus TMBIM6 MGD MGI:99682