2. Gene
  3. KRT6C - keratin 6C Gene

KRT6C - keratin 6C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白 6C

种属: Homo sapiens

同用名: K6E; KRT6E; PPKNEFD

基因 ID: 286887 | 基因类型: protein coding

关于 KRT6C

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,468,516-52,473,805 (from NCBI)

This gene has 2 transcripts (splice variants), 143 orthologues, 68 paralogues and is associated with 2 phenotypes. Restricted expression toward esophagus (RPKM 948.5).

功能概要

角蛋白是负责上皮细胞结构完整性的中间丝蛋白，分为上皮角蛋白和毛发角蛋白。 II 型角蛋白聚集在染色体 12q13 的区域。[RefSeq 提供，2009 年 7 月]

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009]

KRT6C 基因产物(1)

mRNA Protein Name
NM_173086.5 NP_775109.2 keratin, type II cytoskeletal 6C
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intermediate filament cytoskeleton organization IMP
IMP: 通过突变表型推断
23662636 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KRT6C 蛋白结构

Filament

Filament: Intermediate filament protein (162 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 564 a.a.
蛋白主名 其他名称

keratin, type II cytoskeletal 6C

CK-6C

KRT6C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KRT6C P48668 KRT13 Homo sapiens A1A4E9
Y2H Prey Pooling
25416956
Intra KRT6C P48668 KRT13 Homo sapiens A1A4E9
Validated Y2H
25416956
Intra KRT6C P48668 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra KRT6C P48668 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra KRT6C P48668 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT40 Homo sapiens Q6A162
Validated Y2H
32296183
Intra KRT6C P48668 KRT37 Homo sapiens O76014
Y2H Array
32296183
Intra KRT6C P48668 KRT37 Homo sapiens O76014
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra KRT6C P48668 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT38 Homo sapiens O76015
Y2H Array
32296183
Intra KRT6C P48668 KRT38 Homo sapiens O76015
Y2H Prey Pooling
25416956
Intra KRT6C P48668 KRT38 Homo sapiens O76015
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT33B Homo sapiens Q14525
Y2H Array
32296183
Intra KRT6C P48668 KRT33B Homo sapiens Q14525
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT33B Homo sapiens Q14525
Validated Y2H
32296183
Intra KRT6C P48668 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra KRT6C P48668 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra KRT6C P48668 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra KRT6C P48668 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra KRT6C P48668 KRT25 Homo sapiens Q7Z3Z0
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT25 Homo sapiens Q7Z3Z0
Validated Y2H
32296183
Intra KRT6C P48668 KRT25 Homo sapiens Q7Z3Z0
Y2H Array
32296183
Intra KRT6C P48668 KRT26 Homo sapiens Q7Z3Y9
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT26 Homo sapiens Q7Z3Y9
Y2H Array
32296183
Intra KRT6C P48668 KRT26 Homo sapiens Q7Z3Y9
Validated Y2H
32296183
Intra KRT6C P48668 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra KRT6C P48668 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra KRT6C P48668 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra KRT6C P48668 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra KRT6C P48668 ACTN3 Homo sapiens Q08043
Validated Y2H
32296183
Intra KRT6C P48668 KRT24 Homo sapiens Q2M2I5
Validated Y2H
32296183
Intra KRT6C P48668 KRT24 Homo sapiens Q2M2I5
Y2H Array
32296183
Intra KRT6C P48668 KRT24 Homo sapiens Q2M2I5
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT18 Homo sapiens P05783
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT18 Homo sapiens P05783
Y2H Array
32296183
Intra KRT6C P48668 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT27 Homo sapiens Q7Z3Y8
Validated Y2H
32296183
Intra KRT6C P48668 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra KRT6C P48668 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra KRT6C P48668 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra KRT6C P48668 KRT14 Homo sapiens P02533
Y2H Array
32296183
Intra KRT6C P48668 KRT15 Homo sapiens P19012
Y2H Array
25416956
Intra KRT6C P48668 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra KRT6C P48668 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Intra KRT6C P48668 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra KRT6C P48668 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra KRT6C P48668 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse

PPKNEFD

Focal Or Diffuse Nonepidermolytic Palmoplantar Keratoderma

Autosomal Dominant Focal Non-Epidermolytic Palmoplantar Keratoderma With Plantar Blistering

Palmoplantar Keratoderma, Non-Epidermolytic, Focal Or Diffuse

Nonepidermolytic Focal Or Diffuse Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Nonepidermolytic, Focal Or Diffuse
Focal Palmoplantar Keratoderma

Focal Ppk

Focal Keratosis Palmoplantaris

Focal Palmoplantar Hyperkeratosis
Diffuse Palmoplantar Keratoderma

Diffuse Palmoplantar Hyperkeratosis

Diffuse Ppk

Diffuse Keratosis Palmoplantaris
Norwegian Scabies

Crusted Scabies

Seven Year Itch
Pachyonychia Congenita 1

Pachyonychia Congenita

Jadassohn-Lewandowsky Syndrome

Pachyonychia Congenita Syndrome

PC1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type

Congenital Pachyonychia

Pachyonychia Congenita, Type 1

Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly

Jadassohn-Lewandowsky Syndrome, Formerly

Jackson-Lawler Type Pachyonychia Congenita

Pachyonychia Congenita Type 1

Jackson-Lawler Syndrome

Jadassohn-Lewandowski Syndrome

Pc

Pachyonychia Congenita Jackson-Lawler Type

Pachyonychia Congenita Jadassohn-Lewandowsky Type

Pachyonychia Congenita Jackson Lawler Type

Pc-1

Pachyonychia Congenita, Jadassohn Lewandowsky Type

Pachyonychia Congenita, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07460 KRT6C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KRT6C RGD RGD:1588056
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