1. Gene
  2. MAPKBP1 - mitogen-activated protein kinase binding protein 1 Gene

MAPKBP1 - mitogen-activated protein kinase binding protein 1 Gene

中文名称:丝裂原活化蛋白激酶结合蛋白 1

种属: Homo sapiens

同用名: JNKBP1; NPHP20; JNKBP-1

基因 ID: 23005 | 基因类型: protein coding

关于 MAPKBP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,774,484-41,827,855 (from NCBI)

This gene has 17 transcripts (splice variants), 121 orthologues, 26 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 16.2), skin (RPKM 11.0) and 23 other tissues.

功能概要

该基因编码一种支架蛋白,可调节 JNK (c-Jun N 末端激酶) 和 NOD2 (含核苷酸结合寡聚化结构域的蛋白 2) 信号通路。编码的蛋白质通过保守的二聚化结构域与另一个相关的 JNK 通路支架蛋白 WDR62 相互作用,并增强 JNK 信号传导。这种蛋白质可能通过与 NOD2 受体结合并负向调节下游抗菌和促炎信号而在细菌免疫中发挥作用。该基因的突变会损害所编码蛋白质的细胞定位,从而导致人类患者患上一种肾病,一种常染色体隐性肾病。[RefSeq 提供,2017 年 5 月]

This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in Bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream Antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

MAPKBP1 基因产物(3)

mRNA Protein Name
NM_001128608.2 NP_001122080.1 mitogen-activated protein kinase-binding protein 1 isoform b
NM_001265611.2 NP_001252540.1 mitogen-activated protein kinase-binding protein 1 isoform c
NM_014994.3 NP_055809.2 mitogen-activated protein kinase-binding protein 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22700971 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
22700971 GOA
involved in negative regulation of defense response to bacterium IMP
IMP: 通过突变表型推断
22700971 GOA
involved in negative regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
22700971 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28089251 GOA
located in mitotic spindle pole IDA
IDA: 通过直接分析推断
28089251 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MAPKBP1 蛋白结构

WD40

WD40: WD domain, G-beta repeat (82 - 108)

WD40

WD40: WD domain, G-beta repeat (126 - 163)

WD40

WD40: WD domain, G-beta repeat (178 - 203)

WD40

WD40: WD domain, G-beta repeat (285 - 306)

WD40

WD40: WD domain, G-beta repeat (388 - 427)

WD40

WD40: WD domain, G-beta repeat (481 - 505)

WD40

WD40: WD domain, G-beta repeat (517 - 550)

WD40

WD40: WD domain, G-beta repeat (559 - 594)

WD40

WD40: WD domain, G-beta repeat (693 - 730)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1514 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase-binding protein 1

