KRT38 - keratin 38 Gene

中文名称：角蛋白 38

种属: Homo sapiens

同用名: HA8; hHa8; KRTHA8

基因 ID: 8687 | 基因类型: protein coding

关于 KRT38

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,436,154-41,440,983 (from NCBI)

This gene has 1 transcript (splice variant), 29 orthologues and 68 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是角蛋白基因家族的一员。作为 I 型毛发角蛋白，它是一种酸性蛋白质，可与 II 型角蛋白异二聚化形成毛发和指甲。 I 型毛发角蛋白聚集在染色体 17q12-q21 的一个区域，具有相同的转录方向。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

KRT38 基因产物(1)

mRNA	Protein	Name
NM_006771.4	NP_006762.3	keratin, type I cuticular Ha8

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT38 蛋白结构

Filament

0
100
200
300
400
456 a.a.

蛋白主名

其他名称

keratin, type I cuticular Ha8

K38

KRT38 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KRT38	O76015	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
种属内	KRT38	O76015	AMOTL2	Homo sapiens	Q9Y2J4-4	Validated Y2H	25416956
种属内	KRT38	O76015	AMOTL2	Homo sapiens	Q9Y2J4-4	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	GNG10	Homo sapiens	P50151	Validated Y2H	25416956
种属内	KRT38	O76015	KRT83	Homo sapiens	P78385	Validated Y2H	32296183
种属内	KRT38	O76015	KRT83	Homo sapiens	P78385	Y2H Array	25416956
种属内	KRT38	O76015	PTGER3	Homo sapiens	P43115-12	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	PTGER3	Homo sapiens	P43115-12	Validated Y2H	25416956
种属内	KRT38	O76015	PTGER3	Homo sapiens	P43115-12	Y2H Array	25416956
种属内	KRT38	O76015	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	CCDC146	Homo sapiens	Q8IYE0-2	Y2H Array	25416956
种属内	KRT38	O76015	CCDC146	Homo sapiens	Q8IYE0-2	Validated Y2H	25416956
种属内	KRT38	O76015	RHPN1-AS1	Homo sapiens	Q9BWJ2	Validated Y2H	25416956
种属内	KRT38	O76015	CD300A	Homo sapiens	Q9UGN4	Validated Y2H	25416956
种属内	KRT38	O76015	KRT85	Homo sapiens	P78386	Validated Y2H	32296183
种属内	KRT38	O76015	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
种属内	KRT38	O76015	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
种属内	KRT38	O76015	GNG13	Homo sapiens	Q9P2W3	Validated Y2H	32296183
种属内	KRT38	O76015	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
种属内	KRT38	O76015	KRT80	Homo sapiens	Q6KB66-2	Validated Y2H	32296183
种属内	KRT38	O76015	TBC1D21	Homo sapiens	Q8IYX1	Validated Y2H	32296183
种属内	KRT38	O76015	HSF4	Homo sapiens	Q9ULV5-2	Validated Y2H	32296183
种属内	KRT38	O76015	KRT72	Homo sapiens	Q14CN4	Validated Y2H	32296183
种属内	KRT38	O76015	KRT72	Homo sapiens	Q14CN4	Y2H Array	32296183
种属内	KRT38	O76015	KRT2	Homo sapiens	P35908	Y2H Array	31515488
种属内	KRT38	O76015	KRT2	Homo sapiens	P35908	Validated Y2H	25416956
种属内	KRT38	O76015	KRT2	Homo sapiens	P35908	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
种属内	KRT38	O76015	POU4F2	Homo sapiens	Q12837	Validated Y2H	32296183
种属内	KRT38	O76015	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
种属内	KRT38	O76015	KRT4	Homo sapiens	P19013	Validated Y2H	32296183
种属内	KRT38	O76015	KRT4	Homo sapiens	P19013	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	KRT3	Homo sapiens	P12035	Validated Y2H	32296183
种属内	KRT38	O76015	KRT79	Homo sapiens	Q5XKE5	Y2H Array	31515488
种属内	KRT38	O76015	KRT79	Homo sapiens	Q5XKE5	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	HAUS1	Homo sapiens	Q96CS2	Anti Tag CoIP	33961781
种属内	KRT38	O76015	KRT6C	Homo sapiens	P48668	Y2H Array	25416956
种属内	KRT38	O76015	KRT6C	Homo sapiens	P48668	Validated Y2H	25416956
