HTR2B - 5-hydroxytryptamine receptor 2B Gene

中文名称：5-羟色胺受体 2B

种属: Homo sapiens

同用名: 5-HT2B; 5-HT-2B; 5-HT(2B)

基因 ID: 3357 | 基因类型: protein coding

关于 HTR2B

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,108,230-231,125,042 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 8 paralogues. Biased expression in endometrium (RPKM 10.3), adrenal (RPKM 7.1) and 8 other tissues.

功能概要

该基因编码属于 G 蛋白偶联受体 1 家族的 5-羟色胺 (5-羟色胺) 的几种不同受体之一。血清素是一种生物激素，具有神经递质、激素和有丝分裂原的作用。血清素受体介导血清素的许多中枢和外周生理功能，包括心血管功能和冲动行为的调节。对阻断该蛋白表达的次要等位基因 (谷氨酰胺终止取代，命名为 Q20*) 进行的基于群体和家族的分析，以及在小鼠中进行的基因敲除研究，表明该基因在冲动性中发挥作用。然而，也可能涉及其他因素，例如睾丸激素水平升高。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2016 年 3 月]

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, Other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

HTR2B 基因产物(2)

mRNA	Protein	Name
NM_000867.5	NP_000858.3	5-hydroxytryptamine receptor 2B isoform 1
NM_001320758.2	NP_001307687.1	5-hydroxytryptamine receptor 2B isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G protein-coupled serotonin receptor activity	IDA IDA: 通过直接分析推断	7582481	GOA
enables G protein-coupled serotonin receptor activity	IMP IMP: 通过突变表型推断	15625277	GOA
enables G-protein alpha-subunit binding	IMP IMP: 通过突变表型推断	15625277	GOA
enables Gq/11-coupled serotonin receptor activity	IDA IDA: 通过直接分析推断	18703043	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28258217	GOA
enables serotonin binding	IDA IDA: 通过直接分析推断	7582481	GOA
enables serotonin receptor activity	IDA IDA: 通过直接分析推断	30127358	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	19308295	GOA
involved in G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	15625277	GOA
involved in G protein-coupled serotonin receptor signaling pathway	IDA IDA: 通过直接分析推断	7926008	GOA
involved in G protein-coupled serotonin receptor signaling pathway	IMP IMP: 通过突变表型推断	18703043	GOA
involved in cGMP-mediated signaling	IDA IDA: 通过直接分析推断	12970106	GOA
involved in calcium-mediated signaling	IMP IMP: 通过突变表型推断	8882600	GOA
involved in intestine smooth muscle contraction	IMP IMP: 通过突变表型推断	7599919	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	19057895	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: 通过直接分析推断	12970106	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IMP IMP: 通过突变表型推断	20099302	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	19057895	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: 通过表达模式推断	12761501	GOA
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	15625277	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	15925089	GOA
involved in positive regulation of cytokine production	IDA IDA: 通过直接分析推断	19023134	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: 通过突变表型推断	19308295	GOA
involved in positive regulation of phosphatidylinositol biosynthetic process	IDA IDA: 通过直接分析推断	19057895	GOA
involved in regulation of behavior	IMP IMP: 通过突变表型推断	21179162	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: 通过直接分析推断	15862800	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: 通过突变表型推断	8882600	GOA
involved in response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	15862800	GOA
involved in vasoconstriction	IMP IMP: 通过突变表型推断	15625277	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of G protein-coupled serotonin receptor complex	IDA IDA: 通过直接分析推断	7926008	GOA
part of G protein-coupled serotonin receptor complex	IMP IMP: 通过突变表型推断	15625277	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	15925089	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	7926008	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HTR2B 蛋白结构

7tm_1

0
100
200
300
400
481 a.a.

蛋白主名

其他名称

5-hydroxytryptamine receptor 2B

5-HT 2B receptor

HTR2B 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HTR2B	P41595	HTR2A	Homo sapiens	P28223	BRET	28258217
种属内	HTR2B	P41595	HTR2C	Homo sapiens	P28335	BRET	28258217

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Chronic Pulmonary Heart Disease

Intermittent Explosive Disorder

Explosive Personality Disorder

Pulmonary Valve Insufficiency

Pulmonary Regurgitation	Pulmonary Incompetence
Pulmonary Incompetence, Non-Rheumatic	Pulmonary Insufficiency Following Trauma And Surgery
Pulmonary Regurg.	Pulmonic Insufficiency
Pulmonic Valve Regurgitation	Pulmonary Valve Incompetence
Pulmonary Valve Incompetency	Pulmonary Valvular Insufficiency
Pulmonary Valvular Regurgitation	Pulmonary Valvular Incompetency
Pulmonary Valve Incompetence Nos	Annular Incompetency Pulmonary Valve
Incompetent Pulmonary Valve	Graham Steell Murmur
Pulmonary Valvular Incompetence

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-169229	GM-60186	Inhibitor	/	否
HY-RS06468	HTR2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HTR2B	RGD	RGD:61801
Bos taurus	HTR2B	VGNC	VGNC:29997
Macaca mulatta	HTR2B	VGNC	VGNC:73540
Felis catus	HTR2B	VGNC	VGNC:67672
Canis familiaris	HTR2B	VGNC	VGNC:41827
Mus musculus	HTR2B	MGD	MGI:109323

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HTR2B - 5-hydroxytryptamine receptor 2B Gene

关于 HTR2B

功能概要

HTR2B 基因产物(2)

HTR2B 蛋白结构

HTR2B 蛋白互作信息

关联疾病

直系同源

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HTR2B - 5-hydroxytryptamine receptor 2B Gene

关于 HTR2B

功能概要

HTR2B 基因产物(2)

HTR2B 蛋白结构

HTR2B 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z