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  2. HTR2C - 5-hydroxytryptamine receptor 2C Gene

HTR2C - 5-hydroxytryptamine receptor 2C Gene

中文名称:5-羟色胺受体 2C

种属: Homo sapiens

同用名: HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C

基因 ID: 3358 | 基因类型: protein coding

关于 HTR2C

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:114,584,086-114,910,061 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and 8 paralogues. Restricted expression toward brain (RPKM 1.3).

功能概要

该基因编码一个七次跨膜的 G 蛋白偶联受体。编码的蛋白质通过神经递质血清素响应信号。该基因的 mRNA 受到多个 RNA 编辑事件的影响,其中基因组编码的腺苷残基被转化为肌苷。预计 RNA 编辑会改变第二个细胞内环的结构,从而产生与 G 蛋白相互作用能力降低的替代蛋白质形式。已在患有抑郁症的自杀受害者中检测到该基因的 RNA 编辑异常。此外,该基因的启动子和 5' 非编码区和编码区的自然变异可能与精神疾病和行为障碍具有统计学显着关联。选择性剪接会产生多种不同的转录本变体。[RefSeq 提供,2015 年 1 月]

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

HTR2C 基因产物(3)

mRNA Protein Name
NM_000868.4 NP_000859.2 5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256760.3 NP_001243689.2 5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256761.3 NP_001243690.2 5-hydroxytryptamine receptor 2C isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IDA
IDA: 通过直接分析推断
19057895 GOA
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
7582481 GOA
enables Gq/11-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
18703043 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15518545 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14988405 GOA
enables serotonin binding IDA
IDA: 通过直接分析推断
7582481 GOA
enables serotonin receptor activity IDA
IDA: 通过直接分析推断
29398112 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of G protein-coupled serotonin receptor complex IDA
IDA: 通过直接分析推断
12970106 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12970106 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
18703043 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HTR2C 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (70 - 368)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

HTR2C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HTR2C P28335 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra HTR2C P28335 MTNR1B Homo sapiens P49286
BRET
25770211
Intra HTR2C P28335 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra HTR2C P28335 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra HTR2C P28335 TMEM147 Homo sapiens Q9BVK8
Anti Tag CoIP
33961781
Intra HTR2C P28335 TMEM147 Homo sapiens Q9BVK8
Anti Tag CoIP
28514442
Intra HTR2C P28335 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra HTR2C P28335 HTR2A Homo sapiens P28223
PLA
30157263
Intra HTR2C P28335 HTR2A Homo sapiens P28223
BRET
30157263
Intra HTR2C P28335 HTR2B Homo sapiens P41595
BRET
28258217
Intra HTR2C P28335 HTR2B Homo sapiens P41595
Anti Tag CoIP
28258217
Intra HTR2C P28335 HTR2C Homo sapiens P28335
Anti Tag CoIP
28258217
Intra HTR2C P28335 HTR2C Homo sapiens P28335
BRET
25770211
Intra HTR2C P28335 HTR2C Homo sapiens P28335
FRET
16195233
Intra HTR2C P28335 HTR2C Homo sapiens P28335
Crosslink
16195233
Intra HTR2C P28335 HTR2C Homo sapiens P28335
FRET
15518545
Intra HTR2C P28335 HTR2C Homo sapiens P28335
BRET
15518545
Intra HTR2C P28335 HTR2C Homo sapiens P28335
Crosslink
15518545
Intra HTR2C P28335 HTR2C Homo sapiens P28335
BRET
28258217
Intra HTR2C P28335 HTR2C Homo sapiens P28335
Confocal
16195233
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis

Premature Ejaculation
Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Personality Disorder

Personality Disorders

Character Disorder

Personality

Specific Personality Disorders

Enduring Personality Change After Psychiatric Illness

Borderline Personality Disorder
Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Migraine With Aura

Classic Migraine

Migraine With Typical Aura

Migraine Accompagnée

Complicated Migraine

Classical Migraine

Acute Migraine With Aura

Hyperprolactinemia

Chiari-Frommel Syndrome

Hyperprolactinaemia

Familial Hyperprolactinemia

HPRL

Pregnancy-Related A-G Syndrome

Familial Isolated Prolactin Receptor Deficiency

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Bulimia Nervosa

Bulimia

Bulimia Nervosa, Susceptibility To

Binge Eating Disorder

BULN

Bn

Hyperorexia Nervosa

Bulimia Nervosa 2

BULN2

Susceptibility To Bulimia Nervosa

Bulimia Nervosa, Susceptibility To, Type 2

Bn - [Bulimia Nervosa]

Bulimia Nos

Bulimic

Bingeing

Binge Overeating

Bouts Of Overeating

Episodes Of Overeating

Bipolar I Disorder

Manic Depression Nos

Manic-Depressive Illness

Bipolar Disorder Nos

Generalized Anxiety Disorder

Anxiety Generalized

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To

ANON

Anorexia Nervosa, Susceptibility To, 1

An

Anorexia Nervosa 1

An - [Anorexia Nervosa]

Psychosexual Disorder

Psychosexual Disorders

Delusional Disorder

Persistent Delusional Disorders

Delusional Perception

Induced Delusional Disorder

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Sexual Health Disorder

Sexual Health

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Sleep Apnea

Sleep Apnea Syndromes

High Pressure Neurological Syndrome
Lingual-Facial-Buccal Dyskinesia

Orofacial Dyskinesia

Oro-Facial Dyskinesia

Dyskinesias

Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Hypochondriasis

Hypochondriacal Disorder

Hypochondria

Hypochondriacal Neurosis

Illness Anxiety Disorder

Health Anxiety Disorder

Hypochondriacal Reaction

Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Neurotic Disorder

Neurosis

Reactive Depression

Adjustment Disorders

Neurotic Disorders

Depressive Neurosis

Neurotic Depression

Neurotic Depression Reactive Type

Neurotic Depressive State

Psychoneurosis

Depressive Disorder

Depression, Neurotic

Mental Depression

Depression

Depressive Disorder

Paranoid Schizophrenia

Chronic Paranoid Schizophrenia

Paranoid Type Schizophrenia

Paranoid Type Schizophrenia Subchronic State

Paraphrenia - Late

Paraphrenic Schizophrenia

Schizophrenia, Paranoid

Intermittent Explosive Disorder

Explosive Personality Disorder

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Dysthymic Disorder

Dysthymia

Chronic Depressive Disorder

Chronic Depression

Depressive Personality

Depressive Personality Disorder

Persistent Depressive Disorder

Persistent Depression

Drug Psychosis

Drug-Induced Psychosis

Drug-Induced Psychotic Disorder

Psychoses, Substance-Induced

Psychoses, Drug

Drug-Induced Mental Disorder
Oppositional Defiant Disorder

Disorder

Oppositional Defiance

Behavioural Disorder

Oppositional Defiance

Disruptive Mood Dysregulation Disorder

Substance-Induced Psychosis
Endogenous Depression

Clinical Depression

Unipolar Depression

Depressive Disorder

Bruxism

Sleep Bruxism

Sleep-Related Bruxism

Bruxism - Teeth Grinding

Grinding Teeth

Sleep Related Bruxism

Teeth Grinding

Sleep Related Teeth Grinding

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Disease Of Mental Health

Mental Health

Mental Disorders

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HTR2C RGD RGD:2848
Canis familiaris HTR2C VGNC VGNC:41828
Macaca mulatta HTR2C VGNC VGNC:73541
Mus musculus HTR2C MGD MGI:96281