TFIP11 - tuftelin interacting protein 11 Gene

中文名称：tuftelin 相互作用蛋白 11

种属: Homo sapiens

同用名: NTR1; STIP; TIP39; STIP-1; Spp382; bK445C9.6

关于 TFIP11

功能概要

该基因编码剪接体的一种蛋白质成分，该成分通过募集一种称为 DEAH-box 解旋酶 15 的前 mRNA 剪接因子，在后期剪接过程中促进套索内含子的释放。编码的蛋白质包含一个 G-patch 结构域，结合 DEAH 盒解旋酶 15 的 RNA 加工蛋白的标志。该蛋白包含一个非典型核定位序列以及一个核斑点靶向序列，使其能够定位到细胞核内不同的斑点区域。该基因的多态性与龋齿有关，表明在釉质形成中起作用。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 11 月]

This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]