2. Gene
  3. TNKS1BP1 - tankyrase 1 binding protein 1 Gene

TNKS1BP1 - tankyrase 1 binding protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：端锚聚合酶 1 结合蛋白 1

种属: Homo sapiens

同用名: TAB182

基因 ID: 85456 | 基因类型: protein coding

关于 TNKS1BP1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,299,642-57,324,952 (from NCBI)

This gene has 7 transcripts (splice variants), 112 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 32.4), fat (RPKM 31.8) and 24 other tissues.

功能概要

启用锚蛋白重复结合活性和酶结合活性。参与细胞对电离辐射的反应；双链断裂修复；和蛋白质磷酸化的正调节。位于几种细胞成分中，包括肌动蛋白细胞骨架；粘附连接；和异染色质。 CCR4-NOT 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ankyrin repeat binding activity and Enzyme binding activity. Involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Located in several cellular components, including actin cytoskeleton; adherens junction; and heterochromatin. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

TNKS1BP1 基因产物(1)

mRNA Protein Name
NM_033396.3 NP_203754.2 182 kDa tankyrase-1-binding protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ankyrin repeat binding IMP
IMP: 通过突变表型推断
11854288 GOA
enables ankyrin repeat binding IPI
IPI: 通过物理相互作用推断
11854288 GOA
enables enzyme binding IDA
IDA: 通过直接分析推断
11854288 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11854288 GOA
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
25749521 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to ionizing radiation IMP
IMP: 通过突变表型推断
25749521 GOA
involved in double-strand break repair IMP
IMP: 通过突变表型推断
25749521 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: 通过突变表型推断
25749521 GOA
involved in positive regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
25749521 GOA
involved in positive regulation of protein autophosphorylation IMP
IMP: 通过突变表型推断
25749521 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CCR4-NOT complex IDA
IDA: 通过直接分析推断
19558367 GOA
located in adherens junction IDA
IDA: 通过直接分析推断
11854288 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
11854288 GOA
located in heterochromatin IDA
IDA: 通过直接分析推断
11854288 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11854288 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNKS1BP1 蛋白结构

Tankyrase_bdg_C

Tankyrase_bdg_C: Tankyrase binding protein C terminal domain (1554 - 1726)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1729 a.a.
蛋白主名 其他名称

182 kDa tankyrase-1-binding protein

tankyrase 1 binding protein 1, 182kDa

关联疾病

疾病名称 别名
Cherubism

CRBM

Familial Benign Giant-Cell Tumor Of The Jaw

Familial Fibrous Dysplasia Of Jaw

Familial Multilocular Cystic Disease Of The Jaws
Alcohol-Induced Mental Disorder

Psychoses, Alcoholic
Substance-Induced Psychosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TNKS1BP1 MGD MGI:2446193
Rattus norvegicus TNKS1BP1 RGD RGD:1312021
Canis familiaris TNKS1BP1 VGNC VGNC:47682
Macaca mulatta TNKS1BP1 VGNC VGNC:79181
Felis catus TNKS1BP1 VGNC VGNC:66422
Bos taurus TNKS1BP1 VGNC VGNC:36185
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