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  2. GCFC2 - GC-rich sequence DNA-binding factor 2 Gene

GCFC2 - GC-rich sequence DNA-binding factor 2 Gene

中文名称:富 GC 序列的 DNA 结合因子 2

种属: Homo sapiens

同用名: GCF; TCF9; DNABF; C2orf3

基因 ID: 6936 | 基因类型: protein coding

关于 GCFC2

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:75,662,705-75,713,122 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.0), testis (RPKM 4.3) and 25 other tissues.

功能概要

为该基因分离的第一个 mRNA 转录本是人工嵌合体的一部分,该人工嵌合体源自两个不同的基因转录本和克隆过程中使用的引物 (参见 Genbank 登录号 M29204) 。仅存在于嵌合体中的带正电荷的氨基末端被确定为结合富含 GC 的 DNA,因此被错误地认为是识别转录因子基因。[RefSeq 提供,2008 年 7 月]

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]

GCFC2 基因产物(4)

mRNA Protein Name
NM_001201334.2 NP_001188263.1 intron Large complex component GCFC2 isoform 2
NM_001201335.2 NP_001188264.1 intron Large complex component GCFC2 isoform 3
NM_001410845.1 NP_001397774.1 intron Large complex component GCFC2 isoform 4
NM_003203.5 NP_003194.3 intron Large complex component GCFC2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24304693 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in spliceosomal complex assembly IMP
IMP: 通过突变表型推断
24304693 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type post-mRNA release spliceosomal complex IDA
IDA: 通过直接分析推断
24304693 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
24304693 GOA
located in nucleus IDA
IDA: 通过直接分析推断
24304693 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GCFC2 蛋白结构

GCFC

GCFC: GC-rich sequence DNA-binding factor-like protein (468 - 681)

  • 0
  • 200
  • 400
  • 600
  • 781 a.a.
蛋白主名 其他名称

intron Large complex component GCFC2

GC binding factor

GCFC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9 32296183
种属内
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9 32296183
种属内
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9 24304693
种属内
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyslexia
Reading Disorder

Specific Reading Disorder

Reading

Dyslexia

Developmental Reading Disorder

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Specific Language Impairment

Language Impairment, Specific

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus GCFC2 VGNC VGNC:62490
Mus musculus GCFC2 MGD MGI:2141656
Rattus norvegicus GCFC2 RGD RGD:1304792
Canis familiaris GCFC2 VGNC VGNC:41142
Bos taurus GCFC2 VGNC VGNC:29283
Macaca mulatta GCFC2 VGNC VGNC:72715