DISC1 - DISC1 scaffold protein Gene

中文名称：DISC1 支架蛋白

种属: Homo sapiens

同用名: SCZD9; C1orf136

基因 ID: 27185 | 基因类型: protein coding

关于 DISC1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:231,626,790-232,041,272 (from NCBI)

This gene has 23 transcripts (splice variants), 194 orthologues and is associated with 2 phenotypes. Ubiquitous expression in placenta (RPKM 2.1), ovary (RPKM 1.4) and 24 other tissues.

功能概要

该基因编码一种具有多个卷曲螺旋基序的蛋白质，位于细胞核、细胞质和线粒体中。该蛋白质通过与其他蛋白质的相互作用参与神经突生长和皮质发育。该基因在 at (1;11) (q42.1;q14.3) 易位中被破坏，该易位与苏格兰大家族中的精神分裂症和相关精神疾病隔离开来。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with Other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DISC1 基因产物(23)

mRNA	Protein	Name
NM_001012957.2	NP_001012975.1	disrupted in schizophrenia 1 protein isoform Lv
NM_001012958.2	NP_001012976.1	disrupted in schizophrenia 1 protein isoform Es
NM_001012959.2	NP_001012977.1	disrupted in schizophrenia 1 protein isoform S
NM_001164537.2	NP_001158009.1	disrupted in schizophrenia 1 protein isoform a
NM_001164538.2	NP_001158010.1	disrupted in schizophrenia 1 protein isoform b
NM_001164539.2	NP_001158011.1	disrupted in schizophrenia 1 protein isoform c
NM_001164540.2	NP_001158012.1	disrupted in schizophrenia 1 protein isoform d
NM_001164541.2	NP_001158013.1	disrupted in schizophrenia 1 protein isoform e
NM_001164542.2	NP_001158014.1	disrupted in schizophrenia 1 protein isoform f
NM_001164544.2	NP_001158016.1	disrupted in schizophrenia 1 protein isoform g
NM_001164545.2	NP_001158017.1	disrupted in schizophrenia 1 protein isoform h
NM_001164546.2	NP_001158018.1	disrupted in schizophrenia 1 protein isoform i
NM_001164547.2	NP_001158019.1	disrupted in schizophrenia 1 protein isoform i
NM_001164548.2	NP_001158020.1	disrupted in schizophrenia 1 protein isoform k
NM_001164549.2	NP_001158021.1	disrupted in schizophrenia 1 protein isoform l
NM_001164550.2	NP_001158022.1	disrupted in schizophrenia 1 protein isoform m
NM_001164551.2	NP_001158023.1	disrupted in schizophrenia 1 protein isoform n
NM_001164552.2	NP_001158024.1	disrupted in schizophrenia 1 protein isoform o
NM_001164553.2	NP_001158025.1	disrupted in schizophrenia 1 protein isoform p
NM_001164554.2	NP_001158026.1	disrupted in schizophrenia 1 protein isoform q
NM_001164555.2	NP_001158027.1	disrupted in schizophrenia 1 protein isoform r
NM_001164556.2	NP_001158028.1	disrupted in schizophrenia 1 protein isoform t
NM_018662.3	NP_061132.2	disrupted in schizophrenia 1 protein isoform L

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	30561706	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12812986	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	18955030	GOA
involved in neuron migration	IMP IMP: 通过突变表型推断	19502360	GOA
acts upstream of or within non-motile cilium assembly	IMP IMP: 通过突变表型推断	20531939	GOA
involved in positive regulation of Wnt signaling pathway	IGI IGI: 通过遗传相互作用推断	19303846	GOA
involved in positive regulation of neuroblast proliferation	IGI IGI: 通过遗传相互作用推断	19303846	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in GABA-ergic synapse	IDA IDA: 通过直接分析推断	16736468	GOA
located in centrosome	IDA IDA: 通过直接分析推断	18762586	GOA
located in ciliary base	IDA IDA: 通过直接分析推断	20531939	GOA
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	16736468	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	20880836	GOA
is active in postsynaptic density	IDA IDA: 通过直接分析推断	16736468	GOA
is active in presynapse	IDA IDA: 通过直接分析推断	16736468	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

