CNOT2 - CCR4-NOT transcription complex subunit 2 Gene

中文名称：CCR4-NOT 转录复合物亚基 2

种属: Homo sapiens

同用名: NOT2; CDC36; NOT2H; HSPC131; IDNADFS

基因 ID: 4848 | 基因类型: protein coding

关于 CNOT2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:70,243,018-70,354,993 (from NCBI)

This gene has 42 transcripts (splice variants), 266 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues.

功能概要

该基因编码多组分 CCR4-NOT 复合物的一个亚基。 CCR4-NOT 复合物调节 mRNA 合成和降解，也被认为参与 mRNA 剪接、运输和定位。编码的蛋白质与组蛋白脱乙酰酶相互作用，并作为聚合酶 II 转录的阻遏物发挥作用。已观察到该基因的可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]

CNOT2 基因产物(3)

mRNA	Protein	Name
NM_001199302.2	NP_001186231.1	CCR4-NOT transcription complex subunit 2 isoform a
NM_001199303.2	NP_001186232.1	CCR4-NOT transcription complex subunit 2 isoform a
NM_014515.7	NP_055330.1	CCR4-NOT transcription complex subunit 2 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to poly(A)-specific ribonuclease activity	IMP IMP: 通过突变表型推断	21299754	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10637334	GOA
enables transcription corepressor binding	IDA IDA: 通过直接分析推断	16712523	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of intracellular estrogen receptor signaling pathway	IMP IMP: 通过突变表型推断	16778766	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	14707134	GOA
involved in positive regulation of cytoplasmic mRNA processing body assembly	IMP IMP: 通过突变表型推断	21299754	GOA
involved in regulation of stem cell population maintenance	IMP IMP: 通过突变表型推断	22367759	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CCR4-NOT complex	IDA IDA: 通过直接分析推断	19558367	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	21299754	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CNOT2 蛋白结构

NOT2_3_5

0
100
200
300
400
500
540 a.a.

蛋白主名

其他名称

CCR4-NOT transcription complex subunit 2

CC chemokine receptor 4-negative regulator of transcription 2

CNOT2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CNOT2	Q9NZN8	ZFHX3	Homo sapiens	Q15911-2	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	ZFHX3	Homo sapiens	Q15911-2	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	GCSAM	Homo sapiens	Q8N6F7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	GCSAM	Homo sapiens	Q8N6F7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT2	Q9NZN8	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	GPS1	Homo sapiens	Q13098-7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	GPS1	Homo sapiens	Q13098-7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CNOT1	Homo sapiens	A5YKK6	Y2H	10637334
Intra	CNOT2	Q9NZN8	CNOT1	Homo sapiens	A5YKK6	Anti Bait CoIP	16778766
Intra	CNOT2	Q9NZN8	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	GALNT10	Homo sapiens	F2Z2M7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	GALNT10	Homo sapiens	F2Z2M7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	MTFR1L	Homo sapiens	Q9H019	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	MTFR1L	Homo sapiens	Q9H019	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	TBX2	Homo sapiens	Q13207	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	TBX2	Homo sapiens	Q13207	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	PSMB4	Homo sapiens	P28070	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	PSMB4	Homo sapiens	P28070	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	ARMC5	Homo sapiens	Q96C12	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	ARMC5	Homo sapiens	Q96C12	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	21981923
Intra	CNOT2	Q9NZN8	BEX1	Homo sapiens	Q9HBH7	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	BEX1	Homo sapiens	Q9HBH7	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	CNOT2	Q9NZN8	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	CNOT2	Q9NZN8	TOB1	Homo sapiens	P50616	TAP	18377426
Intra	CNOT2	Q9NZN8	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Y2H Pooling	16189514
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Y2H Array	20211142
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Y2H Array	31515488
Intra	CNOT2	Q9NZN8	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	26496610
Intra	CNOT2	Q9NZN8	BCL6	Homo sapiens	P41182	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Intellectual Developmental Disorder With Nasal Speech, Dysmorphic Facies, And Variable Skeletal Anomalies

IDNADFS

12q15q21.1 Microdeletion Syndrome

Del(12)(Q15)(Q21.1)	Deletion 12q15q21.1
Monosomy 12q15q21.1

Currarino Syndrome

Currarino Triad	Partial Sacral Agenesis With Intact First Sacral Vertebra, Presacral Mass And Anorectal Malformation
CURRAS

Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease	SMA1
Spinal Muscular Atrophy 1	Sma I
Sma, Infantile Acute Form	Muscular Atrophy, Infantile
Spinal Muscular Atrophy-1	Hmn Proximal Type I
Infantile Muscular Atrophy	Proximal Spinal Muscular Atrophy Type 1
Sma Type 1	Sma Type I
Sma-I	Hereditary Motor Neuropathy Proximal Type I
Progressive Muscular Atrophy Of Infancy	Proximal Spinal Muscular Atrophy, Type 1
Werdnig Hoffmann Disease	Infantile Spinal Muscular Atrophy
Infantile-Onset Spinal Muscular Atrophy	Proximal Hereditary Motor Neuropathy Type I
Sma Infantile Acute Form	Spinal Muscular Atrophy Type I
Werdnig-Hoffman Disease	Atrophy, Muscular, Spinal, Type 1

Brachydactyly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02902	CNOT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CNOT2	VGNC	VGNC:71387
Felis catus	CNOT2	VGNC	VGNC:68517
Mus musculus	CNOT2	MGD	MGI:1919318
Canis familiaris	CNOT2	VGNC	VGNC:39413
Bos taurus	CNOT2	VGNC	VGNC:27517
Rattus norvegicus	CNOT2	RGD	RGD:1311672

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4