JNK-binding protein 1

MAPKBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MAPKBP1 O60336 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra MAPKBP1 O60336 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Validated Y2H
32296183
Intra MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
Intra MAPKBP1 O60336 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra MAPKBP1 O60336 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 METTL15 Homo sapiens A6NJ78-4
Y2H Array
32296183
Intra MAPKBP1 O60336 RGS20 Homo sapiens O76081-6
Y2H Array
25416956
Intra MAPKBP1 O60336 ALG13 Homo sapiens Q9NP73-4
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 ALG13 Homo sapiens Q9NP73-4
Validated Y2H
25416956
Intra MAPKBP1 O60336 TEKT5 Homo sapiens Q96M29
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 TEKT5 Homo sapiens Q96M29
Validated Y2H
32296183
Intra MAPKBP1 O60336 TEKT5 Homo sapiens Q96M29
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 KRT34 Homo sapiens O76011
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra MAPKBP1 O60336 KRT38 Homo sapiens O76015
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra MAPKBP1 O60336 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra MAPKBP1 O60336 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra MAPKBP1 O60336 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra MAPKBP1 O60336 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra MAPKBP1 O60336 FOXN1 Homo sapiens O15353
Y2H Array
32296183
Intra MAPKBP1 O60336 FOXN1 Homo sapiens O15353
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 TEX11 Homo sapiens Q8IYF3-3
Validated Y2H
32296183
Intra MAPKBP1 O60336 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
Intra MAPKBP1 O60336 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 YPEL5 Homo sapiens P62699
Y2H Array
32296183
Intra MAPKBP1 O60336 YPEL5 Homo sapiens P62699
Validated Y2H
32296183
Intra MAPKBP1 O60336 YPEL5 Homo sapiens P62699
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP12-3 Homo sapiens P60328
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 ADAM12 Homo sapiens O43184-4
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 ADAM12 Homo sapiens O43184-4
Y2H Array
32296183
Intra MAPKBP1 O60336 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra MAPKBP1 O60336 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra MAPKBP1 O60336 TCF4 Homo sapiens P15884-3
Validated Y2H
32296183
Intra MAPKBP1 O60336 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra MAPKBP1 O60336 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra MAPKBP1 O60336 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra MAPKBP1 O60336 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra MAPKBP1 O60336 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra MAPKBP1 O60336 RBCK1 Homo sapiens Q9BYM8
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
32296183
Intra MAPKBP1 O60336 RBCK1 Homo sapiens Q9BYM8
Y2H Array
32296183
Intra MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Validated Y2H
32296183
Intra MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Y2H Array
32296183
Intra MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Validated Y2H
25416956
Intra MAPKBP1 O60336 GLRX3 Homo sapiens O76003
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra MAPKBP1 O60336 MYOG Homo sapiens P15173
Validated Y2H
32296183
Intra MAPKBP1 O60336 MYOG Homo sapiens P15173
Y2H Array
32296183
Intra MAPKBP1 O60336 MYOG Homo sapiens P15173
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP26-1 Homo sapiens Q6PEX3
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra MAPKBP1 O60336 KRTAP5-9 Homo sapiens P26371
Validated Y2H
32296183
Intra MAPKBP1 O60336 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra MAPKBP1 O60336 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
Intra MAPKBP1 O60336 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra MAPKBP1 O60336 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra MAPKBP1 O60336 TCF12 Homo sapiens Q99081
Y2H Array
25416956
Intra MAPKBP1 O60336 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra MAPKBP1 O60336 MDFI Homo sapiens Q99750
Y2H Array
25416956
Intra MAPKBP1 O60336 PLA2G10 Homo sapiens O15496
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 PLA2G10 Homo sapiens O15496
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
25416956
Intra MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
32296183
Intra MAPKBP1 O60336 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra MAPKBP1 O60336 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra MAPKBP1 O60336 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Intra MAPKBP1 O60336 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra MAPKBP1 O60336 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra MAPKBP1 O60336 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
32296183
Intra MAPKBP1 O60336 PLSCR3 Homo sapiens Q9NRY6
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
25416956
Intra MAPKBP1 O60336 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra MAPKBP1 O60336 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra MAPKBP1 O60336 q7z783_human Homo sapiens Q7Z783
Y2H Array
25416956
Intra MAPKBP1 O60336 q7z783_human Homo sapiens Q7Z783
Validated Y2H
25416956
Intra MAPKBP1 O60336 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra MAPKBP1 O60336 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra MAPKBP1 O60336 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra MAPKBP1 O60336 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra MAPKBP1 O60336 KRT86 Homo sapiens O43790
Y2H Array
32296183
Intra MAPKBP1 O60336 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephronophthisis 20

NPHP20

Late-Onset Nephronophthisis
Juvenile Nephronophthisis

Nephronophthisis

Nephronophthisis, Familial Juvenile

Nephronophthisis

Medullary Cystic Disease

Medullary Cystic Kidney

Nph

Nphp

Kidney Disease, Cystic, Medullary

Nephronophthisis 7

NPHP7

Nephronophthisis, Type 7

Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1

Nevo Syndrome

Eds Vi

Ehlers-Danlos Syndrome, Type Vi

Eds Via

Ehlers-Danlos Syndrome Type 6

EDSKSCL1

Eds6

Ehlers-Danlos Syndrome Kyphoscoliotic Type 1

Kyphoscoliotic Ehlers-Danlos Syndrome

Cutis Hyperelastica

Ehlers-Danlos Syndrome Type 6a

Ehlers-Danlos Syndrome Oculoscoliotic Type

Kyphoscoliotic Eds

Kyphoscoliotic Eds Due To Lysyl Hydroxylase 1 Deficiency

Kyphoscoliotic Ehlers-Danlos Syndrome Due To Lysyl Hydroxylase 1 Deficiency

Lysyl Hydroxylase-Deficient Eds

Ocular-Scoliotic Eds

Keds

Keds-Plod1

Ehlers-Danlos Syndrome, Kyphoscoliotic Type 1

Ehlers-Danlos Syndrome, Ocular-Scoliotic Type

Ehlers-Danlos Syndrome, Type Via, Formerly

Eds6a, Formerly

Eds 6

Eds, Kyphoscoliotic Type

Eds, Oculoscoliotic Type

Ehlers-Danlos Syndrome, Kyphoscoliosis Type

Ehlers-Danlos Syndrome, Kyphoscoliotic Type

Ehlers-Danlos Syndrome, Oculoscoliotic Type

Eds6a

Ehlers-Danlos Syndrome 6

Ehlers-Danlos Syndrome Kyphoscoliotic Type

Interstitial Nephritis

Nephritis, Interstitial

Renal Tubulo-Interstitial Disease

Nephritis Interstitial

Nephritis, Tubulointerstitial

Nephronophthisis 16

NPHP16

Nephronophthisis, Type 16

Nephronophthisis 14

Joubert Syndrome 19

NPHP14

JBTS19

Nephronophthisis, Type 14

Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MAPKBP1 VGNC VGNC:43009
Rattus norvegicus MAPKBP1 RGD RGD:1307578
Mus musculus MAPKBP1 MGD MGI:1347004
Bos taurus MAPKBP1 VGNC VGNC:31231
Macaca mulatta MAPKBP1 VGNC VGNC:74613