disrupted in schizophrenia 1 protein

DISC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DISC1	Q9NRI5	AKAP9	Homo sapiens	Q99996	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	AKAP9	Homo sapiens	Q99996	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	TNIK	Homo sapiens	Q9UKE5	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	TNIK	Homo sapiens	Q9UKE5	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	HERC2	Homo sapiens	O95714	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	HERC2	Homo sapiens	O95714	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	CLU	Homo sapiens	P10909	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	CEP170	Homo sapiens	Q5SW79	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	CEP170	Homo sapiens	Q5SW79	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	CEP170	Homo sapiens	Q5SW79	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	KIF3A	Homo sapiens	Q9Y496	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	KIF3C	Homo sapiens	O14782	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	PDE4DIP	Homo sapiens	Q5VU43	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	PDE4DIP	Homo sapiens	Q5VU43	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	TFIP11	Homo sapiens	Q9UBB9	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	TNKS	Homo sapiens	O95271	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	TNKS	Homo sapiens	O95271	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	ANGEL1	Homo sapiens	Q9UNK9	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	ANGEL1	Homo sapiens	Q9UNK9	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	ANKHD1	Homo sapiens	Q8IWZ3-1	Y2H	12812986
种属内	DISC1	Q9NRI5	ANKHD1	Homo sapiens	Q8IWZ3-1	Anti Tag CoIP	12812986
种属内	DISC1	Q9NRI5	MAP4K4	Homo sapiens	O95819	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	RGPD5	Homo sapiens	Q99666	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	RGPD5	Homo sapiens	Q99666	Y2H Fragment Pooling	31413325
种属间	DISC1	Q9NRI5	Mad2l1	Mus musculus	Q9Z1B5	Pull Down	29961565
种属间	DISC1	Q9NRI5	Cep170	Mus musculus	Q6A065	Pull Down	29961565
种属内	DISC1	Q9NRI5	DRD2	Homo sapiens	P14416	Anti Tag CoIP	32493513
种属内	DISC1	Q9NRI5	NUP160	Homo sapiens	Q12769	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NAV1	Homo sapiens	Q8NEY1	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NAV1	Homo sapiens	Q8NEY1	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	SPTBN4	Homo sapiens	Q9H254	Y2H	12812986
种属内	DISC1	Q9NRI5	ALMS1	Homo sapiens	Q8TCU4	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	ALMS1	Homo sapiens	Q8TCU4	Anti Tag CoIP	33961781
种属间	DISC1	Q9NRI5	Nde1	Mus musculus	Q9CZA6	Pull Down	29961565
种属内	DISC1	Q9NRI5	DST	Homo sapiens	Q03001	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	DST	Homo sapiens	Q03001	Y2H	17043677
种属内	DISC1	Q9NRI5	YWHAZ	Homo sapiens	P63104	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	SPTAN1	Homo sapiens	Q13813	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	SPTAN1	Homo sapiens	Q13813	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	GSN	Homo sapiens	P06396	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	SPTBN1	Homo sapiens	Q01082	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	SPTBN1	Homo sapiens	Q01082	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	MATR3	Homo sapiens	P43243	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	MATR3	Homo sapiens	P43243	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	DYNC1H1	Homo sapiens	Q14204	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	YWHAE	Homo sapiens	P62258	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	DNAJC7	Homo sapiens	Q99615	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	XRN2	Homo sapiens	Q9H0D6	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	XRN2	Homo sapiens	Q9H0D6	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NUP210	Homo sapiens	Q8TEM1	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	SPAG5	Homo sapiens	Q96R06	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	SPAG5	Homo sapiens	Q96R06	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	TNKS2	Homo sapiens	Q9H2K2	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	IMMT	Homo sapiens	Q16891	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	ATF4	Homo sapiens	P18848	Y2H	12812986
