2. Gene
  3. MTNR1B - melatonin receptor 1B Gene

MTNR1B - melatonin receptor 1B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：褪黑激素受体 1B

种属: Homo sapiens

同用名: MT2; FGQTL2; MEL-1B-R

基因 ID: 4544 | 基因类型: protein coding

关于 MTNR1B

Cytogenetic location: 11q14.3 Genomic coordinates (GRCh38): 11:92,969,651-92,984,960 (from NCBI)

This gene has 3 transcripts (splice variants), 106 orthologues, 33 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

该基因编码褪黑激素受体的两种高亲和力形式之一，褪黑激素是松果体分泌的主要激素。该基因产物是一种完整的膜蛋白，是一种 G 蛋白偶联的 7 次跨膜受体。它主要存在于视网膜和大脑中，尽管这种检测需要 RT-PCR。它被认为参与视网膜中的光依赖性功能，并可能参与褪黑激素的神经生物学效应。[RefSeq 提供，2008 年 7 月]

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1B 基因产物(3)

mRNA Protein Name
XM_017017777.2 XP_016873266.1 melatonin receptor type 1B isoform X1
NM_005959.5 NP_005950.1 melatonin receptor type 1B
XM_011542839.3 XP_011541141.1 melatonin receptor type 1B isoform X2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20859254 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
20668700 GOA
involved in regulation of insulin secretion IMP
IMP: 通过突变表型推断
20668700 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MTNR1B 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 308)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

melatonin receptor type 1B

mel1b receptor

melatonin receptor MEL1B

关联疾病

疾病名称 别名
Scoliosis
Glucose Intolerance

Glucose: Intolerance

Glucose: Malabsorption

Malabsorption Of Glucose

Impaired Glucose Tolerance
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Idiopathic Scoliosis

Scoliosis Idiopathic
Spermatogenic Failure 24

SPGF24

Spermatogenic Failure, Type 24
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Diabetes Mellitus

Diabetes
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08807 Mtnr1b Mouse Pre-designed siRNA Set A / 否
HY-RS08806 MTNR1B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08808 Mtnr1b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MTNR1B VGNC VGNC:68351
Mus musculus MTNR1B MGD MGI:2181726
Canis familiaris MTNR1B VGNC VGNC:52269
Rattus norvegicus MTNR1B RGD RGD:620798
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