TOB1 - transducer of ERBB2, 1 Gene

中文名称：ERBB2, 1 换能器

种属: Homo sapiens

同用名: TOB; TROB; APRO5; APRO6; PIG49; TROB1

基因 ID: 10140 | 基因类型: protein coding

关于 TOB1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,862,223-50,867,978 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 113.0), thyroid (RPKM 46.6) and 25 other tissues.

功能概要

该基因编码 erbB-2/B 细胞易位基因蛋白家族的一个成员。该家族的成员是具有调节细胞生长潜力的抗增殖因子。所编码的蛋白质可能起到肿瘤抑制因子的作用。交替剪接导致多个转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

TOB1 基因产物(3)

mRNA	Protein	Name
NM_001243877.2	NP_001230806.1	protein Tob1 isoform 1
NM_001243885.2	NP_001230814.1	protein Tob1 isoform 2
NM_005749.4	NP_005740.1	protein Tob1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18377426	GOA
enables receptor tyrosine kinase binding	IDA IDA: 通过直接分析推断	8632892	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	8632892	GOA
involved in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	18377426	GOA
involved in negative regulation of translation	IDA IDA: 通过直接分析推断	23236473	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: 通过直接分析推断	21336257	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: 通过直接分析推断	21336257	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CCR4-NOT complex	IDA IDA: 通过直接分析推断	21336257	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOB1 蛋白结构

BTG

0
100
200
300
345 a.a.

蛋白主名

其他名称

protein Tob1

proliferation-inducing gene 49

TOB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	TOB1	P50616	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	18377426
Intra	TOB1	P50616	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	28514442
Intra	TOB1	P50616	CNOT10	Homo sapiens	Q9H9A5	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	18377426
Intra	TOB1	P50616	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	33961781
Intra	TOB1	P50616	TNKS1BP1	Homo sapiens	Q9C0C2	Anti Tag CoIP	28514442
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	GMS	19276069
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	Pull Down	19276069
Intra	TOB1	P50616	CNOT7	Homo sapiens	Q9UIV1	Y2H Array	31515488
Intra	TOB1	P50616	RAVER1	Homo sapiens	Q8IY67	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CPEB4	Homo sapiens	Q17RY0	Anti Tag CoIP	21336257
Intra	TOB1	P50616	CPEB4	Homo sapiens	Q17RY0	Pull Down	21336257
Intra	TOB1	P50616	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	TOB1	P50616	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	TOB1	P50616	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	TOB1	P50616	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	TOB1	P50616	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	TOB1	P50616	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	TOB1	P50616	CNOT9	Homo sapiens	Q92600	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT9	Homo sapiens	Q92600	Anti Tag CoIP	28514442
Intra	TOB1	P50616	CNOT9	Homo sapiens	Q92600	TAP	18377426
Intra	TOB1	P50616	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	TOB1	P50616	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	TOB1	P50616	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	TOB1	P50616	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	33961781
Intra	TOB1	P50616	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	28514442
Intra	TOB1	P50616	PABPC1	Homo sapiens	P11940	ITC	20595394
Intra	TOB1	P50616	PABPC1	Homo sapiens	P11940	NMR	20595394
Intra	TOB1	P50616	CPEB3	Homo sapiens	Q8NE35	Pull Down	21336257
Intra	TOB1	P50616	CPEB3	Homo sapiens	Q8NE35	Anti Tag CoIP	21336257

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14872	TOB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TOB1	VGNC	VGNC:78613
Mus musculus	TOB1	MGD	MGI:1349721
Felis catus	TOB1	VGNC	VGNC:82316
Bos taurus	TOB1	VGNC	VGNC:36212
Canis familiaris	TOB1	VGNC	VGNC:49663
Rattus norvegicus	TOB1	RGD	RGD:621126

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TOB1 - transducer of ERBB2, 1 Gene

关于 TOB1

功能概要

TOB1 基因产物(3)

TOB1 蛋白结构

TOB1 蛋白互作信息

关联疾病

直系同源

热门区域

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TOB1 - transducer of ERBB2, 1 Gene

关于 TOB1

功能概要

TOB1 基因产物(3)

TOB1 蛋白结构

TOB1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z