RGS20 - regulator of G protein signaling 20 Gene

中文名称：G 蛋白信号调节器 20

种属: Homo sapiens

同用名: RGSZ1; ZGAP1; gz-GAP; g(z)GAP

关于 RGS20

功能概要

该基因编码的蛋白质属于 G 蛋白信号转导调节蛋白 (RGS) 家族，是 G 蛋白偶联受体复合物的调节和结构成分。 RGS 蛋白通过增加 G 蛋白 α 亚基的 GTP 酶活性来抑制信号转导，从而将它们驱动为无活性的 GDP 结合形式。这种蛋白质选择性地绑定到 G (z) -alpha 和 G (alpha) -i2 亚基，并调节它们的信号活动。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]