种属内	DISC1	Q9NRI5	ATF4	Homo sapiens	P18848	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	ATF5	Homo sapiens	Q9Y2D1	IF	12812986
种属内	DISC1	Q9NRI5	ATF5	Homo sapiens	Q9Y2D1	Y2H	12812986
种属内	DISC1	Q9NRI5	ATF5	Homo sapiens	Q9Y2D1	Anti Tag CoIP	12812986
种属内	DISC1	Q9NRI5	MACF1	Homo sapiens	Q9UPN3	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Y2H	12812986
种属内	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	IF	12812986
种属内	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	Y2H	12812986
种属内	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	IF	12812986
种属内	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NDEL1	Homo sapiens	Q9GZM8	Anti Tag CoIP	12812986
种属内	DISC1	Q9NRI5	TRAF3IP1	Homo sapiens	Q8TDR0	Anti Tag CoIP	12812986
种属内	DISC1	Q9NRI5	PCNT	Homo sapiens	O95613	Anti Tag CoIP	15094396
种属内	DISC1	Q9NRI5	PCNT	Homo sapiens	O95613	Cosedimentation	12812986
种属内	DISC1	Q9NRI5	PCNT	Homo sapiens	O95613	Y2H	15094396
种属内	DISC1	Q9NRI5	ITSN1	Homo sapiens	Q15811	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	RANBP9	Homo sapiens	Q96S59	Y2H	12812986
种属内	DISC1	Q9NRI5	RANBP9	Homo sapiens	Q96S59	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	RANBP9	Homo sapiens	Q96S59	Anti Tag CoIP	12812986
种属间	DISC1	Q9NRI5	Ndel1	Mus musculus	Q9ERR1	Pull Down	29961565
种属内	DISC1	Q9NRI5	EIF3H	Homo sapiens	O15372	Y2H	12812986
种属内	DISC1	Q9NRI5	EIF3H	Homo sapiens	O15372	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	EIF3H	Homo sapiens	O15372	Anti Tag CoIP	12812986
种属内	DISC1	Q9NRI5	GRIPAP1	Homo sapiens	Q4V328	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	GRIPAP1	Homo sapiens	Q4V328	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	GRIPAP1	Homo sapiens	Q4V328	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	TRIO	Homo sapiens	O75962	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	TRIM27	Homo sapiens	P14373	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	TRIM27	Homo sapiens	P14373	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	PAFAH1B1	Homo sapiens	P43034	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	PAFAH1B1	Homo sapiens	P43034	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	TRIM37	Homo sapiens	O94972	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	TRIM37	Homo sapiens	O94972	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	CEP63	Homo sapiens	Q96MT8	Y2H	12812986
种属内	DISC1	Q9NRI5	CEP63	Homo sapiens	Q96MT8	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	RNF40	Homo sapiens	O75150	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	RNF40	Homo sapiens	O75150	Anti Tag CoIP	33961781
种属间	DISC1	Q9NRI5	Gripap1	Mus musculus	Q8VD04	Pull Down	29961565
种属内	DISC1	Q9NRI5	ACTN2	Homo sapiens	P35609	Y2H	12812986
种属内	DISC1	Q9NRI5	ACTN2	Homo sapiens	P35609	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	GATAD2B	Homo sapiens	Q8WXI9	Anti Tag CoIP	29961565
种属内	DISC1	Q9NRI5	GATAD2B	Homo sapiens	Q8WXI9	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	ATF7IP	Homo sapiens	Q6VMQ6	Y2H	12812986
种属内	DISC1	Q9NRI5	CCDC141	Homo sapiens	Q6ZP82	Y2H	12812986
种属内	DISC1	Q9NRI5	SYNE1	Homo sapiens	Q8NF91	Y2H	12812986
种属内	DISC1	Q9NRI5	SYNE1	Homo sapiens	Q8NF91	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	MAP1A	Homo sapiens	P78559	Anti Tag CoIP	12812986
种属内	DISC1	Q9NRI5	MAP1A	Homo sapiens	P78559	Y2H	12812986
种属内	DISC1	Q9NRI5	NDE1	Homo sapiens	Q9NXR1	Anti Tag CoIP	33961781
种属内	DISC1	Q9NRI5	NDE1	Homo sapiens	Q9NXR1	Y2H Fragment Pooling	31413325
种属内	DISC1	Q9NRI5	NDE1	Homo sapiens	Q9NXR1	Anti Tag CoIP	29961565