种属内	KRT38	O76015	KRT6C	Homo sapiens	P48668	Validated Y2H	32296183
种属内	KRT38	O76015	LMO4	Homo sapiens	P61968	Validated Y2H	32296183
种属内	KRT38	O76015	TXNDC5	Homo sapiens	Q86UY0	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	TXNDC5	Homo sapiens	Q86UY0	Validated Y2H	25416956
种属内	KRT38	O76015	ZFYVE21	Homo sapiens	Q9BQ24	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	KRT75	Homo sapiens	O95678	Validated Y2H	32296183
种属内	KRT38	O76015	KRT71	Homo sapiens	Q3SY84	Validated Y2H	25416956
种属内	KRT38	O76015	KRT71	Homo sapiens	Q3SY84	Validated Y2H	32296183
种属内	KRT38	O76015	KRT71	Homo sapiens	Q3SY84	Y2H Array	25416956
种属内	KRT38	O76015	KRT76	Homo sapiens	Q01546	Validated Y2H	32296183
种属内	KRT38	O76015	KRT8	Homo sapiens	P05787	Validated Y2H	25416956
种属内	KRT38	O76015	KRT8	Homo sapiens	P05787	Validated Y2H	32296183
种属内	KRT38	O76015	KRT8	Homo sapiens	P05787	Y2H Array	25416956
种属内	KRT38	O76015	KRT8	Homo sapiens	P05787	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	KRT1	Homo sapiens	P04264	Validated Y2H	32296183
种属内	KRT38	O76015	HDAC4	Homo sapiens	P56524	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	PIK3R2	Homo sapiens	O00459	Validated Y2H	25416956
种属内	KRT38	O76015	PIK3R2	Homo sapiens	O00459	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	PSMC5	Homo sapiens	P62195	Validated Y2H	25416956
种属内	KRT38	O76015	PSMC5	Homo sapiens	P62195	Y2H Array	25416956
种属内	KRT38	O76015	PSMC5	Homo sapiens	P62195	Y2H Array	29892012
种属内	KRT38	O76015	PSMC5	Homo sapiens	P62195	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
种属内	KRT38	O76015	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
种属内	KRT38	O76015	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
种属内	KRT38	O76015	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	TXLNA	Homo sapiens	P40222	Anti Tag CoIP	33961781
种属内	KRT38	O76015	TXLNA	Homo sapiens	P40222	Y2H Array	31515488
种属内	KRT38	O76015	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
种属内	KRT38	O76015	UTP23	Homo sapiens	Q9BRU9	Validated Y2H	32296183
种属内	KRT38	O76015	TXLNB	Homo sapiens	Q8N3L3	Validated Y2H	32296183
种属内	KRT38	O76015	TXLNB	Homo sapiens	Q8N3L3	Y2H Array	32296183
种属内	KRT38	O76015	TXLNB	Homo sapiens	Q8N3L3	Y2H Array	31515488
种属内	KRT38	O76015	KLHL38	Homo sapiens	Q2WGJ6	Y2H Array	25416956
种属内	KRT38	O76015	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	25416956
种属内	KRT38	O76015	KLHL38	Homo sapiens	Q2WGJ6	Validated Y2H	32296183
种属内	KRT38	O76015	ZNF587	Homo sapiens	Q96SQ5	Y2H Array	25416956
种属内	KRT38	O76015	FAM90A1	Homo sapiens	Q86YD7	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	25416956
种属内	KRT38	O76015	FAM90A1	Homo sapiens	Q86YD7	Y2H Array	25416956
种属内	KRT38	O76015	KRT5	Homo sapiens	P13647	Validated Y2H	32296183
种属内	KRT38	O76015	KRT5	Homo sapiens	P13647	Y2H Array	25416956
种属内	KRT38	O76015	KRT6A	Homo sapiens	P02538	Validated Y2H	32296183
种属内	KRT38	O76015	KRT6A	Homo sapiens	P02538	Y2H Array	31515488
种属内	KRT38	O76015	KRT6A	Homo sapiens	P02538	Validated Y2H	25416956
种属内	KRT38	O76015	HMG20B	Homo sapiens	Q9P0W2	MAPPIT	25416956
种属内	KRT38	O76015	HMG20B	Homo sapiens	Q9P0W2	Y2H Array	25416956
种属内	KRT38	O76015	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
种属内	KRT38	O76015	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
种属内	KRT38	O76015	ZNF20	Homo sapiens	P17024	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	ZNF20	Homo sapiens	P17024	Validated Y2H	25416956
