2. Gene
  3. TMEM33 - transmembrane protein 33 Gene

TMEM33 - transmembrane protein 33 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜蛋白 33

种属: Homo sapiens

同用名: Pom33; SHINC3; SHINC-3; 1600019D15Rik

基因 ID: 55161 | 基因类型: protein coding

关于 TMEM33

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:41,935,137-41,960,803 (from NCBI)

This gene has 8 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 8.6), thyroid (RPKM 8.4) and 25 other tissues.

功能概要

参与内质网未折叠蛋白反应的正调控；调节内质网管状网络组织；和对内质网应激的反应。位于内质网膜；黑素体;和核膜。是内质网膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM33 基因产物(1)

mRNA Protein Name
NM_018126.3 NP_060596.2 transmembrane protein 33
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17215244 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of IRE1-mediated unfolded protein response IDA
IDA: 通过直接分析推断
26268696 GOA
involved in positive regulation of PERK-mediated unfolded protein response IDA
IDA: 通过直接分析推断
26268696 GOA
involved in regulation of endoplasmic reticulum tubular network organization IDA
IDA: 通过直接分析推断
25612671 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
26268696 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
25612671 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
25612671 GOA
located in melanosome IDA
IDA: 通过直接分析推断
17081065 GOA
located in nuclear envelope IDA
IDA: 通过直接分析推断
25612671 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMEM33 蛋白结构

UPF0121

UPF0121: Uncharacterised protein family (UPF0121) (3 - 246)

  • 0
  • 100
  • 200
  • 247 a.a.
蛋白主名 其他名称

transmembrane protein 33

TMEM33 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMEM33 P57088 MTNR1A Homo sapiens P48039
Ub Reconstruction
28298427
种属内
TMEM33 P57088 q96fb2_human Homo sapiens Q96FB2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14717 TMEM33 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TMEM33 RGD RGD:708371
Macaca mulatta TMEM33 VGNC VGNC:79511
Felis catus TMEM33 VGNC VGNC:107476
Canis familiaris TMEM33 VGNC VGNC:47571
Bos taurus TMEM33 VGNC VGNC:36076
Mus musculus TMEM33 MGD MGI:1915128
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