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  2. MTNR1A - melatonin receptor 1A Gene

MTNR1A - melatonin receptor 1A Gene

中文名称:褪黑激素受体 1A

种属: Homo sapiens

同用名: MT1; MEL-1A-R

基因 ID: 4543 | 基因类型: protein coding

关于 MTNR1A

Cytogenetic location: 4q35.2 Genomic coordinates (GRCh38): 4:186,533,655-186,555,567 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 33 paralogues. Biased expression in kidney (RPKM 1.1), testis (RPKM 0.6) and 8 other tissues.

功能概要

该基因编码褪黑激素受体的两种高亲和力形式之一,褪黑激素是松果体分泌的主要激素。该受体是一种 G 蛋白偶联的 7 次跨膜受体,负责褪黑激素对哺乳动物昼夜节律的影响和受日长影响的生殖改变。该受体是一种完整的膜蛋白,很容易被检测到并定位于大脑的两个特定区域。下丘脑视交叉上核似乎与昼夜节律有关,而垂体结节部可能负责褪黑激素的生殖作用。[RefSeq 提供,2008 年 7 月]

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

MTNR1A 基因产物(2)

mRNA Protein Name
NM_005958.4 NP_005949.1 melatonin receptor type 1A
XM_011532002.4 XP_011530304.1 melatonin receptor type 1A isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone binding IPI
IPI: 通过物理相互作用推断
10531408 GOA
enables melatonin receptor activity IDA
IDA: 通过直接分析推断
10531408 GOA
enables organic cyclic compound binding IPI
IPI: 通过物理相互作用推断
10531408 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17215244 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
10531408 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
10531408 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
10531408 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MTNR1A 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 295)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

melatonin receptor type 1A

mel1a receptor

MTNR1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MTNR1A P48039 TMEM33 Homo sapiens P57088
TAP
17215244
种属内
MTNR1A P48039 TMEM33 Homo sapiens P57088
TAP
26514267
种属内
MTNR1A P48039 CALR Homo sapiens P27797 28298427
种属内
MTNR1A P48039 CALR Homo sapiens P27797
TAP
17215244
种属内
MTNR1A P48039 CALR Homo sapiens P27797
TAP
26514267
种属内
MTNR1A P48039 RGS20 Homo sapiens O76081 20859254
种属内
MTNR1A P48039 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
MTNR1A P48039 KRTAP1-3 Homo sapiens Q8IUG1 32296183
种属内
MTNR1A P48039 CYSRT1 Homo sapiens A8MQ03 32296183
种属内
MTNR1A P48039 CYSRT1 Homo sapiens A8MQ03 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

MTNR1A 抗体

目录号 产品名 应用 反应物种
HY-P81119 MTNR1A Antibody WB, ELISA, IHC-P, IHC-F, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Delayed Sleep Phase Disorder

Delayed Sleep Phase Syndrome

Delayed Sleep Phase Syndrome, Susceptibility To

DSPD

Delayed Sleep Phase Disorder, Susceptibility To

DSPS

Sleep Phase, Delayed, Disorder

Sleep Phase Syndrome, Delayed, Susceptibility To

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Deafness, Autosomal Dominant 24

DFNA24

Autosomal Dominant Nonsyndromic Deafness 24

Autosomal Dominant Deafness 24

Nephrolithiasis

Kidney Stones

Stone - Kidney/Ureter

Kidney Calculi

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Scoliosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus MTNR1A VGNC VGNC:31746
Canis familiaris MTNR1A VGNC VGNC:110519
Mus musculus MTNR1A MGD MGI:102967
Rattus norvegicus MTNR1A RGD RGD:620797
Macaca mulatta MTNR1A VGNC VGNC:81477
Felis catus MTNR1A VGNC VGNC:78528