种属内	KRT38	O76015	KRT81	Homo sapiens	Q14533	Y2H Array	25416956
种属内	KRT38	O76015	KRT81	Homo sapiens	Q14533	Validated Y2H	25416956
种属内	KRT38	O76015	KRT81	Homo sapiens	Q14533	Validated Y2H	32296183
种属内	KRT38	O76015	KRT81	Homo sapiens	Q14533	Anti Tag CoIP	25416956
种属内	KRT38	O76015	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
种属内	KRT38	O76015	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
种属内	KRT38	O76015	HGS	Homo sapiens	O14964	Validated Y2H	25416956
种属内	KRT38	O76015	HGS	Homo sapiens	O14964	Y2H Array	25416956
种属内	KRT38	O76015	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	25416956
种属内	KRT38	O76015	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
种属内	KRT38	O76015	ZNF417	Homo sapiens	Q8TAU3	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	ZNF417	Homo sapiens	Q8TAU3	Y2H Array	25416956
种属内	KRT38	O76015	HOXA1	Homo sapiens	P49639	Validated Y2H	32296183
种属内	KRT38	O76015	HOXA1	Homo sapiens	P49639	Validated Y2H	25416956
种属内	KRT38	O76015	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	HOXA1	Homo sapiens	P49639	Y2H Array	25416956
种属内	KRT38	O76015	KRT6B	Homo sapiens	P04259	Y2H Array	25416956
种属内	KRT38	O76015	KRT6B	Homo sapiens	P04259	Validated Y2H	32296183
种属内	KRT38	O76015	KRT6B	Homo sapiens	P04259	Complementation	32296183
种属内	KRT38	O76015	BRME1	Homo sapiens	Q0VDD7	Y2H Array	25416956
种属内	KRT38	O76015	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
种属内	KRT38	O76015	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
种属内	KRT38	O76015	ANKRD36BP1	Homo sapiens	Q96IX9	Y2H Array	25416956
种属内	KRT38	O76015	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
种属内	KRT38	O76015	C1orf216	Homo sapiens	Q8TAB5	Y2H Array	25416956
种属内	KRT38	O76015	C1orf216	Homo sapiens	Q8TAB5	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
种属内	KRT38	O76015	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
种属内	KRT38	O76015	SCNM1	Homo sapiens	Q9BWG6	Y2H Array	31515488
种属内	KRT38	O76015	MAGEB4	Homo sapiens	O15481	Validated Y2H	25416956
种属内	KRT38	O76015	MAGEB4	Homo sapiens	O15481	Y2H Array	25416956
种属内	KRT38	O76015	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183
种属内	KRT38	O76015	KRT74	Homo sapiens	Q7RTS7	Validated Y2H	32296183
种属内	KRT38	O76015	a8k2r3_human	Homo sapiens	A8K2R3	Y2H Prey Pooling	25416956
种属内	KRT38	O76015	a8k2r3_human	Homo sapiens	A8K2R3	Y2H Array	25416956
种属内	KRT38	O76015	a8k2r3_human	Homo sapiens	A8K2R3	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nodular Basal Cell Carcinoma

Basal Cell Carcinoma, Nodular	Circumscribed Solid Basal Cell Carcinoma
Skin Nodulo-Ulcerative Basal Cell Carcinoma	Skin Solid Basal Cell Carcinoma
Skin Nodular Basal Cell Carcinoma	Skin Nodular Solid Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Circumscribed Solid Basal Cell Carcinoma Of Skin

Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita	Anonychia
Hyponychia Congenita	NDNC4
Anonychia/Hyponychia Congenita	Nonsyndromic Congenital Nail Disorder 4
Isolated Congenital Anonychia	Anonychia Congenita Totalis
Anonychia Totalis	Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4
Congenital Anonychia	Nonsyndromic Congenital Nail Disorder, 4
Absent Nails	Aplastic Nails
Congenital Absence Of Nails	Isolated Anonychia
Nail Disorder, Non-Syndromic Congenital, 4	Nail Disorder, Nonsyndromic, Congenital, Type 4

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.