TNKS2 - tankyrase 2 Gene

中文名称：端锚聚合酶 2

种属: Homo sapiens

同用名: TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c

基因 ID: 80351 | 基因类型: protein coding

关于 TNKS2

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,798,426-91,865,475 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues.

功能概要

启用 NAD+ ADP-核糖基转移酶活性；酶结合活性；和蛋白质 ADP-核糖基酶活性。参与多个过程，包括蛋白质 ADP-核糖基化；蛋白质定位于染色体、端粒区域；和端粒维护的调节。位于核膜中；周围物质；和细胞质的核周区。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD+ ADP-ribosyltransferase activity; Enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 基因产物(6)

mRNA	Protein	Name
XM_011540213.2	XP_011538515.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X1
XM_047425795.1	XP_047281751.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X5
XM_017016701.2	XP_016872190.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X4
NM_025235.4	NP_079511.1	poly [ADP-ribose] polymerase tankyrase-2
XM_017016699.2	XP_016872188.1	poly [ADP-ribose] polymerase tankyrase-2 isoform X2
XM_017016700.3	XP_016872189.2	poly [ADP-ribose] polymerase tankyrase-2 isoform X3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	11739745	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: 通过直接分析推断	19759537	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	21251231	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11854288	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of telomere maintenance via telomere lengthening	IMP IMP: 通过突变表型推断	25939383	GOA
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	19759537	GOA
involved in positive regulation of telomere capping	IMP IMP: 通过突变表型推断	25939383	GOA
involved in protein auto-ADP-ribosylation	IDA IDA: 通过直接分析推断	21478859	GOA
involved in protein localization to chromosome, telomeric region	IMP IMP: 通过突变表型推断	11739745	GOA
involved in protein poly-ADP-ribosylation	IDA IDA: 通过直接分析推断	25043379	GOA
involved in protein polyubiquitination	IDA IDA: 通过直接分析推断	19759537	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	11278563	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	11454873	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11739745	GOA
located in pericentriolar material	IDA IDA: 通过直接分析推断	11454873	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	11454873	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNKS2 蛋白结构

Ank_2

Ank

Ank_2

Ank

Ank_2

Ank_4

Ank_2

SAM_2

PARP

0
200
400
600
800
1000
1166 a.a.

蛋白主名

其他名称

poly [ADP-ribose] polymerase tankyrase-2

ADP-ribosyltransferase diphtheria toxin-like 6	TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2	poly [ADP-ribose] polymerase 5B
protein poly-ADP-ribosyltransferase tankyrase-2	tankyrase II
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	tankyrase-like protein
tankyrase-related protein

关联疾病

疾病名称

别名

Cherubism

CRBM	Familial Benign Giant-Cell Tumor Of The Jaw
Familial Fibrous Dysplasia Of Jaw	Familial Multilocular Cystic Disease Of The Jaws

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-12418	Stenoparib	Inhibitor	≥98.0%	Phase 2

Pre-clinical Phase

生物活性分子 (32)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15147	XAV-939	Inhibitor	99.91%	否
HY-12438	G007-LK	Inhibitor	99.24%	否
HY-13990	NVP-TNKS656		99.66%	否
HY-16910	WIKI4	Inhibitor	99.93%	否
HY-12975	AZ6102	Inhibitor	99.65%	否
HY-13968	JW 55	Inhibitor	98.95%	否
HY-19351	MN-64	Inhibitor	99.61%	否
HY-U00422	K-756	Inhibitor	99.25%	否
HY-145267	OM-153	Inhibitor	99.59%	否
HY-148063	DB0614		98.80%	否
HY-123851	MSC2504877	Inhibitor	98.50%	否
HY-15811	XMD8-87	Inhibitor	98.15%	否
HY-101243	XMD16-5	Inhibitor	98.59%	否
HY-148061	DB1113		99.28%	否
HY-143338	ART-IN-1	Inhibitor	98.91%	否
HY-121719	TIQ-A	Inhibitor	99.65%	否
HY-126248	Tankyrase-IN-2	Inhibitor	99.06%	否
HY-147886	PARP1-IN-11	Inhibitor	98.58%	否
HY-148065	FMF-06-098-1		/	否
HY-100847	AZ0108	Inhibitor	/	否
HY-12601	TNKS 22	Inhibitor	/	否
HY-145111	TNK2-IN-1	Inhibitor	/	否
HY-145266	OM-1700	Inhibitor	/	否
HY-146336	PARP1/2/TNKS1/2-IN-1		/	否
HY-153259	TNKS1/2-IN-2	Inhibitor	/	否
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	否
HY-23338	TNKS-2-IN-1	Inhibitor	95.77%	否
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-153332	Tankyrase-IN-5	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TNKS2	VGNC	VGNC:66423
Bos taurus	TNKS2	VGNC	VGNC:36186
Mus musculus	TNKS2	MGD	MGI:1921743
Rattus norvegicus	TNKS2	RGD	RGD:1305026
Canis familiaris	TNKS2	VGNC	VGNC:47683
Macaca mulatta	TNKS2	VGNC	VGNC:78983

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