2. Gene
  3. CNOT6L - CCR4-NOT transcription complex subunit 6 like Gene

CNOT6L - CCR4-NOT transcription complex subunit 6 like Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CCR4-NOT 转录复合亚基 6 样

种属: Homo sapiens

同用名: CCR4b

基因 ID: 246175 | 基因类型: protein coding

关于 CNOT6L

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:77,713,387-77,820,269 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues.

功能概要

预计会启用 poly (A) 特异性核糖核酸酶活性。参与细胞群增殖的正调控和细胞质 mRNA 加工体装配的正调控。位于细胞质和细胞核中。 CCR4-NOT 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT6L 基因产物(13)

mRNA Protein Name
NM_001286790.2 NP_001273719.1 CCR4-NOT transcription complex subunit 6-like isoform 1
NM_001365006.1 NP_001351935.1 CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001365007.2 NP_001351936.1 CCR4-NOT transcription complex subunit 6-like isoform 2
NM_001387835.1 NP_001374764.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387836.1 NP_001374765.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387837.1 NP_001374766.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387838.1 NP_001374767.1 CCR4-NOT transcription complex subunit 6-like isoform 3
NM_001387839.1 NP_001374768.1 CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387840.1 NP_001374769.1 CCR4-NOT transcription complex subunit 6-like isoform 4
NM_001387841.1 NP_001374770.1 CCR4-NOT transcription complex subunit 6-like isoform 5
NM_001387842.1 NP_001374771.1 CCR4-NOT transcription complex subunit 6-like isoform 6
NM_001387843.1 NP_001374772.1 CCR4-NOT transcription complex subunit 6-like isoform 6
NM_144571.3 NP_653172.2 CCR4-NOT transcription complex subunit 6-like isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17452450 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21233283 GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly IMP
IMP: 通过突变表型推断
21233283 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CCR4-NOT complex IDA
IDA: 通过直接分析推断
19558367 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21233283 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21233283 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNOT6L 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (56 - 114)

Exo_endo_phos

Exo_endo_phos: Endonuclease/Exonuclease/phosphatase family (192 - 529)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 555 a.a.
蛋白主名 其他名称

CCR4-NOT transcription complex subunit 6-like

carbon catabolite repressor protein 4 homolog B

CNOT6L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CNOT6L Q96LI5 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
33961781
Intra CNOT6L Q96LI5 CNOT1 Homo sapiens A5YKK6
Anti Bait CoIP
21984185
Intra CNOT6L Q96LI5 CNOT1 Homo sapiens A5YKK6
Anti Tag CoIP
22977175
Intra CNOT6L Q96LI5 TNKS1BP1 Homo sapiens Q9C0C2
Anti Tag CoIP
17452450
Intra CNOT6L Q96LI5 TNKS1BP1 Homo sapiens Q9C0C2
Anti Tag CoIP
33961781
Intra CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Anti Tag CoIP
33961781
Intra CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Validated Y2H
32296183
Intra CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Y2H Prey Pooling
32296183
Intra CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Anti Bait CoIP
21984185
Intra CNOT6L Q96LI5 CNOT7 Homo sapiens Q9UIV1
Y2H Array
32296183
Intra CNOT6L Q96LI5 CNOT9 Homo sapiens Q92600
Anti Tag CoIP
33961781
Intra CNOT6L Q96LI5 TOB1 Homo sapiens P50616
TAP
18377426
Intra CNOT6L Q96LI5 TOB1 Homo sapiens P50616
Anti Tag CoIP
18377426
Intra CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Validated Y2H
32296183
Intra CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Anti Tag CoIP
33961781
Intra CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Y2H Array
32296183
Intra CNOT6L Q96LI5 CNOT8 Homo sapiens Q9UFF9
Y2H Prey Pooling
32296183
Intra CNOT6L Q96LI5 CNOT2 Homo sapiens Q9NZN8
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02906 CNOT6L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CNOT6L VGNC VGNC:39417
Felis catus CNOT6L VGNC VGNC:61029
Bos taurus CNOT6L VGNC VGNC:27521
Rattus norvegicus CNOT6L RGD RGD:1309128
Mus musculus CNOT6L MGD MGI:2443154
Macaca mulatta CNOT6L VGNC VGNC:100211
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