种属间: 跨种属相互作用 种属内: 同种属相互作用

DISC1 抗体

目录号	产品名	应用	反应物种
HY-P82685	DISC1 Antibody (YA2430)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Schizophrenia 9

SCZD9	Schizophrenia 9 With Or Without An Affective Disorder
Schizophrenia Susceptibility Locus, Chromosome 1q42-Related	Schizophrenia 9, Susceptibility To
Schizophrenia Susceptibility Locus Chromosome 1q-Related	Schizophrenia, Type 9

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Schizophrenia 1

SCZD1	Schizophrenia Susceptibility Locus, Chromosome 5-Related
Schizophrenia 1 With Or Without An Affective Disorder

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Microcephaly-Polymicrogyria-Corpus Callosum Agenesis Syndrome

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Lissencephaly 1

LIS1	Classic Lissencephaly
Ils	Subcortical Laminar Heterotopia
Lissencephaly Due To Lis1 Mutation	Lissencephaly Sequence, Isolated
Lissencephaly, Classic	Pafah1b1-Related Lissencephaly
Classical Lissencephaly	Lissencephaly Type 1
Lissencephaly-1	Subcortical Band Heterotopia
Double Cortex	Lissencephaly Classic
Lissencephaly Sequence Isolated	Isolated Lissencephaly Sequence
Type 1 Lissencephaly	Lissencephaly Syndrome Type 1
SBH	Sclh
Lissencephaly, Type 1	Type I Lissencephaly

Cyclothymic Disorder

Cyclothymia	Cycloid Personality
Cyclothymic Personality	Affective Personality Disorder
Cyclothymic Personality Disorder	Cycloid Personality Disorder

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Tardive Dyskinesia

Drug-Induced Tardive Dyskinesia	Lingual-Facial-Buccal Dyskinesia
Neuroleptic-Induced Tardive Dyskinesia

Schizophrenia 5

SCZD5	Schizophrenia Susceptibility Locus, Chromosome 6q-Related
Schizophrenia 5 With Or Without An Affective Disorder

Subacute Delirium

Delirium

Acute Confusional State Nos

Paranoid Schizophrenia

Chronic Paranoid Schizophrenia	Paranoid Type Schizophrenia
Paranoid Type Schizophrenia Subchronic State	Paraphrenia - Late
Paraphrenic Schizophrenia	Schizophrenia, Paranoid

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Schizophrenia 2

SCZD2	Schizophrenia Susceptibility Locus, Chromosome 11q-Related
Schizophrenia Susceptibility Locus Chromosome 11q-Related

Schizotypal Personality Disorder

Schizotypal Personality

Schizophrenia 18

SCZD18	Schizophrenia 18 With Or Without An Affective Disorder
Schizophrenia Susceptibility 18	Chromosome 7q36.3 Duplication Syndrome, 362-Kb
Schizophrenia, Type 18

Paranoid Personality Disorder

Schizoid Personality Disorder

Bardet-Biedl Syndrome 4

BBS4	Bardet-Biedl Syndrome, Type 4

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Mental Depression

Depression

Depressive Disorder

Cannabis Abuse

Marijuana Abuse

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Spinocerebellar Ataxia 44

SCA44

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Delusional Disorder

Persistent Delusional Disorders	Delusional Perception
Induced Delusional Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Specific Developmental Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108909	Chymopapain		/	否
HY-121003	Aspyrone		/	否
HY-RS03781	DISC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DISC1	VGNC	VGNC:106712
Felis catus	DISC1	VGNC	VGNC:82471
Canis familiaris	DISC1	VGNC	VGNC:39965
Macaca mulatta	DISC1	VGNC	VGNC:71799
Mus musculus	DISC1	MGD	MGI:2447658
Rattus norvegicus	DISC1	RGD	RGD:631359

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